Does Pethidine Hydrochloride Analgesia in Patients with Acute Appendicitis Alter the Diagnostic Accuracy of Clinical Evaluation: a Randomized Double-Blind Clinical Trial

Background: Prevalence of cancers associated with the use of oral tobacco (OT) is rising very rapidly and prevention of use is the best option to tackle this scenario. This cross-sectional study estimated the proportion of OT use and predictors associated with its initiation and determined the knowledge, attitude A total of 354 students (15-30 years age) in five colleges were interviewed by medical students and completed a peer reviewed, pre-tested, self-administered questionnaire. Chi square test and logistic regression analyses were applied to the results.Method: Thirty nine (11.0%) students were lifetime users of smokeless tobacco among which nineteen (5.4%) were occasional users, seven (2.0%) were current users and thirteen (3.6%) fulfilled the criterion for established users. Paan was the most commonly used form of smokeless tobacco followed by Nass. On univariate analysis, lifetime use of smokeless tobacco showed significant associations with the use of cigarettes, student gender (M > F), individual condition (native > guest) and kind of the College (Engineering > Psychology).Results: Although pain scores significantly reduced in pethidine group and there was a significant difference between the pethidine and placebo groups (p<0.05). Pethidine administration did not alter the physical signs, delay time to surgery, or diagnostic accuracy.Conclusion: According to the result of the study, use of pethidine does not affect the accuracy and time of surgical diagnosis and can effectively reduce the pain among patients with acute abdominal pain due to appendicitis.Copyright©2012 Department of Forensic Medicine and Toxicology. All rights reserved

Synthesis and biological studies of new quinazolines with ether functions in position 2

International audienc

The prevalence of burnout and its relationship with capital types among university staff in Tehran, Iran: A cross-sectional study

Burnout; Social capital; Cultural capital; Economic capital © 2021 The Author(s) Background: Burnout is a job-related syndrome that is common among university staff, and it is caused by various factors. The purpose of this study was to investigate the prevalence of burnout and its relationship with capital types among university staff in Tehran, Iran. Methods: A cross-sectional descriptive-analytical design was used in which 420 staff were randomly sampled from the Iran University of Medical Sciences. For data collection, the researchers used the Burnout Inventory of Maslach and Jackson and Capital Types Questionnaire. The data were entered into SPSS software (Version 22) and analyzed by descriptive and inferential statistics and regressions. Results: The mean burnout of staff was 84.42, and 45.9 of them had high burnout. A significant relationship was found among capital types, work experience, gender, education, and burnout. Multiple linear regressions also showed that independent variables estimated about 32 of the variance of the dependent variable, social capital, gender, and work experience, contributed more to explaining and predicting burnout index. Conclusion: Regarding the relationship between burnout and capital types (economic, cultural, and social), it is necessary to increase capital by increasing cultural activities, staff's knowledge level, income levels, informal groups, and finally, strengthening interpersonal relationships among staff. © 2021 The Author(s

Strategies for Multiplexed Electrochemical Sensor Development

Detection of multiple biomarkers for disease diagnosis or treatment monitoring has received a lot of attention due to their potential impact on clinical decision making. Electrochemical biosensors have become one of the preferred detection approaches, due to the simplicity of the accompanying instrumentation. This chapter will explore how electrochemical sensors can be utilized for detection of multiple analytes by integration of sensors into microfluidic microsystems. Some key fabrication technologies for such devices will be presented utilizing polymer microfabrication, paper-based approaches, and the use of printed circuit boards. Next, the use of electrode arrays will be presented along with some commercial platforms, outlining plausible paths towards a successful electrochemical multiplexed sensor. Novel approaches based on microbeads and various labels will then be introduced along with various strategies and technologies utilized to achieve ultrasensitive multiplexed detection

Meperidine (pethidine) versus morphine in acute pain management of opioid-dependent patients

Hassan Solhi,1 Hossein Sanaei-Zadeh,2 Sadra Solhi,1 Mohammad Ali Azizi Nadian,1 Morteza Gharibi,3 Bahman Sadeghi Sedeh4 1Department of Internal Medicine, Arak University of Medical Sciences, Arak, 2Emergency Room, Division of Medical Toxicology, Hazrat Ali-Asghar (p) Hospital, Shiraz University of Medical Sciences, Shiraz, 3Department of Emergency Medicine, Arak University of Medical Sciences, 4Department of Social Medicine, Arak University of Medical Sciences, Arak, Iran Abstract: The present study aimed to evaluate the effectiveness of morphine and meperidine (pethidine) as pain relief in opioid-dependent patients with acute pain. A total of 122 opioid-dependent patients with acute pain were included in the study. Their pain severity was assessed, using visual analog scale (VAS) scores ranging from 0 to 10. The patients randomly received intravenous morphine (up to 0.15 mg/kg) or meperidine (up to 1.5 mg/kg) for pain control by patient control analgesia (PCA) pump. The clinical opioid withdrawal scale (COWS) was employed for the assessment of withdrawal symptoms. The pain relief and the emergence of withdrawal symptoms were measured at 15, 30, and 60 minutes after drug administration. The patients who received morphine reported a better pain control compared to those who received meperidine (mean ± standard deviation [SD] VAS scores 4.11±1.90 vs 5.85±2.08 at the end of the study; P<0.001). On the other hand, the patients who received meperidine indicated prominent withdrawal symptoms (mean ± SD COWS scores 4.80±2.18 vs. 1.98±0.82 at the end of the study; P<0.001). Our findings revealed that morphine can be recommended in acute pain management of opioid-dependent patients. In addition, emergency physicians should ask their patients about any drug dependence before selecting the appropriate drug for their acute pain management. Keywords: pain management, meperidine, morphine, opioid dependency, withdrawal symptom

Distant learning and primary school teacher burnout: Assessing the effect during coronavirus disease (COVID-19) in Jeddah, Saudi Arabia, 2021

BACKGROUND: Teaching is indeed a very stressful occupation. Owing to the novel coronavirus SARS-CoV-2, certain changes were made in education in Saudi Arabia. A switch to a 100% distant learning in some courses was implemented, thereby increasing the burden on teachers. The aim of this study was to assess the level of burnout and the impact of distant learning on burnout in primary school teachers during the pandemic. MATERIALS AND METHODS: This cross-sectional study recruited 295 primary school teachers in Jeddah City, Saudi Arabia. Data were collected using self-administered questionnaire having two parts: the first part included questions on sociodemographic charecteristics and the second part included questions related to distant learning and the Arabic version of the Maslach Burnout Inventory. Chi-square test was used to assess association between burnout and various factors. For comparison of mean scores by various factors, analysis of variance (ANOVA) was performed. RESULTS: A high level of burnout was perceived by 48.4% of the teachers in the dimension of emotional exhaustion, 26.4% in the depersonalization dimension, and 60% in the reduced personal accomplishment dimension. Teachers in the public school showed a higher burnout score than teachers in the private schools. The teachers in 40–50 age group had higher scores than the teachers with other age groups. There were no significant differences in terms of gender and years of experience. A higher proportion of teachers working in private schools had higher personal accomplishment than teachers working in Government schools (P = 0.01). Regarding personal accomplishment and depersonalization subscales, there were differences between the different types of schools. The teachers who believed “distance/E-learning was difficult” had lower personal accomplishment score. CONCLUSION: According to the study, primary teachers in Jeddah suffer from burnout. More programs should be implemented to deal with teacher burnout and more research focusing on these groups should be done

Effects of educational intervention based on PRECEDE model on self care behaviors and control in patients with type 2 diabetes in 2012

BACKGROUND: Diabetes is a chronic disease and its control requires essential change in patients' life style. The aim of this study was survey of effects of educational intervention based on PRECEDE Model on self care behaviors and control in patients with type 2 diabetes. METHODS: This was a quasi-experimental study carried out in 78 patients with type 2 diabetes who have referred to Minoodasht clinic of diabetes. The educational program has been designed according to the PRECEDE Model. Prior to perform the educational intervention, the patients filled a questionnaire which was designed according to the structure of PRECEDE Model for type 2 diabetes patients. The diabetes education program was performed on three target groups (patients, their families and Health care personnel). After four weeks, the effects of the educational program have been evaluated through the same questionnaire. The findings were analyzed by SPSS version 16 and p-value less than 0.05 was taken as statistically significant. RESULTS: The mean age of participants was 49 years, 87.2 were married and 19.2 was illiterate. The rate of income of 44.9 was low. 66 had a family history of diabetes and 64 had been afflicted with diabetes more than 5 years. The Chi-square test showed a significant relationship between formation of a file in diabetes clinic and on-time presence to receive services and participation in the educational classes with the marital status variable. The results also showed that there is a significant relationship between observing food diet and job. The mean scores of knowledge, attitude, practice, reinforcing factors and enabling factors has increased after educational intervention. The Chi-square test shows a significant difference before and after of education intervention in stages of the model. CONCLUSION: The obtained results based on PRECEDE Model would support the positive effect of the educational intervention and its major elements (predisposing, enabling and reinforcing factors) on diabetes self-care behaviors

A cross-sectional study for determinations of prevention behaviors of domestic accidents in mothers with children less than 5- year

Background: Accidents are the first cause of death in children under 5- year, especially in low- and middle-income countries. The aim of this study was to identify the determinants of prevention behavior of domestic accidents in mothers of children fewer than 5 years old based on protection motivation theory (PMT). Materials and Methods: In this cross-sectional descriptive-analytic study, 190 mothers were randomly selected. The data collection tool was researcher made questionnaire about prevention behaviors of home accidents in children less than five years based on the structures of protection motivation theory.then collected data entered in the software SPSS-22 and were analyzed using descriptive and analytical statistical tests. Results: Mean of perceived response efficacy was in good level and mean of other structures of PMT were in moderate level. There was a significant correlations between the scores of perceived vulnerability (r=.39, P < 0.05) and perceived severity, between scores of perceived response efficacy and self-efficacy (r=.47, P < 0.05). In mothers with higher education, score of perceived response efficacy was higher (P < 0.05). Mean of scores of perceived response efficacy and self- efficacy were higher in mothers who take care of their child themselves more than mothers who other people took care of their child (P < 0.05). Conclusion: Mean score of perceived response was in good level and also mean scores of others structures were in moderate level .It seems that PMT can be used as a conceptual frame work for designing educational programs aimed to improve of prevention behaviors of home accidents among mothers with children less than 5 year

Factors influencing fast-food consumption among adolescents in Tehran: A qualitative study

Background: The consumption of different types of fast food is increasingly growing in all parts of the world, both in developed and developing countries. Because of the changes and transitions in the lifestyle and dietary habits of people, an increasing number of people from different age groups, particularly adolescents and young adults, are inclined toward consuming fast food. Objectives: The objective of this study was to investigate the factors influencing fast-food consumption among adolescents in Tehran, Iran. Patients and Methods: The present qualitative study was conducted in 2012 - 2013 in Tehran, the capital of Iran. To achieve the objective of this study, 42 adolescents were enrolled in this study through a purposive sampling method, and the required data was collected via individual semi-structured in-depth interviews. Data collection and analysis were carried out simultaneously, and the collected data was analyzed via a thematic content analysis and using MAXQDA 10 software. Results: In this study after coding the transcribed interviews, the findings were categorized into three main themes as follows: personal views, social factors, and family factors. Each theme included several categories and subcategories, and the coded sentences and phrases were placed under each category and subcategory. Conclusions: The results of this study showed that the number of factors promoting fast-food consumption appeared to be more than the inhibiting factors and that the diverse factors at the individual and social level influenced fast-food consumption among adolescents. © 2016, Iranian Red Crescent Medical Journal

A cross-sectional study for determinations of prevention behaviors of domestic accidents in mothers with children less than 5- year

Background: Accidents are the first cause of death in children under 5- year, especially in low- and middle-income countries. The aim of this study was to identify the determinants of prevention behavior of domestic accidents in mothers of children fewer than 5 years old based on protection motivation theory (PMT). Materials and Methods: In this cross-sectional descriptive-analytic study, 190 mothers were randomly selected. The data collection tool was researcher made questionnaire about prevention behaviors of home accidents in children less than five years based on the structures of protection motivation theory.then collected data entered in the software SPSS-22 and were analyzed using descriptive and analytical statistical tests. Results: Mean of perceived response efficacy was in good level and mean of other structures of PMT were in moderate level. There was a significant correlations between the scores of perceived vulnerability (r=.39, P < 0.05) and perceived severity, between scores of perceived response efficacy and self-efficacy (r=.47, P < 0.05). In mothers with higher education, score of perceived response efficacy was higher (P < 0.05). Mean of scores of perceived response efficacy and self- efficacy were higher in mothers who take care of their child themselves more than mothers who other people took care of their child (P < 0.05). Conclusion: Mean score of perceived response was in good level and also mean scores of others structures were in moderate level .It seems that PMT can be used as a conceptual frame work for designing educational programs aimed to improve of prevention behaviors of home accidents among mothers with children less than 5 year