Understanding Hope: A Review of Measurement and Construct Validity Research

Hope has been discussed by philosophers, theologians, educators, and scientists, to name but a few groups of people, over the preceding two millennia. During the last 15 years, C. R. Snyder and his colleagues at the University of Kansas have developed a theory and associated measures of the hope construct that have received extensive, detailed attention both within and outside the field of psychology. In this chapter, we describe Snyder\u27s hope model and some of the research findings that have supported the validity of this construct. Beginning with a conceptual definition of hope, we move to relevant findings about the usefulness of hope in the lives of individuals in various life arenas. We describe measures developed for assessing hope in children and adults, as well as current issues associated with the validity of hope measurement. Finally, we discuss future directions for further investigation of hope

Fertility studies on Strongsville soil

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Fertility studies on Wooster soil

Cover title.Mode of access: Internet

Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments

Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory synaptic transmission and dendritic spine morphology. We report that spinophilin is phosphorylated in vitro by protein kinase A (PKA). Phosphorylation of spinophilin was stimulated by treatment of neostriatal neurons with a dopamine D1 receptor agonist or with forskolin, consistent with spinophilin being a substrate for PKA in intact cells. Using tryptic phosphopeptide mapping, site-directed mutagenesis, and microsequencing analysis, we identified two major sites of phosphorylation, Ser-94 and Ser-177, that are located within the actin-binding domain of spinophilin. Phosphorylation of spinophilin by PKA modulated the association between spinophilin and the actin cytoskeleton. Following subcellular fractionation, unphosphorylated spinophilin was enriched in the postsynaptic density, whereas a pool of phosphorylated spinophilin was found in the cytosol. F-actin co-sedimentation and overlay analysis revealed that phosphorylation of spinophilin reduced the stoichiometry of the spinophilin-actin interaction. In contrast, the ability of spinophilin to bind to PP1 remained unchanged. Taken together, our studies suggest that phosphorylation of spinophilin by PKA modulates the anchoring of the spinophilin-PP1 complex within dendritic spines, thereby likely contributing to the efficacy and plasticity of synaptic transmission

Planetary geometry handbook: Venus positional data, 1988 - 2020, volume 2

Graphical data necessary for the analysis of planetary exploration missions to Venus are presented. Positional and geometric information spanning the time period from 1988 through 2020 is provided. The data and the usage are explained

Planetary geometry handbook: Mars positional data, 1990 - 2020, volume 3

Graphical data necessary for the analysis of planetary exploration missions to Mars are presented. Positional and geometric information spanning the time period from 1990 through 2020 is provided. The data and usage are explained

Planetary geometry handbook: Saturn positional data, 1985 - 2020, volume 5

Graphical data necessary for the analysis of planetary exploration missions to Saturn are presented. Positional and geometric information spanning the time period from 1985 through 2020 is provided. The data and their usage are explained