7 research outputs found
Diagnóstico participativo de necesidades de formación técnica, científica y tecnológica de los distritos de frailes, San Cristóbal y el Rosario del cantón de Desamparados, 2008.
Proyecto de Investigación. Instituto Tecnológico de Costa Rica. Escuela de Ciencias Sociales; Universidad de Costa Rica. Escuela de Estadística, 2008.Este documento sistematiza el proceso de una Investigación Acción Participativa (IAP), realizado con metodologías cualitativas y cuantitativas, sobre las necesidades de formación técnica, científica y tecnológica en los distritos de Frailes, San Cristóbal y El Rosario del Cantón de Desamparados y su relación con los principales factores condicionantes de su desarrollo e impacto sociocultural, económico y ambiental, 2008. Asimismo, con el propósito de coadyuvar en el desarrollo humano sostenible en el ámbito local, explica la participación sociocultural, considerando la construcción de redes de organización, poder, innovación productiva y ambiental; analiza el perfil académico y las demandas de conocimientos, habilidades y destrezas de formación técnica, científica y tecnológica; propone un sistema de información de la educación sobre la calidad, cobertura y equidad, pertinencia e impacto, ciencia, tecnología e innovación; finalmente, explica la participación productiva y laboral, considerando el perfil académico-laboral.This paper presents a Participative – Active - Research (PAR) process on
technical, scientific and technologic required knowledge in Frailes, San Cristobal
and El Rosario districts, Canton of Desamparados, done with qualitative and
quantitative methodology, and its relation with the principal conditionings factors of
their development and social, cultural, economic and environmental impact, 2008.
Likewise, with the aim of help in the human sustainable development en local
ambit, explains the social and cultural participation, considering the construction of
nets of organization, power, productive and environmental innovation; analyses the
academic profile and demanded knowledge, abilities and skills on technical,
scientific and technologic formation; proposes an information system of education
with indicators to measure quality, covering and equality, pertinence and impact,
science, technology and innovation; finally, explains productive and work
participation, considering the academic and work profile.Instituto Tecnológico de Costa Rica; Universidad de Costa Rica
Low miR-222 expression in human visceral adipose tissue is associated with insulin resistance and PTEN and p53 mRNA levels
Introduction: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53).
Material and methods: VAT was obtained from normal-weight (NW), overweight, and obese (OW/OB) subjects with and without IR. Stem-loop RT-qPCR was used to evaluate miRNA expression levels. miRTarBase 4.0, miRWalk, and DIANA-TarBase v8 were used for prediction of validated target gene of the miRNA analysed. A qPCR was used to evaluate PTEN, p53, leptin (LEP), and adiponectin (ADIPOQ) mRNA.
Results: miR-222 was lower in IR subjects, and miR-222 and miR-378 negatively correlated with HOMA-IR. PTEN and p53 are miR-222 direct targets according to databases. mRNA expression of PTEN and p53 was lower in OW/OB subjects with and without IR, compared to NW group and its levels positively associated with miR-222. Additionally, p53 and PTEN are positively associated with serum leptin levels. On the other hand, miR-193b and miR-378 negatively correlated with serum leptin but not with mRNA levels. Moreover, miR-Let-7d negatively correlated with serum adiponectin but not with adiponectin mRNA levels.
Conclusions: Lower miR-222 levels are associated with IR, and PTEN and p53 expression; the implication of these genes in adipose tissue homeostasis needs more research
5to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica
El V Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2019, realizado del 6 al 8 de febrero de 2019 y organizado por la Universidad Politécnica Salesiana, ofreció a la comunidad académica nacional e internacional una plataforma de comunicación unificada, dirigida a cubrir los problemas teóricos y prácticos de mayor impacto en la sociedad moderna desde la ingeniería.
En esta edición, dedicada a los 25 años de vida de la UPS, los ejes temáticos estuvieron relacionados con la aplicación de la ciencia, el desarrollo tecnológico y la innovación en cinco pilares fundamentales de nuestra sociedad: la industria, la movilidad, la sostenibilidad ambiental, la información y las telecomunicaciones.
El comité científico estuvo conformado formado por 48 investigadores procedentes de diez países: España, Reino Unido, Italia, Bélgica, México, Venezuela, Colombia, Brasil, Estados Unidos y Ecuador.
Fueron recibidas un centenar de contribuciones, de las cuales 39 fueron aprobadas en forma de ponencias y 15 en formato poster. Estas contribuciones fueron presentadas de forma oral ante toda la comunidad académica que se dio cita en el Congreso, quienes desde el aula magna, el auditorio y la sala de usos múltiples de la Universidad Politécnica Salesiana, cumplieron respetuosamente la responsabilidad de representar a toda la sociedad en la revisión, aceptación y validación del conocimiento nuevo que fue presentado en cada exposición por los investigadores.
Paralelo a las sesiones técnicas, el Congreso contó con espacios de presentación de posters científicos y cinco workshops en temáticas de vanguardia que cautivaron la atención de nuestros docentes y estudiantes. También en el marco del evento se impartieron un total de ocho conferencias magistrales en temas tan actuales como la gestión del conocimiento en la universidad-ecosistema, los retos y oportunidades de la industria 4.0, los avances de la investigación básica y aplicada en mecatrónica para el estudio de robots de nueva generación, la optimización en ingeniería con técnicas multi-objetivo, el desarrollo de las redes avanzadas en Latinoamérica y los mundos, la contaminación del aire debido al tránsito vehicular, el radón y los riesgos que representa este gas radiactivo para la salud humana, entre otros
Diagnóstico participativo de necesidades de formación técnica, científica y tecnológica de los distritos de frailes, San Cristóbal y el Rosario del cantón de Desamparados, 2008.
Proyecto de Investigación. Instituto Tecnológico de Costa Rica. Escuela de Ciencias Sociales; Universidad de Costa Rica. Escuela de Estadística, 2008.Este documento sistematiza el proceso de una Investigación Acción Participativa (IAP), realizado con metodologías cualitativas y cuantitativas, sobre las necesidades de formación técnica, científica y tecnológica en los distritos de Frailes, San Cristóbal y El Rosario del Cantón de Desamparados y su relación con los principales factores condicionantes de su desarrollo e impacto sociocultural, económico y ambiental, 2008. Asimismo, con el propósito de coadyuvar en el desarrollo humano sostenible en el ámbito local, explica la participación sociocultural, considerando la construcción de redes de organización, poder, innovación productiva y ambiental; analiza el perfil académico y las demandas de conocimientos, habilidades y destrezas de formación técnica, científica y tecnológica; propone un sistema de información de la educación sobre la calidad, cobertura y equidad, pertinencia e impacto, ciencia, tecnología e innovación; finalmente, explica la participación productiva y laboral, considerando el perfil académico-laboral.This paper presents a Participative – Active - Research (PAR) process on
technical, scientific and technologic required knowledge in Frailes, San Cristobal
and El Rosario districts, Canton of Desamparados, done with qualitative and
quantitative methodology, and its relation with the principal conditionings factors of
their development and social, cultural, economic and environmental impact, 2008.
Likewise, with the aim of help in the human sustainable development en local
ambit, explains the social and cultural participation, considering the construction of
nets of organization, power, productive and environmental innovation; analyses the
academic profile and demanded knowledge, abilities and skills on technical,
scientific and technologic formation; proposes an information system of education
with indicators to measure quality, covering and equality, pertinence and impact,
science, technology and innovation; finally, explains productive and work
participation, considering the academic and work profile.Instituto Tecnológico de Costa Rica; Universidad de Costa Rica
REVISTA SERENGUETI 1(2)
Se destaca, de manera general, que la revista Serengueti se compone como una herramienta capaz de incentivar la participación estudiantil, en el cual principalmente se tiene como fin evidenciar y reconocer los esfuerzos realizados por parte de los estudiantes activos de la carrera de Estadística mediante artículos que son calificados y recomendados por los profesores del curso respectivo. Se promueve la revista como modelo para desarrollar en un futuro propuestas de enseñanza que permitan brindar diferentes formas y técnicas de aprendizaje. El volumen 2 se toma como eje temático el análisis multivariado, cuya finalidad es mediante un conjunto de métodos estadísticos y matemáticos, describir e interpretar los datos que provienen de la observación de variables estadísticas y que han sido analizadas simultáneamente (Cuadras, 2007, p.9)2. A partir de ello, se proponen algunas técnicas multivariantes como lo son el análisis factorial, técnicas de agrupamiento y minería de datos para predicción. Además, se realiza un apartado de simulaciones en el que se asocia al análisis factorial por la cercanía de los temas propuestos, pero la técnica de análisis se elabora desde un enfoque distinto.UCR::Vicerrectoría de Docencia::Ciencias Sociales::Facultad de Ciencias Económicas::Escuela de Estadístic
Global attitudes in the management of acute appendicitis during COVID-19 pandemic: ACIE Appy Study
Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis.
Methods: The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons globally regarding the management of patients with acute appendicitis during the pandemic. Questions were divided into baseline information, hospital organization and screening, personal protective equipment, management and surgical approach, and patient presentation before versus during the pandemic.
Results: Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There was variation in screening indications and modality used, with chest X-ray plus molecular testing (PCR) being the commonest (19\ub78 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6\ub76 and 2\ub74 per cent respectively before, but 23\ub77 and 5\ub73 per cent, during the pandemic (both P < 0\ub7001). One-third changed their approach from laparoscopic to open surgery owing to the popular (but evidence-lacking) advice from expert groups during the initial phase of the pandemic. No agreement on how to filter surgical smoke plume during laparoscopy was identified. There was an overall reduction in the number of patients admitted with appendicitis and one-third felt that patients who did present had more severe appendicitis than they usually observe.
Conclusion: Conservative management of mild appendicitis has been possible during the pandemic. The fact that some surgeons switched to open appendicectomy may reflect the poor guidelines that emanated in the early phase of SARS-CoV-2
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Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study an international prospective cohort study
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care