Microwave radiometer-scatterometer measurements

There are no author-identified significant results in this report

Statistics of Ku-band microwave response of the United States with a satellite borne radiometer/scatterometer

The author has identified the following significant results. The Skylab S-193 radiometer/scatterometer collected thousands of measurements of scattering coefficient and brightness temperature over various parts of the United States during the summer of 1973 at angles of incidence between vertical and about 45 deg. These measurements have been combined to produce histograms of the response at each of several angles within this range, and to establish average scattering coefficient vs angle curves with 10% and 90% exceedance levels as well. The variation of the radiometric measurements is primarily in the region from 255 K to 285 K, with very few measurements giving higher values, but a significant, though small, number giving values down to and even below 200 K. The scattering coefficient varies, for the mean, from about 0 db at 1 deg off vertical to a low in the neighborhood of -10 db at 45 deg. The variability of the scattering coefficient measurements with this coarse resolution sensor is surprisingly small. The number of distinguishable levels is slightly more for the scatterometer than for the radiometer, but the amount of variation in brightness temperature caused by the physical temperature of the ground is enough so that the scatterometer can be used to distinguish significantly more meaningful levels than the radiometer

Design data collection with Skylab/EREP microwave instrument S-193

There are no author-identified significant results in this report

Soil moisture detection by Skylab's microwave sensors

The author has identified the following significant results. Terrain microwave backscatter and emission response to soil moisture variations were investigated using Skylab's 13.9 GHz RADSCAT (radiometer/scatterometer) system. Data acquired on June 5, 1973, over a test site in west-central Texas indicated a fair degree of correlation with composite rainfall. The scan made was cross-track contiguous (CTC) with a pitch of 29.4 deg and no roll effect. Vertical polarization was employed with both radiometer and scatterometer. The composite rainfall was computed according to the flood prediction technique using rainfall data supplied by weather reporting stations

Preliminary S-193 RADSCAT oceanographic data for Skylab 2

There are no author-identified significant results in this report

Design data collection with Skylab/EREP microwave instrument S-193

There are no author-identified significant results in this report

Stratified glucocorticoid monotherapy is safe and effective for most cases of giant cell arteritis

Funding: We are grateful to Versus Arthritis (grant 12159) for supporting our work.Peer reviewedPublisher PD

Decoding the 5' nucleotide bias of PIWI-interacting RNAs

PIWI-interacting RNAs (piRNAs) are at the center of a small RNA-based immune system that defends genomes against the deleterious action of mobile genetic elements (transposons). PiRNAs are highly variable in sequence with extensive targeting potential. Their diversity is restricted by their preference to start with a Uridine (U) at the 5' most position (1U-bias), a bias that remains poorly understood. Here we uncover that the 1U-bias of Piwi-piRNAs is established by consecutive discrimination against all nucleotides but U, first during piRNA biogenesis and then upon interaction with Piwi's specificity loop. Sequence preferences during piRNA processing also restrict U across the piRNA body with the potential to directly impact target recognition. Overall, the uncovered signatures could modulate specificity and efficacy of piRNA-mediated transposon restriction, and provide a substrate for purifying selection in the ongoing arms race between genomes and their mobile parasites

Logistic regression prediction model identify type 2 diabetes mellitus as a prognostic factor for human papillomavirus-16 associated head and neck squamous cell carcinoma

Background: HPV-16–positive HNSCC and HPV-16–negative HNSCC have different clinical factors, representing distinct forms of cancers. The study aimed to identify patient-specific factors for HPV-16-positive HNSCC based on baseline clinical data. Method: Factors associated with HPV-16-positive HNSCC were identified using the data from 210 patients diagnosed with HNSCC at University College of London Hospital between January 1, 2003, and April 30, 2015, inclusive. A series of models were developed using logistic regression methods, and the overall model fit was compared using Akaike Information Criterion. Survival analysis was carried with Cox proportional hazards model for survival-time outcomes. The survival time for individual patients was defined as the time from diagnosis of HNSCC to the date of death from any cause. For patients who did not die, they were censored at the end of study on April 30, 2015. Results: Of the 210 patients, 151 (72%) were found to have HPV-16-positive HNSCC. The logistic regression model showed that the prevalence of developing HPV-16-positive HNSCC was 3.79 times higher in patients with Type 2 Diabetes Mellitus (T2DM) (odd ratio [OR], 3.79; 95% CI, 1.70–8.44) than in those without T2DM, and 8.84 times higher in patients with history of primary HNSCC (OR, 8.84; 95% CI, 2.30–33.88) than in those without a history of primary HNSCC. HPV-16–positive HNSCC was also observed more in tonsils (OR, 4.02; 95% CL, 1.56–10.36) and less in non-alcohol drinker’s oral cavity (OR, 0.14; 95% CI, 0.03–0.56). Furthermore, individual patients were followed-up for 1 to 13 years (median of 1 year). Patients with HPV-positive HNSCC had a median survival of 5 years (95% CI, 2.6–7.3 years). Among HPV-16–positive HNSCC cohort, T2DM was a risk for poorer prognosis (hazard ratio, 2.57; 95% Cl, 1.09–6.07), and had lower median survival of 3 years (95% CI, 1.8–4.1 years), as compared to 6 years (95% CI, 2.8–9.1 years) in non-T2DM. Conclusions: Patient-specific factors for HPV-positive HNSCC are T2DM, history of primary HNSCC and tonsillar site. T2DM is associated with poorer prognosis. These findings suggest that it might be beneficial if routine HPV-16 screening is carried out in T2DM patients which can provide better therapeutic and management strategies

The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122

The P body protein LSm1 stimulates translation and replication of hepatitis C virus (HCV). As the liver-specific microRNA-122 (miR-122) is required for HCV replication and is associated with P bodies, we investigated whether regulation of HCV by LSm1 involves miR-122. Here, we demonstrate that LSm1 contributes to activation of HCV internal ribosome entry site (IRES)-driven translation by miR-122. This role for LSm1 is specialized for miR-122 translation activation, as LSm1 depletion does not affect the repressive function of miR-122 at 3′ untranslated region (UTR) sites, or miR-122–mediated cleavage at a perfectly complementary site. We find that LSm1 does not influence recruitment of the microRNA (miRNA)-induced silencing complex to the HCV 5′UTR, implying that it regulates miR-122 function subsequent to target binding. In contrast to the interplay between miR-122 and LSm1 in translation, we find that LSm1 is not required for miR-122 to stimulate HCV replication, suggesting that miR-122 regulation of HCV translation and replication have different requirements. For the first time, we have identified a protein factor that specifically contributes to activation of HCV IRES-driven translation by miR-122, but not to other activities of the miRNA. Our results enhance understanding of the mechanisms by which miR-122 and LSm1 regulate HCV