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The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence

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The Genome Sequence of Taurine Cattle:A Window to Ruminant Biology and Evolution

Author: Abatepaulo A.R.
Abbey C.A.
Adelson D.L.
Aerts J.
Ahola V.
Alexander L.
Alioto T.
Almeida I.G.
Amadio A.F.
Anatriello E.
Antonarakis S.E.
Anzola J.M.
Astashyn A.
Bahadue S.M.
Baldwin C.L.
Barris W.
Baxter R.
Bell S.N.
Bennett A.K.
Bennett G.L.
Biase F.H.
Boldt C.R.
Bovine Genome Sequencing
Bradley D.G.
Brinkman F.S.
Brinkmeyer-Langford C.L.
Brown W.C.
Brownstein M.J.
Buhay C.
Caetano A.R.
Carroll J.A.
Carvalho W.A.
Casey T.
Cervelatti E.P.
Chacko E.
Chacko J.
Chandrabose M.M.
Chapin J.E.
Chapple C.E.
Chen H.C.
Chen L.
Cheng Y.
Cheng Z.
Childers C.P.
Chitko-McKown C.G.
Chiu R.
Choi J.
Chrast J.
Colley A.J.
Connelley T.
Cree A.
Curry S.
CÃ¢mara F.
Dalrymple B.
Dao M.D.
Davis C.
de Campos T.A.
De Donato M.
de Oliveira C.J.
Deobald H.
Devinoy E.
Dickens C.M.
Ding Y.
Dinh H.H.
Donohue K.E.
Donthu R.
Dovc P.
Dugan-Rocha S.
Durbin K.J.
Eberlein A.
Edgar R.C.
Egan A.
Eggen A.
Eichler E.E.
Elhaik E.
Ellis S.A.
Elnitski L.
Elsik C.G.
Ermolaeva O.
Eyras E.
Fitzsimmons C.J.
Fowler G.R.
Franzin A.M.
Fritz K.
Gabisi R.A.
Garcia G.R.
Garcia J.F.
Genini S.
Gerlach D.
German J.B.
Gibbs R.A.
Gilbert J.G.
Gill C.A.
Gladney C.J.
Glass E.J.
Goodell J.
Grant J.R.
Graur D.
Greaser M.L.
Green J.A.
Green R.D.
Guan L.
GuigÃ³ R.
Hadsell D.L.
Hagen D.E.
Hakimov H.A.
Halgren R.
Hamernik D.L.
Hamilton C.
Harhay G.P.
Harrow J.L.
Hart E.A.
Hastings N.
Havlak P.
Henrichsen C.N.
Herdandez J.
Hernandez M.
Herzig C.T.
Hiendleder S.G.
Hines S.
Hitchens M.E.
Hlavina W.
Hobbs M.
Holder M.
Holt R.A.
Hu Z.L.
Hume J.
Iivanainen A.
Ingham A.
Iso-Touru T.
Jamis C.
Jann O.
Jensen K.
Jhangiani S.N.
Jiang H.
Johnson A.J.
Jones S.J.
Joshi V.
Junier T.
Kapetis D.
Kappes S.M.
Kapustin Y.
Keele J.W.
Kent M.P.
Kerr T.
Khalil S.S.
Khatib H.
Kiryutin B.
Kitts P.
Kokocinski F.
Kolbehdari D.
Kovar C.L.
Kriventseva E.V.
Kumar C.G.
Kumar D.
Lahmers K.K.
Landrum M.
Larkin D.M.
Lau L.P.
Leach R.
Lee J.C.
Lee S.
Lemay D.G.
Lewin H.A.
Lewis L.R.
Li C.
Lien S.
Liu G.E.
Liu Y.
Liu Y.S.
Logan K.M.
Lopez J.
Lozado R.J.
Lutzow Y.S.
Lynn D.J.
Macneil M.D.
Maglott D.
Malinverni R.
Maqbool N.J.
Marques E.
Marra M.A.
Martin W.F.
Martins N.F.
Maruyama S.R.
Matukumalli L.K.
Mazza R.
McEwan J.C.
McKay S.D.
McLean K.L.
McWilliam S.
Medrano J.F.
Memili E.
Moen C.
Molenaar A.J.
Moore R.
Moore S.S.
Moreno B.T.
Morgan M.B.
MorÃ© D.D.
Muntean C.T.
Muzny D.M.
Nandakumar H.P.
Nazareth L.V.
Nguyen N.B.
Nicholas F.W.
Nogueira M.F.
Okwuonu G.O.
Olsaker I.
Pant S.D.
Panzitta F.
Pastor R.C.
Patel B.M.
Payne G.M.
Plass M.
Poli M.A.
Poslusny N.
Pruitt K.
Pu L.L.
Qin X.
Rachagani S.
Raison J.M.
Ranganathan S.
Ratnakumar A.
Razpet A.
Reecy J.
Reese J.T.
Ren Y.
Reymond A.
Riggs P.K.
Rijnkels M.
Rincon G.
Roberts A.
Rodriguez-Osorio N.
Rodriguez-Zas S.L.
Romero N.E.
Rosenwald A.
Ruiz S.J.
Sabo A.
Salih H.
Sando L.
Santibanez J.
Santos I.K.
Sapojnikov V.
Schein J.E.
Schmutz S.M.
Schnabel R.D.
Schook L.
Searle S.M.
Seo S.
Shen L.
Shen Y.
Sherman L.
Skow L.C.
Smith T.
Snelling W.M.
Sodergren E.
Solovyev V.
Song H.
Song J.
Sonstegard T.S.
Southey B.R.
Souvorov A.
Spurlock D.
Steffen D.
Stone R.T.
Stothard P.
Sugimoto Y.
Sweedler J.V.
Takasuga A.
Tammen I.
Taniguchi M.
Taylor J.F.
Tellam R.L.
Telugu B.P.
Ucla C.
Urbanski J.M.
Utsunomiya Y.T.
Van Tassell C.P.
Vattathil S.
Verschoor C.P.
Waardenberg A.J.
Walker A.
Wang Z.
Ward R.
Warren J.T.
Waterman R.C.
Weikard R.
Weinstock G.M.
Welsh T.H.
Wheeler D.A.
Wheeler T.T.
White S.N.
Whiteside M.D.
Wilczek-Boney K.
Williams J.L.
Williams R.L.
Wilming L.G.
Womack J.
Worley K.C.
Wright R.A.
Wunderlich K.R.
Wyss C.
Yang J.
Yang M.Q.
Zdobnov E.M.
Zhang J.
Zhao F.Q.
Zhu B.
Publication venue
Publication date: 01/01/2009
Field of study

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.Fil: Bovine Genome Sequencing and Analysis Consortium. Bovine Genome Sequencing And Analysis Consortium; Estados UnidosFil: Amadio, Ariel Fernando. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Genética; Argentin

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