REALIZATION OF BROADBAND AND INDEPENDENT POLARIZATION METAMATERIAL PERFECT ABSORBER BASED ON THE THIRD-ORDER RESONANCE

In this report, we studied numerically and experimentally the electromagnetic properties of perfect MAs using ring-shaped structures at microwave frequencies. By creating a magnetic resonance, the ring structure confines electromagnetic energy at the first- and third-order resonances. And then, we leveraged the super-cell structures, which consist of different rings in one unit cell to obtain broadband absorption. The results showed that the absorption band of MA is broaden from 1.3 to 2.17 GHz when the number of rings in the unit cell increases from four to nine-ring

Effect of the feeding condition and number of dominant follicles on oestrus synchronization in Swamp buffalo

The research aimed to assess how feeding conditions and the number of the dominant follicles (DF) influence oestrus synchronization in swamp buffaloes. A total of 170 swamp female buffaloes raised in semi-grazing and housekeeping were included in the study. The synchronization used CIDR method and the follicles on the day of CIDR (Controlled Internal Drug Releasing) insert and removal were tracked by sonography. The results indicated that the age of first mating, age at first calving, and caving interval showed no significant differences in the two feeding conditions. The number of follicles at CIDR insertion and removal decreased in semi-grazing, but increased in housekeeping buffaloes. The percentage of buffalo without DF, one DF, and two DFs at CIDR withdrawal did not differ statistically. The percentage of estrus was 100% in both groups. Pregnancy rates were 53.18% in semi- grazing and 52.63% in housekeeping. The onset of oestrus was similar, but the duration of oestrus was longer in the buffaloes without DF than those with one or two DFs. The percentage of pregnant buffaloes in the group without DF was significantly lower than that in the other two groups. In summary, the efficiency of oestrus synchronization did not differ between semi-grazing and housekeeping methods. Buffaloes without DF displayed longer oestrus periods and lower pregnancy rates compared to those with one or two DFs in the ovarian system

STUDY ON INSPECTION OF THE PUTATIVE HYBRIDS BETWEEN TRACK-LACKING WILD MALE GAUR (BOS GAURUS) AND DOMESTIC FEMALE COW (BOS TAURUS) IN PHUOC BINH NATIONAL PARK, VIETNAM

Hybridization between wild and domestic bovine occurs widely due to the overlapping of the natural habitat of the wild and human farm animals. Due to the loss of habitat, the number of wild gaur (Bos gaurus) in Vietnam was in serious decline. Since 2009, a male wild gaur (Bos gaurus) has appeared and incorporated with female domestic cows (Bos taurus) in buffer zone Phuoc Binh National Park, on the border with Lam Dong and Ninh Thuan provinces. Then, several calves were born that carried some traits of wild gaur including physical characteristics and behaviors. These calves were supposed to be offspring between wild gaur and domestic cows. In previous study, the karyotypes of putative calves were identified with 2n = 58 and non-homologous chromosome 28 and 29 in these hybrids. In this study, we characterized the putative hybrids between track-lacking Bos gaurus and Bos taurus for breeding and preservation using Cytochrome b analysis, microsatellites and a novel marker growth hormone factor 1 (POU1F1). Cytochrome b analysis indicated the maternal lineage of the putative hybrids, with 100% nucleotide sequence identity. Microsatellite BM861 and sequence of ZFY gene region reveal Bos taurus chromosome Y origin was among the male putative hybrids. Importantly, the analysis of POU1F1 gene sequence on 1 chromosome showed efficacy in determining both Bos gaurus and Bos taurus lineage in the putative hybrids. The karyotyping results were confirmed by molecular analysis and our results provide a feasible way for detecting the putative hybrids between wild and domestic cattle in case of lacking the wild trace

Adoptive NK Cell Therapy - a Beacon of Hope in Multiple Myeloma Treatment

Major advances in the treatment of multiple myeloma (MM) have been achieved by effective new agents such as proteasome inhibitors, immunomodulatory drugs, or monoclonal antibodies. Despite significant progress, MM remains still incurable and, recently, cellular immunotherapy has emerged as a promising treatment for relapsed/refractory MM. The emergence of chimeric antigen receptor (CAR) technology has transformed immunotherapy by enhancing the antitumor functions of T cells and natural killer (NK) cells, leading to effective control of hematologic malignancies. Recent advancements in gene delivery to NK cells have paved the way for the clinical application of CAR-NK cell therapy. CAR-NK cell therapy strategies have demonstrated safety, tolerability, and substantial efficacy in treating B cell malignancies in various clinical settings. However, their effectiveness in eliminating MM remains to be established. This review explores multiple approaches to enhance NK cell cytotoxicity, persistence, expansion, and manufacturing processes, and highlights the challenges and opportunities associated with CAR-NK cell therapy against MM. By shedding light on these aspects, this review aims to provide valuable insights into the potential of CAR-NK cell therapy as a promising approach for improving the treatment outcomes of MM patients

SIP-MBA: A secure IoT platform with brokerless and micro-service architecture

The Internet of Things is one of the most interesting technology trends today. Devices in the IoT network are often geared towards mobility and compact in size, thus having a rather weak hardware configuration. There are many light weight protocols, tailor-made suitable for limited processing power and low energy consumption, of which MQTT is the typical one. The current MQTT protocol supports three types of quality-of-service (QoS) and the user has to trade-off the security of the packet transmission by transmission rate, bandwidth and energy consumption. The MQTT protocol, however, does not support packet storage mechanisms which means that when the receiver is interrupted, the packet cannot be retrieved. In this paper, we present a broker-less SIP-MBA Platform, designed for micro-service and using gRPC protocol to transmit and receive messages. This design optimizes the transmission rate, power consumption and transmission bandwidth, while still meeting reliability when communicating. Besides, we implement users and things management mechanisms with the aim of improving security issues. Finally, we present the test results by implementing a collect data service via gRPC protocol and comparing it with streaming data by using the MQTT protocol.Web of Science12759358

IoHT-MBA: An Internet of Healthcare Things (IoHT) platform based on microservice and brokerless architecture

Internet of Thing (IoT), currently, is one of the technology trends that are most interested. IoT can be divided into five main areas including: Health-care, Environmental, Smart city, Commercial and Industrial. The IoHT-MBA Platform is considered the backbone of every IoT architecture, so the optimal design of the IoHT-MBA Platform is essential issue, which should be carefully considered in the different aspects. Although, IoT is applied in multiple domains, however, there are still three main features that are challenge to improve: i) data collection, ii) users, devices management, and iii) remote device control. Today's medical IoT systems, often too focused on the big data or access control aspects of participants, but not focused on collecting data accurately, quickly, and efficiently; power redundancy and system expansion. This is very important for the medical sector - which always prioritizes the availability of data for therapeutic purposes over other aspects. In this paper, we introduce the IoHT Platform for Healthcare environment which is designed by microservice and brokerless architecture, focusing strongly on the three aforementioned characteristics. In addition, our IoHT Platform considers the five other issues including (1) the limited processing capacity of the devices, (2) energy saving for the device, (3) speed and accurate of the data collection, (4) security mechanisms and (5) scalability of the system. Also, in order for the IoHT Platform to be suitable for the field of health monitoring, we also add realtime alerts for the medical team. In the evaluation section, moreover, we describe the evaluation to prove the effectiveness of the proposed IoHT Platform (i.e. the proof-of-concept) in the performance, non-error, and non affected by geographical distance. Finally, a complete code solution is publicized on the authors' GitHub repository to engage further reproducibility and improvement.Web of Science12760159

Propofol and Aminophylline Antagonize Each Other During the Mobilization of Intracellular Calcium in Human Umbilical Vein Endothelial Cells

This study examined whether propofol and aminophylline affect the mobilization of intracellular calcium in human umbilical vein endothelial cells. Intracellular calcium was measured using laser scanning confocal microscopy. Cultured and serum-starved cells on round coverslips were incubated with propofol or aminophylline for 30 min, and then stimulated with lysophosphatidic acid, propofol and aminophylline. The results were expressed as relative fluorescence intensity and fold stimulation. Propofol decreased the concentration of intracellular calcium, whereas aminophylline caused increased mobilization of intracellular calcium in a concentration-dependent manner. Propofol suppressed the lysophosphatidic acid-induced mobilization of intracellular calcium in a concentration-dependent manner. Propofol further prevented the aminophylline-induced increase of intracellular calcium at clinically relevant concentrations. However, aminophylline reversed the inhibitory effect of propofol on the elevation of intracellular calcium by lysophosphatidic acid. Our results suggest that propofol and aminophylline antagonize each other on the mobilization of intracellular calcium in human umbilical vein endothelial cells at clinically relevant concentrations. Serious consideration should be given to how this interaction affects mobilization of intracellular calcium when these two drugs are used together

Two plant-associated Bacillus velezensis strains selected after genome analysis, metabolite profiling, and with proved biocontrol potential, were enhancing harvest yield of coffee and black pepper in large field trials

Elimination of chemically synthesized pesticides, such as fungicides and nematicides, in agricultural products is a key to successful practice of the Vietnamese agriculture. We describe here the route for developing successful biostimulants based on members of the Bacillus subtilis species complex. A number of endospore-forming Gram-positive bacterial strains with antagonistic action against plant pathogens were isolated from Vietnamese crop plants. Based on their draft genome sequence, thirty of them were assigned to the Bacillus subtilis species complex. Most of them were assigned to the species Bacillus velezensis. Whole genome sequencing of strains BT2.4 and BP1.2A corroborated their close relatedness to B. velezensis FZB42, the model strain for Gram-positive plant growth-promoting bacteria. Genome mining revealed that at least 15 natural product biosynthesis gene clusters (BGCs) are well conserved in all B. velezensis strains. In total, 36 different BGCs were identified in the genomes of the strains representing B. velezensis, B. subtilis, Bacillus tequilensis, and Bacillus. altitudinis. In vitro and in vivo assays demonstrated the potential of the B. velezensis strains to enhance plant growth and to suppress phytopathogenic fungi and nematodes. Due to their promising potential to stimulate plant growth and to support plant health, the B. velezensis strains TL7 and S1 were selected as starting material for the development of novel biostimulants, and biocontrol agents efficient in protecting the important Vietnamese crop plants black pepper and coffee against phytopathogens. The results of the large-scale field trials performed in the Central Highlands in Vietnam corroborated that TL7 and S1 are efficient in stimulating plant growth and protecting plant health in large-scale applications. It was shown that treatment with both bioformulations resulted in prevention of the pathogenic pressure exerted by nematodes, fungi, and oomycetes, and increased harvest yield in coffee, and pepper.Peer Reviewe