Modelling Opinion Formation with Physics Tools: Call for Closer Link with Reality

The growing field of studies of opinion formation using physical formalisms and computer simulation based tools suffers from relative lack of connection to the 'real world' societal behaviour. Such sociophysics research should aim at explaining observations or at proposing new ones. Unfortunately, this is not always the case, as many works concentrate more on the models themselves than on the social phenomena. Moreover, the simplifications proposed in simulations often sacrifice realism on the altar of computability. There are several ways to improve the value of the research, the most important by promoting truly multidisciplinary cooperation between physicists aiming to describe social phenomena and sociologists studying the phenomena in the field. In the specific case of modelling of opinion formation there are a few technical ideas which might bring the computer models much closer to reality, and therefore to improve the predictive value of the sociophysics approach.Methodology, Agent Based Social Simulation, Qualitative Analysis; Evidence; Conditions of Application

Dilbert-Peter Model of Organization Effectiveness: Computer Simulations

We describe a computer model of general effectiveness of a hierarchical organization depending on two main aspects: effects of promotion to managerial levels and efforts to self-promote of individual employees, reducing their actual productivity. The combination of judgment by appearance in the promotion to higher levels of hierarchy and the Peter Principle (which states that people are promoted to their level of incompetence) results in fast declines in effectiveness of the organization. The model uses a few synthetic parameters aimed at reproduction of realistic conditions in typical multilayer organizations. It is shown that improving organization resiliency to self-promotion and continuity of individual productiveness after a promotion can greatly improve the overall organization effectiveness.Organization Productivity, Peter Principle, Agent Based Modeling

Negative emotions boost users activity at BBC Forum

We present an empirical study of user activity in online BBC discussion forums, measured by the number of posts written by individual debaters and the average sentiment of these posts. Nearly 2.5 million posts from over 18 thousand users were investigated. Scale free distributions were observed for activity in individual discussion threads as well as for overall activity. The number of unique users in a thread normalized by the thread length decays with thread length, suggesting that thread life is sustained by mutual discussions rather than by independent comments. Automatic sentiment analysis shows that most posts contain negative emotions and the most active users in individual threads express predominantly negative sentiments. It follows that the average emotion of longer threads is more negative and that threads can be sustained by negative comments. An agent based computer simulation model has been used to reproduce several essential characteristics of the analyzed system. The model stresses the role of discussions between users, especially emotionally laden quarrels between supporters of opposite opinions, and represents many observed statistics of the forum.Comment: 29 pages, 6 figure

Magnetotransport Properties and Subband Structure of the Two-Dimensional Electron Gas in the Inversion Layer of Hg1-xCdxTe Bicrystals

The electronic and magnetotransport properties of conduction electrons in the grain boundary interface of p-type Hg1-xCdxTe bicrystals are investigated. The results clearly demonstrate the existence of a two-dimensional degenerate n-type inversion layer in the vicinity of the grain boundary. The observed quantum oscillations of the magnetoresistivity result from a superposition of the Shubnikov-de Haas effect in several occupied electric subbands. The occupation of higher subbands is presumable depending on the total carrier density ns of the inversion layer. Electron densities, subband energies, and effective masses of these electric subbands in samples with different total densities are determined. The effective masses of lower subbands are markedly different from the band edge values of the bulk material, their values decrease with decreasing electron density and converging to the bulk values at lower densities. This agrees with predictions of the triangular potential well model and a pronounced nonparabolicity of the energy bands in Hg1-xCdxTe. At high magnetic fields (B > 10 T) it is experimentally verified that the Hall resistivity xy is quantized into integer multiplies of h/e2

Potential implication of Paxillin in cancer establishment within the bone environment

Background: Bone metastases are a common feature of advanced prostatic malignancies. They are characterised by a unique prevalence of osteoblastic phenotype and a poor prognosis. Paxillin is a 68-kDa signal transduction adaptor and scaffold protein that contains motifs involved in the mediation of protein–protein interactions. The state of paxillin phosphorylation is central to determining a cell's ability to adhere, detach and migrate and hence has been linked to processes such as wound repair and tumour metastasis. The current study explored the impact of paxillin suppression on prostate and breast cancer cell function and their responsiveness to hepatocyte growth factor (HGF) and bone matrix extract (BME) in order to assess its potential to influence bone colonization and homing. Materials and Methods: Hammerhead ribozyme transgenes were used to knockdown the expression of paxillin in breast and prostate cancer cell lines. The impact on the cell growth, migration, adhesion and invasion was assessed using in vitro functional assays. In order to explore potential mechanisms, focal adhesion kinase (FAK) inhibitor was also used. Results: Knockdown of paxillin expression was observed in all tested cell lines following transfection with the ribozyme transgene. The knockdown of paxillin increased proliferation and invasiveness of LNCaP cells, with no effect on their attachment abilities. The opposite, however, is true for PC-3 cells where, following knockdown, cellular attachment was significantly reduced, while no significant changes in growth and invasiveness were detected. In the MDA-MB-231 breast cancer knockdown model, cells had little difference in proliferative rates and generally increased attachment and reduced invasive abilities. Treatments with HGF and BME had differential effects on targeted cells when compared to controls. Conclusion: These data suggest that paxillin appears to influence major cell functions in a diverse range of prostate and breast cancer models. The responsiveness of cells to environmental factors such as HGF or BME may be influenced by paxillin status, although this seems to be dependent on cell type