A numerically efficient implementation of the expectation maximization algorithm for state space models

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Assessing the strength of directed influences among neural signals : An approach to noisy data

Acknowledgements This work was supported by the German Science Foundation (Ti315/4-2), the German Federal Ministry of Education and Research (BMBF grant 01GQ0420), and the Excellence Initiative of the German Federal and State Governments. B.S. is indebted to the Kosterlitz Centre for the financial support of this research project.Peer reviewedPreprin

Improving network inference : The impact of false positive and false negative conclusions about the presence or absence of links

This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 642563.Peer reviewedPostprin

Detection of time-, frequency- and direction-resolved communication within brain networks

This work was in part supported by a grant from the Macdonald Trust to BP and BS, and by a grant from the Alzheimer Society (AS-PG-14-039) to BP and GR.Peer reviewedPublisher PD

Inferring directed climatic interactions with renormalized partial directed coherence and directed partial correlation

ACKNOWLEDGMENTS This work was supported in part by Spanish MINECO/FEDER (FIS2015-66503-C3-2-P) and ITN LINC (FP7 289447). C.M. also acknowledges partial support from ICREA ACADEMIAPeer reviewedPublisher PD

Granger causal time-dependent source connectivity in the somatosensory network

Peer reviewedPublisher PD

Quantitative assessment of cerebral connectivity deficiency and cognitive impairment in children with prenatal alcohol exposure

We would like to thank the patients, their parents, and technicians for their participation in this study. This research was supported by the National Natural Science Foundation (Grant No. 61601361), the Natural Science Foundation of Shaanxi Province in China (Grant No. 2017JM6013), the Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing (Contract No. SKL2017CP07), the Xi’an University of Technology, and the National Institutes of Health (NIH) grants (J. Stephen and T. Zhang—Grant Nos. P20AA017068, NCRR P20RR021938, NIGMS P20GM103472, and 1P50AA022534).Peer reviewedPostprintPostprintPublisher PD

Inferring directed climatic interactions with renormalized partial directed coherence and directed partial correlation

Copyright 2017 AIP Publishing. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP PublishingInferring interactions between processes promises deeper insight into mechanisms underlying network phenomena. Renormalised partial directed coherence is a frequency-domain representation of the concept of Granger causality, while directed partial correlation is an alternative approach for quantifying Granger causality in the time domain. Both methodologies have been successfully applied to neurophysiological signals for detecting directed relationships. This paper introduces their application to climatological time series. We first discuss the application to El Niño–Southern Oscillation—Monsoon interaction and then apply the methodologies to the more challenging air-sea interaction in the South Atlantic Convergence Zone (SACZ). In the first case, the results obtained are fully consistent with the present knowledge in climate modeling, while in the second case, the results are, as expected, less clear, and to fully elucidate the SACZ air-sea interaction, further investigations on the specificity and sensitivity of these methodologies are needed.Peer Reviewe

Cerebral Autoregulation and Neurovascular Coupling after Craniospinal Irradiation in Long-Term Survivors of Malignant Pediatric Brain Tumors of the Posterior Fossa.

INTRODUCTION  Long-term survivors of craniospinal irradiation have an increased risk for stroke which increases with radiation dose and follow-up time. Radiotherapy induces structural changes of the cerebral vasculature, affecting both, large, and small vessels. It is unknown how these structural changes affect functional mechanisms of cerebral blood flow regulation such as cerebral autoregulation and neurovascular coupling. METHODS  Using the transcranial Doppler, we compared dynamic cerebral autoregulation and neurovascular coupling of 12 patients after long-term survival of craniospinal irradiation due to a malignant pediatric brain tumor of the posterior fossa and 12 age- and sex-matched healthy patients. Mean arterial blood pressure and cerebral blood flow velocities in the middle and posterior cerebral artery were recorded at rest during normal breathing to assess cerebral autoregulation (transfer function parameters phase and gain, as well as the correlation coefficient indices Mx, Sx, and Dx), and during 10 cycles of a visual task to assess neurovascular coupling (parameters time delay, natural frequency, gain, attenuation, and rate time). RESULTS  Parameters of cerebral autoregulation showed a consistent trend toward reduced cerebral autoregulation in patients that did not reach statistical significance. Neurovascular coupling was not altered after craniospinal irradiation. CONCLUSION  In this pilot study, we demonstrated a trend toward reduced cerebral autoregulation, and no alteration of neurovascular coupling after irradiation in long-term survivors of malignant pediatric brain tumors of the posterior fossa