1,125 research outputs found

    Selective dissolved air flotation of fine mineral particles

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    Imperial Users onl

    Chromosomal control of non-gliadin proteins from the 70% ethanol extract of wheat endosperm

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    The non-gliadin fraction of the 70% ethanol extracts of compensated nulli-tetrasomics and ditelosomics of Triticum aestivum cv. Chinese Spring has been analyzed by combined electrofocusing and electrophoresis. Seventeen of the 21 protein map components of the euploid have been ascribed to eight chromosomes: 4A, 3BS, 6BS, 7BS, 3D, 4D, 5D and 7DS. The relationship of the different map components with other proteins previously associated with the same chromosomes is discusse

    Geometric View of Measurement Errors

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    The slope of the best fit line from minimizing the sum of the squared oblique errors is the root of a polynomial of degree four. This geometric view of measurement errors is used to give insight into the performance of various slope estimators for the measurement error model including an adjusted fourth moment estimator introduced by Gillard and Iles (2005) to remove the jump discontinuity in the estimator of Copas (1972). The polynomial of degree four is associated with a minimun deviation estimator. A simulation study compares these estimators showing improvement in bias and mean squared error

    Only closed testing procedures are admissible for controlling false discovery proportions

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    We consider the class of all multiple testing methods controlling tail probabilities of the false discovery proportion, either for one random set or simultaneously for many such sets. This class encompasses methods controlling familywise error rate, generalized familywise error rate, false discovery exceedance, joint error rate, simultaneous control of all false discovery proportions, and others, as well as gene set testing in genomics and cluster inference in neuroimaging. We show that all such methods are either equivalent to a closed testing procedure, or are uniformly improved by one. Moreover, we show that a closed testing method is admissible if and only if all its local tests are admissible. This implies that, when designing methods, it is sufficient to restrict attention to closed testing. We demonstrate the practical usefulness of this design principle by obtaining more informative inferences from the method of higher criticism, and by constructing a uniform improvement of a recently proposed method.Development and application of statistical models for medical scientific researc

    Globaltest confidence regions and their application to ridge regression

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    We construct confidence regions in high dimensions by inverting the globaltest statistics, and use them to choose the tuning parameter for penalized regression. The selected model corresponds to the point in the confidence region of the parameters that minimizes the penalty, making it the least complex model that still has acceptable fit according to the test that defines the confidence region. As the globaltest is particularly powerful in the presence of many weak predictors, it connects well to ridge regression, and we thus focus on ridge penalties in this paper. The confidence region method is quick to calculate, intuitive, and gives decent predictive potential. As a tuning parameter selection method it may even outperform classical methods such as cross-validation in terms of mean squared error of prediction, especially when the signal is weak. We illustrate the method for linear models in simulation study and for Cox models in real gene expression data of breast cancer samples.Development and application of statistical models for medical scientific researc

    Method of Collective Degrees of Freedom in Spin Coherent State Path Integral

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    We present a detailed field theoretic description of those collective degrees of freedom (CDF) which are relevant to study macroscopic quantum dynamics of a quasi-one-dimensional ferromagnetic domain wall. We apply spin coherent state path integral (SCSPI) in the proper discrete time formalism (a) to extract the relevant CDF's, namely, the center position and the chirality of the domain wall, which originate from the translation and the rotation invariances of the system in question, and (b) to derive effective action for the CDF's by elimination of environmental zero-modes with the help of the {\it Faddeev-Popov technique}. The resulting effective action turns out to be such that both the center position and the chirality can be formally described by boson coherent state path integral. However, this is only formal; there is a subtle departure from the latter.Comment: 10 pages, 1 figur

    Re-identification of a lamnid shark embryo

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    nant female lamnid shark was caught that the morphometric arguments in the Strait of Messina, Mediterra- used by Sanzo (1912) did not rule out nean Sea. She was reported to contain the shortfin mako (Isurus oxyrinchus 25–30 embryos, one of which was Rafinesque, 1810) but that the high saved and taken to the local Marine fecundity of 25–30 was more consis-Institute, where it was subsequently tent with C. carcharias than with I. examined by Sanzo (1912). The male oxyrinchus or a Lamna species. A lack embryo measured 36.1 cm total length of information on lamnid reproduction (TL), weighed 800 g, and had a greatly and the misidentification of a likely distended abdomen, as is typical of Galeorhinus galeus (Stevens2) with a embryos of oophagous lamnoid sharks litter of 30 as Lamna by Neill (1811), (Gilmore, 1993). The mother and the may have led Sanzo (1912) to consider remaining embryos were not saved. the porbeagle Lamna nasus (Bon-Because Sanzo was not able to exam- naterre, 1788) instead of the shortfin ine the adult female from which the mako as the most likely alternativ

    Modeling Dengue Outbreaks

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    We introduce a dengue model (SEIR) where the human individuals are treated on an individual basis (IBM) while the mosquito population, produced by an independent model, is treated by compartments (SEI). We study the spread of epidemics by the sole action of the mosquito. Exponential, deterministic and experimental distributions for the (human) exposed period are considered in two weather scenarios, one corresponding to temperate climate and the other to tropical climate. Virus circulation, final epidemic size and duration of outbreaks are considered showing that the results present little sensitivity to the statistics followed by the exposed period provided the median of the distributions are in coincidence. Only the time between an introduced (imported) case and the appearance of the first symptomatic secondary case is sensitive to this distribution. We finally show that the IBM model introduced is precisely a realization of a compartmental model, and that at least in this case, the choice between compartmental models or IBM is only a matter of convenience.Comment: 18 pages, 6 figures, submited to Mathematical Bioscience

    Spin tunnelling in mesoscopic systems

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    We study spin tunnelling in molecular magnets as an instance of a mesoscopic phenomenon, with special emphasis on the molecule Fe8. We show that the tunnel splitting between various pairs of Zeeman levels in this molecule oscillates as a function of applied magnetic field, vanishing completely at special points in the space of magnetic fields, known as diabolical points. This phenomena is explained in terms of two approaches, one based on spin-coherent-state path integrals, and the other on a generalization of the phase integral (or WKB) method to difference equations. Explicit formulas for the diabolical points are obtained for a model Hamiltonian.Comment: 13 pages, 5 figures, uses Pramana style files; conference proceedings articl
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