205 research outputs found
One bridge, two Williams: Photographic integrity in the age of ubiquity
A brief and personal exploration of integrity in photography in relation to identity. Starting with an analysis of the differing photographic practices of William Klein and William Eggleston, as a means of entering the discourse of what integrity means for the professional photographer working across genres
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Accessing The Bioavailability Of Phytochemicals In Caco-2 Cell Model And Developing A Sensitive Method For The Detection And Quantification Of These Compounds
Numerous studies have found certain unmethylated phytochemicals to possess anti-carcinogenic activity; however, they have been associated with poor oral bioavailability which is a major limiting factor in their usage in chemopreventative treatment. The purpose of this study was to investigate if methylation of a compound would affect bioavailability, in terms of transport and permeability, in a Caco-2 cell model as well as the effect of cell viability and cellular uptake in human colon cancer cell lines. Furthermore, a new analytic method using reversed-phase high performance liquid chromatography coupled with electrochemical detector (HPLC-EC) for the detection and quantification of resveratrol and pterostilbene was developed.
This new method was simple, rapid, and more sensitive compared to other detection methods used to analyze resveratrol and pterostilbene. Linear range, limit of detection (LOD), precision and recovery were used to validate this new analytical method. There was a significant increase in intracellular uptake and stronger growth inhibitory of pterostilbene in human cancer cells lines in comparison to resveratrol. Resveratrol exhibited a higher and more rapid rate of transport than pterostilbene across the Caco-2 monolayer regardless of the concentration tested and direction. Pterostiblene exhibited little difference in the rate of transport from either direction. The HCT-116 colon cells had intracellular uptake of each of the polymethoxyflavones (PMFs) tested. Transport was observed by all the PMFs and each had different rates of transport. Overall, location and amount of methyl groups had an effect on bioavailablity of a compound and these compounds show promise as chemopreventative agents
The acrolect in Jamaica: The architecture of phonological variation
An ability to speak Jamaican Standard English is the stated requirement for any managerial or frontline position in corporate Jamaica. This research looks at the phonological variation that occurs in the formal speech of this type of employee, and focuses on the specific cohort chosen to represent Jamaica in interactions with local and international clients. The variation that does emerge, shows both the presence of some features traditionally characterized as Creole and a clear avoidance of other features found in basilectal and mesolectal Jamaican. Some phonological items are prerequisites for “good English” - variables that define the user as someone who speaks English - even if other Creole variants are present. The ideologies of language and language use that Jamaican speakers hold about “good English” clearly reflect the centuries-old coexistence of English and Creole, and suggest local norms must be our starting point for discussing the acrolect
The acrolect in Jamaica: The architecture of phonological variation
An ability to speak Jamaican Standard English is the stated requirement for any managerial or frontline position in corporate Jamaica. This research looks at the phonological variation that occurs in the formal speech of this type of employee, and focuses on the specific cohort chosen to represent Jamaica in interactions with local and international clients. The variation that does emerge, shows both the presence of some features traditionally characterized as Creole and a clear avoidance of other features found in basilectal and mesolectal Jamaican. Some phonological items are prerequisites for “good English” - variables that define the user as someone who speaks English - even if other Creole variants are present. The ideologies of language and language use that Jamaican speakers hold about “good English” clearly reflect the centuries-old coexistence of English and Creole, and suggest local norms must be our starting point for discussing the acrolect
The acrolect in Jamaica: The architecture of phonological variation
An ability to speak Jamaican Standard English is the stated requirement for any managerial or frontline position in corporate Jamaica. This research looks at the phonological variation that occurs in the formal speech of this type of employee, and focuses on the specific cohort chosen to represent Jamaica in interactions with local and international clients. The variation that does emerge, shows both the presence of some features traditionally characterized as Creole and a clear avoidance of other features found in basilectal and mesolectal Jamaican. Some phonological items are prerequisites for “good English” - variables that define the user as someone who speaks English - even if other Creole variants are present. The ideologies of language and language use that Jamaican speakers hold about “good English” clearly reflect the centuries-old coexistence of English and Creole, and suggest local norms must be our starting point for discussing the acrolect
The acrolect in Jamaica: The architecture of phonological variation
An ability to speak Jamaican Standard English is the stated requirement for any managerial or frontline position in corporate Jamaica. This research looks at the phonological variation that occurs in the formal speech of this type of employee, and focuses on the specific cohort chosen to represent Jamaica in interactions with local and international clients. The variation that does emerge, shows both the presence of some features traditionally characterized as Creole and a clear avoidance of other features found in basilectal and mesolectal Jamaican. Some phonological items are prerequisites for “good English” - variables that define the user as someone who speaks English - even if other Creole variants are present. The ideologies of language and language use that Jamaican speakers hold about “good English” clearly reflect the centuries-old coexistence of English and Creole, and suggest local norms must be our starting point for discussing the acrolect
The acrolect in Jamaica: The architecture of phonological variation
An ability to speak Jamaican Standard English is the stated requirement for any managerial or frontline position in corporate Jamaica. This research looks at the phonological variation that occurs in the formal speech of this type of employee, and focuses on the specific cohort chosen to represent Jamaica in interactions with local and international clients. The variation that does emerge, shows both the presence of some features traditionally characterized as Creole and a clear avoidance of other features found in basilectal and mesolectal Jamaican. Some phonological items are prerequisites for “good English” - variables that define the user as someone who speaks English - even if other Creole variants are present. The ideologies of language and language use that Jamaican speakers hold about “good English” clearly reflect the centuries-old coexistence of English and Creole, and suggest local norms must be our starting point for discussing the acrolect
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