Technical Comparison of Three Surgical Methods: Open, Semi-closure, and Primary Closure in the Treatment of Pilonidal Sinus

Background and Objective: Pilonidal sinus of the sacrum is a relatively common chronic infectious disease. Surgical management of pilonidal sinus is a challenging matter, and despite the different surgical techniques, the recurrence rate is still high. Materials and Methods: This double-blind clinical trial study was conducted on 60 patients with pilonidal sinus (2023). These patients underwent surgery randomly and based on the available sampling method in three methods: open, semi-closure, and primary closure. Recovery time and intraoperative bleeding were recorded. The McGill Pain Questionnaire was used to evaluate postoperative pain, and the Southampton scale was employed to assess infection and secretions. Results: The recovery time was longer in the open method than in the closure and semi-closure methods (P=0.001). However, this difference did not exist between the closure and semi-closure methods (P=0.402). There were two cases of recurrence in the closed method, while no recurrence was observed in the open and semi-closure methods. The patients undergoing the closure surgical method experienced less bleeding postoperatively (P=0.002). No significant relationship was found between surgical method and infection (P=0.189). There was no significant difference in the intensity of pain experienced by patients after the operation (P=0.789). Conclusion: For the treatment of pilonidal sinus, primary surgical closure is not recommended due to recurrences, despite the shorter recovery time and less bleeding. The semi-closure surgical method seems to be safer than the open and primary closure methods

Relationship between the consumption of chronic methamphetamine on testosterone, LH and FSH among men’s

Background: Methamphetamine is simply made from available chemicals such as pseudoephedrine, this drug was previously used to treat ADHD, and a major contribution to controlling sexual acts in men and women is through the secretion of the GNRH gonadotropin hormone from the hypothalamus. This hormone enters the anterior pituitary through the portal vessels and secretes the LH and FSH hormone. The purpose of this study was to investigate the relationship between chronic methamphetamine consumption on testosterone, LH and FSH in males. Materials and Methods: In this study, 30 men with chronic methamphetamine dose referred to health clinics in the city for the use of random sampling method and were assessed. The subjects completed the questionnaire of the Addiction Severity Index (ASI) and transferred to the laboratory after blood sampling. Results: The results showed that the duration of taking methamphetamine does not affect the amount of FSH. There was no significant difference observed between different times. However, the amount of methamphetamine consumption affects the level of LH and testosterone levels. Conclusion: Duration of taking methamphetamine has an effect on the level of LH and testosterone, but does not affect the FSH hormone. &nbsp

An optimal architecture of magneto-plasmonic core–shell nanoparticles for potential photothermal applications

International audienc

Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus-Maze

Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is one of the most widely used animal models of anxiety.  Methods: Male Wistar rats were randomly allocated to ten groups. Different groups of animals intraperitoneally received Win-55212 (0.3, 1 and 5 mg/kg) as CB1 receptor agonist, AM- 251 (0.3, 1 and 5 mg/kg) as CB1 receptor antagonist, URB-597 (0.03, 0.1 and 0.3 mg/kg) as endocannabinoid breakdown inhibitor or saline (as control group) 30 min before submitting into EPM test.  Results: The results showed that compared to the control group, Win-55212 (1 and 5 mg/kg) and URB-597 (0.1 and 0.3 mg/kg) significantly increased both of the time and percentage of entries into open arms. AM-251 (1 and 5 mg/kg) significantly decreased the time and percentage of entries into open arms in the EPM test. These substances have no effects on the total distance covered by animals and number of closed arm entries.  Discussion: It is concluded that activation of cannabinoid receptor exert anxiolytic effect while blocking of cannabinoid receptor resulted in anxiety behavior. The locomotor activity was not significantly changed by cannabinoid system. It is suggested that potentiation of cannabinoid system may be therapeutic strategy for the anxiety behavior

Antimalarial activity of Alcoholic Extract of Curcuma longa and Heracleum persicum on Cultivated Plasmodium falciparum 3D7 strain: Antimalarial Effect of C. longa and H. persicum

Introduction: Plasmodium falciparum causes the most fatal form of malaria in human. At present, the common treatments are not effective enough and the incidence of drug resistance is being increased in malarious areas. Therefore, presenting the novel methods for therapeutic purposes assumes significant importance.  Recent studies indicated that aqueous or alcoholic extracts of Curcuma longa and Heracleum persicum showed a broad spectrum of anti-microorganisms activity. In this in vitro study the effects of C. longa and H. persicum extracts were assessed on P. falciparum since there has been limited clinical research into their effectiveness on Malaria. Materials and Methods:  The alcoholic extracts of H. persicum and C. longa were prepared in 10-1, 10-3 and 10-5 mg/ml dilutions. These solutions were tested on P. falciparum with 10% parasitemia in RPMI 1640 medium with 10% hematocrit. Each of dilutions was examined in triplicate and the inhibitory effect of the solutions on parasites was measured via determining the average parasitemia and their schizont rate. Finally, the results were analyzed using SPSS software. Results: The rate of parasitemia declined in three different dilutions of both H. persicum and C. longa. The mean of antiplasmodial inhibitory activity of herbs was 83.23±2.47% in H.persicum and 99.91±0.0% in C.longa. Moreover, all dilutions of both H.persicum and C.longa showed significant effect on decreasing of schizont percentage in comparison with control group (P-value<0.05). Conclusions: the present study indicated that alcoholic extracts of C. longa and H. persicum possess acceptable antiplasmodial effects and could be developed as valuable alternatives to ineffective antimalarial drugs. These results support the claims of recent studies that C. longa and H. persicum, have considerable antimicrobial activities. Considering notable in vitro antiplasmodial efficacy of C.longa and H.persicum, further studies with in vivo method is recommended