Experimental Limit on the Cosmic Diffuse Ultra-high Energy Neutrino Flux

We report results from 120 hours of livetime with the Goldstone Lunar Ultra-high energy neutrino Experiment (GLUE). The experiment searches for <10 ns microwave pulses from the lunar regolith, appearing in coincidence at two large radio telescopes separated by 22 km and linked by optical fiber. Such pulses would arise from subsurface electromagnetic cascades induced by interactions of >= 100 EeV neutrinos in the lunar regolith. No candidates are yet seen, and the implied limits constrain several current models for ultra-high energy neutrino fluxes.Comment: 4 pages, 4 figures, revtex4 style. New intro section, Fig. 2, Fig 4; in final PRL revie

Персонифицированная реабилитация пациентов после новой коронавирусной инфекции: опыт Республики Марий Эл

Two years after the onset of the COVID-19 pandemic, not only the diagnosis and treatment, but also rehabilitation of patients at different times after the disease became relevant.The aim. To develop and analyze the efficiency of personalized hospital-based rehabilitation programs for COVID-19 patients.Methods. Retrospective analysis of medical records of 109 patients with COVID-19 admitted to the rehabilitation department. A team of physiotherapist, pulmonologist and psychiatrist used simulators (bicycle ergometer, treadmill, motomed, and stepper), physiotherapeutic exercises, training of respiratory muscles with Threshold IMT (Philips, Netherlands) simulators, psychotherapy, and physiotherapy.Results. A total of 109 patients, 59 (54%) men and 50 (46%) women, aged 56.54 ± 11.73 уears suffered from moderate (41%), severe (40%) and very severe (19%) COVID-19. 25% of the patients had concomitant diabetes mellitus, 65% – arterial hypertension, and 22% – ischemic heart disease. Patients with 5 rehabilitation points (5RP) on Rehabilitation Routing Scale walked a median distance of 110 [40; 248] m in the 6-minute walk test (6MWT), 4RP – 300 [240; 350] m in 6MWT, 3RP — 400 [360; 431] m in 6MWT. The difference in 6MWT distance was significant only between 4RP and 3RP groups (p &lt; 0.001). By the end of rehabilitation program, 6MWT increased by 90 m in 5RP group, by 120 m – in 4RP group, and by 89 m in patients with 3RP (p = 0.036 between RPs and 4RP groups; р = 0.007 between 3RP and 5RP groups, respectively). SpO2 was over 95% in all patients by the end of rehabilitation.Conclusion. Comorbid patients after severe COVID-19 demonstrated better rehabilitation potential seen as improvement of exercise tolerance and respiratory status. The original personalized rehabilitation programs improve significantly impaired body functions early on after severe COVID-19.Спустя 2 года с начала пандемии COVID-19 (COronaVIrus Disease-2019) все более актуализируются не только задачи диагностики и лечения, но и вопросы реабилитации пациентов на разных сроках после перенесенного заболевания.Целью исследования явилась оценка эффективности оригинальных персонифицированных программ, нацеленных на восстановление пациентов c COVID-19 в условиях круглосуточного стационара.Материалы и методы. Проведен ретроспективный анализ медицинских карт 109 пациентов с COVID-19, госпитализированных в реабилитационное отделение. Реабилитация проводилась командой специалистов (врач физической и реабилитационной медицины, пульмонолог, психиатр), включала персонифицированные тренировки на тренажерах (велоэргометр, тредмил, мотомед, степпер), лечебную физкультуру, тренировки дыхательной мускулатуры с тренажерами Threshold IMT (Philips, Нидерланды), психотерапию, физиотерапию.Результаты. В исследовании участвовали 59 мужчин (54 %) и 50 (46 %) женщин; средний возраст – 56,54 ± 11,73 года. У 41 % обследованных течение COVID-19 было среднетяжелым, у 40 % – тяжелым, у 19 % – крайне тяжелым. В структуре коморбидности регистрировались сахарный диабет (25 %), гипертоническая болезнь (65 %), ишемическая болезнь сердца (22 %). При поступлении пациенты с оценкой 5 баллов (РБ5) по шкале реабилитационной маршрутизации проходили в среднем 110 [40; 248] м в 6-минутном шаговом тесте, больные с оценкой 4 балла (РБ4) – 300 [240; 350] м, 3 балла (РБ3) – 400 [360; 431] м. Различия результатов 6-минутного шагового теста (6-МШТ) в группах с РБ4 и РБ3 были достоверны (p &lt; 0,001). В динамике прирост расстояния в 6-МШТ составил 90 м при РБ5, 120 м – при РБ4, 89 м – при РБ3 (p = 0,036 при сравнении РБ3 и РБ4; р = 0,007 при сравнении РБ3 и РБ5). К завершению реабилитационных программ у всех пациентов нормализовались показатели сатурации кислорода.Заключение. У пациентов с тяжелым COVID-9 и сопутствующими заболеваниями выявлен хороший реабилитационный потенциал, выражавшийся в повышении толерантности к физической нагрузке и улучшении респираторного статуса. Это позволяет говорить о влиянии на возможности восстановления нарушенных функций организма после тяжелых форм COVID-19

RATAN-600 7.6-cm Deep Sky Strip Surveys at the Declination of the SS433 Source During the 1980-1999 Period. Data Reduction and the Catalog of Radio Sources in the Right-Ascension Interval 7h < R.A. < 17h

We use two independent methods to reduce the data of the surveys made with RATAN-600 radio telescope at 7.6 cm in 1988-1999 at the declination of the SS433 source. We also reprocess the data of the "Cold" survey (1980-1981). The resulting RCR (RATAN COLD REFINED) catalog contains the right ascensions and fluxes of objects identified with those of the NVSS catalog in the right-ascension interval 7h < R.A. < 17h. We obtain the spectra of the radio sources and determine their spectral indices at 3.94 and 0.5 GHz. The spectra are based on the data from all known catalogs available from the CATS, Vizier, and NED databases, and the flux estimates inferred from the maps of the VLSS and GB6 surveys. For 245 of the 550 objects of the RCR catalog the fluxes are known at two frequencies only: 3.94 GHz (RCR) and 1.4 GHz (NVSS). These are mostly sources with fluxes smaller than 30 mJy. About 65% of these sources have flat or inverse spectra (alpha > -0.5). We analyze the reliability of the results obtained for the entire list of objects and construct the histograms of the spectral indices and fluxes of the sources. Our main conclusion is that all 10-15 mJy objects found in the considered right-ascension interval were already included in the decimeter-wave catalogs.Comment: 26 pages, 18 figure

RC J0311+0507: A Candidate for Superpowerful Radio Galaxies in the Early Universe at Redshift z=4.514

A strong emission line at 6703A has been detected in the optical spectrum for the host galaxy (R=23.1) of the radio source RC J0311+0507 (4C+04.11). This radio galaxy, with a spectral index of 1.31 in the frequency range 365-4850 MHz, is one of the ultrasteep spectrum objects from the deep survey of a sky strip conducted with RATAN-600 in 1980-1981. We present arguments in favor of the identification of this line with Ly\alpha at redshift z=4.514. In this case, the object belongs to the group of extremely distant radio galaxies of ultrahigh radio luminosity (P_{1400}=1.3 x 10^{29}W Hz^{-1}). Such power can be provided only by a fairly massive black hole (~10^9M_\sun}) that formed in a time less than the age of the Universe at the observed z(1.3 Gyr) or had a primordial origin.Comment: 8 pages, 3 figure

Assessment of adherence to treatment in patients

The article presents an analysis of adherence to treatment of patients with essential hypertension at the Central City Hospital No. 3, Yekaterinburg. Our questionnaire survey explored 27 patients of both sexes at the age of 52 (47; 58) years with stages 1-2 of hypertension. The results of the questionnaire showed low adherence level to antihypertensive therapy. Male patients appeared to be less adherent to treatment than femaleВ статье приведен анализ приверженности к лечению пациентов с гипертонической болезнью, обратившихся за амбулаторной помощью в ЦГБ №3 г. Екатеринбурга. В исследование вошли 27 пациентов обоих полов в возрасте 52 (47; 58) года с 1-2 стадией гипертонической болезни. По результатам анкетирования среди участников исследования отмечался низкий уровень комплаентности к антигипертензивной терапии. При анализе по половому признаку мужчины демонстрировали более низкие значения показателя приверженности в сравнении с лицами женского пол

NCBI GEO: archive for high-throughput functional genomic data

The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) is the largest public repository for high-throughput gene expression data. Additionally, GEO hosts other categories of high-throughput functional genomic data, including those that examine genome copy number variations, chromatin structure, methylation status and transcription factor binding. These data are generated by the research community using high-throughput technologies like microarrays and, more recently, next-generation sequencing. The database has a flexible infrastructure that can capture fully annotated raw and processed data, enabling compliance with major community-derived scientific reporting standards such as ‘Minimum Information About a Microarray Experiment’ (MIAME). In addition to serving as a centralized data storage hub, GEO offers many tools and features that allow users to effectively explore, analyze and download expression data from both gene-centric and experiment-centric perspectives. This article summarizes the GEO repository structure, content and operating procedures, as well as recently introduced data mining features. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/

NCBI GEO: archive for functional genomics data sets—10 years on

A decade ago, the Gene Expression Omnibus (GEO) database was established at the National Center for Biotechnology Information (NCBI). The original objective of GEO was to serve as a public repository for high-throughput gene expression data generated mostly by microarray technology. However, the research community quickly applied microarrays to non-gene-expression studies, including examination of genome copy number variation and genome-wide profiling of DNA-binding proteins. Because the GEO database was designed with a flexible structure, it was possible to quickly adapt the repository to store these data types. More recently, as the microarray community switches to next-generation sequencing technologies, GEO has again adapted to host these data sets. Today, GEO stores over 20 000 microarray- and sequence-based functional genomics studies, and continues to handle the majority of direct high-throughput data submissions from the research community. Multiple mechanisms are provided to help users effectively search, browse, download and visualize the data at the level of individual genes or entire studies. This paper describes recent database enhancements, including new search and data representation tools, as well as a brief review of how the community uses GEO data. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/

Catalog of Radio Galaxies with z>0.3. I:Construction of the Sample

The procedure of the construction of a sample of distant ($z>0.3$) radio galaxies using NED, SDSS, and CATS databases for further application in statistical tests is described. The sample is assumed to be cleaned from objects with quasar properties. Primary statistical analysis of the list is performed and the regression dependence of the spectral index on redshift is found.Comment: 9 pages, 6 figures, 2 table

Analysis of the RC catalog sample in the region overlapping with the regions of the FIRST and SDSS surveys: I. Identification of sources with the VLSS, TXS, NVSS, FIRST, and GB6 catalogs

Radio sources of the RC catalog produced in 1980--1985 at RATAN-600 radio telescope based on a deep survey of a sky strip centered on the declination of the SS 433 source are optically identified in the region overlapping with FIRST and SDSS surveys (about 132 square degrees). The NVSS catalog was used as the reference catalog for refining the coordinates of the radio sources. The morphology is found for about 75% of the objects of the sample and the ratio of single, double and multicomponent radio sources is computed based on FIRST radio maps. The 74, 365, 1400, and 4850 MHz data of the VLSS, TXS, NVSS, FIRST, and GB6 catalogs are used to analyze the shape of the spectra.Comment: 16 pages, 3 figure