A finite element model using a unified formulation for the analysis of viscoelastic sandwich laminates

In this paper we present a layerwise finite element model for the analysis of sandwich laminated plates with a viscoelastic core and laminated anisotropic face layers. The stiffness and mass matrices of the element are obtained by Carrera's Unified Formulation (CUF). The dynamic problem is solved in the frequency domain with viscoelastic frequency-dependent material properties for the core. The dynamic behaviour of the model is compared with solutions found in the literature, including experimental data

The use of visible and near infrared reflectance spectroscopy to predict beef M. longissimus thoracis et lumborum quality attributes

Visible and near infrared reflectance spectroscopy was used to predict pH at 24 h (pH24) post-mortem, sarcomere length (SL), cooking loss (CL), Warner–Bratzler Shear Force (WBSF) and colour parameters (L*, a*, b*) in beef cattle samples. Samples from M. longissimus thoracis et lumborum from 30 bulls were aged at 4 C for 1, 3, 7 and 14 days and analysed for pH, SL, CL, WBSF and colour. NIRS calibrations for pH24, luminosity at 0 (L*t0) and 60 min (L*t60) showed good predictability (R2 = 0.97, 0.85 and 0.82; SECV = 0.10, 1.16, 1.36, respectively), whereas those related to the rest of the parameters were poore

Identificação de parâmetros elásticos e piezoelétricos em estruturas activas tipo placa : técnicas de optimização clássica versus redes neuronais artificiais

Neste trabalho são apresentados dois métodos não destrutivos para a identificação de parâmetros elásticos e piezoeléctricos em estruturas laminadas activas do tipo placa, com sensores/actuadores de superfície. O primeiro destes métodos resolve o problema inverso através de métodos de optimização clássica, minimizando a diferença entre frequências naturais experimentais e as fornecidas por um modelo de elementos finitos. O segundo método baseia-se na construção de um “meta-modelo” do problema inverso, recorrendo a Redes Neuronais Artificiais. Os dois métodos são comparados recorrendo a resultados experimentais de uma placa em vibração livre

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1:a novel anticancer small-molecule

Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of wild-type (wt) and mut p53, using a yeast-based screening strategy. SLMP53-1 has a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells. Additionally, SLMP53-1 enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K. In wt/mut p53-expressing tumor cells, SLMP53-1 triggers p53 transcription-dependent and mitochondrial apoptotic pathways involving BAX, and wt/mut p53 mitochondrial translocation. SLMP53-1 inhibits the migration of wt/mut p53-expressing tumor cells, and it shows promising p53-dependent synergistic effects with conventional chemotherapeutics. In xenograft mice models, SLMP53-1 inhibits the growth of wt/mut p53-expressing tumors, but not of p53-null tumors, without apparent toxicity. Collectively, besides the potential use of SLMP53-1 as anticancer drug, the tryptophanol-derived oxazoloisoindolinone scaffold represents a promissing starting point for the development of effective p53-reactivating drugs

CP Violating B ---> s Gamma Decay in Supersymmetric Models

Supersymmetric models with nonuniversal down type squark masses can enrich the chiral structure and CP violating phenomena in $b\to s\gamma$ decays. Direct CP violation in $b\to s \gamma$, mixing induced CP violation in radiative $B_{d,s}$ decays (such as $B_s\to \phi \gamma$ and $B_d \to K^*_{1,2}\gamma$), and $\Lambda$ polarization in $\Lambda_b \to \Lambda \gamma$ can be substantially different from the Standard Model. Future experiements at $e^+ e^-$ and hadronic B factories will give important information on the underlying theory for radiative $b$ decays.Comment: 19 pages, 8 figures, Latex. To appear in Phys. Rev.

Trojan-like internalization of anatase titanium dioxide nanoparticles by human osteoblast cells

Dentistry and orthopedics are undergoing a revolution in order to provide more reliable, comfortable and long-lasting implants to patients. Titanium (Ti) and titanium alloys have been used in dental implants and total hip arthroplasty due to their excellent biocompatibility. However, Ti-based implants in human body suffer surface degradation (corrosion and wear) resulting in the release of metallic ions and solid wear debris (mainly titanium dioxide) leading to peri-implant inflammatory reactions. Unfortunately, our current understanding of the biological interactions with titanium dioxide nanoparticles is still very limited. Taking this into consideration, this study focuses on the internalization of titanium dioxide nanoparticles on primary bone cells, exploring the events occurring at the nano-bio interface. For the first time, we report the selective binding of calcium (Ca), phosphorous (P) and proteins from cell culture medium to anatase nanoparticles that are extremely important for nanoparticle internalization and bone cells survival. In the intricate biological environment, anatase nanoparticles form bio-complexes (mixture of proteins and ions) which act as a kind of ‘Trojan-horse’ internalization by cells. Furthermore, anatase nanoparticles-induced modifications on cell behavior (viability and internalization) could be understand in detail. The results presented in this report can inspire new strategies for the use of titanium dioxide nanoparticles in several regeneration therapies