Theory of Nonequilibrium Spin Transport and Spin Transfer Torque in Superconducting-Ferromagnetic Nanostructures

Spin transport currents and the spin-transfer torques in voltage-biased superconducting-ferromagnetic nanopillars (SFNFS point contacts) are computed. We develop and implement an algorithm based on the Ricatti formulation of the quasiclassical theory of superconductivity to solve the time-dependent boundary conditions for the nonequilibrium Green's functions for spin transport through the ferromagnetic interfaces. A signature of the nonequilibrium torque is a component perpendicular to the plane spanned by the two ferromagnetic moments. The perpendicular component is absent in normal-metal-ferromagnetic nanopillars (NFNFN) contacts, but is shown to have the same order of magnitude as the in-plane torque for non-equilibrium SFNFS contacts. The out-of-plane torque is due to the rotation of quasiparticle spin by the exchange fields of the ferromagnetic layers. In the ballistic limit the equilibrium torque is related to the spectrum of spin-polarized Andreev bound states, while the {\sl ac} component, for small bias voltages, is determined by the nearly adiabatic dynamics of the Andreev bound states. The nonlinear voltage dependence of the non-equilibrium torque, including the subharmonic gap structure and the high-voltage asymptotics, is attributed to the interplay between multiple Andreev reflections, spin filtering and spin mixing. These properties of spin angular momentum transport may be exploited to control the state of nanomagnets.Comment: 15 pages, 14 figure

Improved flux-surface parameterization through constrained nonlinear optimization

Parameterization of magnetic flux-surfaces is often used for magnetohydrodynamic stability analysis and microturbulence modeling in tokamaks. Shape parameters for such local parameterization of a (numerical) equilibrium are traditionally computed analytically using geometrically derived quantities. However, often the shape is approximated by the average of values for different sections of the flux-surface contour or a truncated series, which does not guarantee an optimal fit. Here, instead nonlinear least squares optimization is used to compute these parameters, with a weighted sum of squared error cost function that is robust to outliers. This method results in a lower total absolute error for both the parameterization of the flux-surface contour and the poloidal magnetic field density than current methods for several parameterizations based on the well-known "Miller geometry."Furthermore, rapid convergence of shape parameters is achieved, no approximate geometric measurements of the contour are needed, and the method is applicable to any analytical shape parameterization. Validation with local, linear gyrokinetic simulations using these optimized shape parameters showed reduced root mean square errors in both the growth rate and frequency spectra when compared with simulations based on numerical equilibria. In particular, the popular Turnbull-Miller parameterization benefits from this approach, extending its usability closer toward the last-closed flux-surface for cases with minor up-down asymmetry.</p

Platelet reactivity and cardiovascular events

Cardiovascular disease are a leading cause of mortality and morbidity in the Western world. Platelets play an important role in the development of cardiovascular disease, not only in the acute onset of thrombosis after atherosclerotic plaque rupture but also in the initiation and progression of atherosclerosis and plaque formation. In recent years, the awareness has grown that platelet function may vary among individuals and that high platelet reactivity may increase the risk of cardiovascular events. This thesis addresses variation in platelet reactivity in relation to occurrence of cardiovascular events. We show that high platelet reactivity in subjects with cardiovascular disease using aspirin or clopidogrel as well as in antiplatelet drug-na_ve healthy subjects is related to the risk of cardiovascular events. We also revealed several genetic and clinical risk factors of high platelet reactivity. Moreover, we show that the 110-year old antiplatelet drug aspirin has interesting time-dependent pleiotropic effects on various pressor systems underlying blood pressure. As discussed in this thesis, although promising results have been published, routine platelet reactivity testing in daily clinical practice would currently be premature. Future studies are warranted to further investigate the clinical applicability of platelet reactivity testing in subjects at risk for cardiovascular events.Netherlands Heart Foundation Leducq Foundation for the Development of Transatlantic Networks of Excellence in Cardiovascular ResearchUBL - phd migration 201

Available energy of trapped electrons in Miller tokamak equilibria

Available energy (Æ), which quantifies the maximum amount of thermal energy that may be liberated and converted into instabilities and turbulence, has shown to be a useful metric for predicting saturated energy fluxes in trapped-electron-mode-driven turbulence. Here, we calculate and investigate the Æ in the analytical tokamak equilibria introduced by Miller et al. (Phys. Plasmas, vol. 5, issue, 4, 1998, pp. 973-978). The Æ of trapped electrons reproduces various trends also observed in experiments; negative shear, increasing Shafranov shift, vertical elongation and negative triangularity can all be stabilising, as indicated by a reduction in Æ, although it is strongly dependent on the chosen equilibrium. Comparing Æ with saturated energy flux estimates from the TGLF (trapped gyro-Landau fluid) model, we find fairly good correspondence, showcasing that Æ can be useful to predict trends. We go on to investigate Æ and find that negative triangularity is especially beneficial in vertically elongated configurations with positive shear or low gradients. Furthermore, we extract a gradient-threshold-like quantity from Æ and find that it behaves similarly to gyrokinetic gradient thresholds: it tends to increase linearly with magnetic shear, and negative triangularity leads to an especially high threshold. We next optimise the device geometry for minimal Æ and find that the optimum is strongly dependent on equilibrium parameters, for example, magnetic shear or pressure gradient. Investigating the competing effects of increasing the density gradient, the pressure gradient, and decreasing the shear, we find regimes that have steep gradients yet low Æ, and that such a regime is inaccessible in negative-triangularity tokamaks.</p

Available energy of trapped electrons in Miller tokamak equilibria

Available energy (Æ), which quantifies the maximum amount of thermal energy that may be liberated and converted into instabilities and turbulence, has shown to be a useful metric for predicting saturated energy fluxes in trapped-electron-mode-driven turbulence. Here, we calculate and investigate the Æ in the analytical tokamak equilibria introduced by Miller et al. (Phys. Plasmas, vol. 5, issue, 4, 1998, pp. 973-978). The Æ of trapped electrons reproduces various trends also observed in experiments; negative shear, increasing Shafranov shift, vertical elongation and negative triangularity can all be stabilising, as indicated by a reduction in Æ, although it is strongly dependent on the chosen equilibrium. Comparing Æ with saturated energy flux estimates from the TGLF (trapped gyro-Landau fluid) model, we find fairly good correspondence, showcasing that Æ can be useful to predict trends. We go on to investigate Æ and find that negative triangularity is especially beneficial in vertically elongated configurations with positive shear or low gradients. Furthermore, we extract a gradient-threshold-like quantity from Æ and find that it behaves similarly to gyrokinetic gradient thresholds: it tends to increase linearly with magnetic shear, and negative triangularity leads to an especially high threshold. We next optimise the device geometry for minimal Æ and find that the optimum is strongly dependent on equilibrium parameters, for example, magnetic shear or pressure gradient. Investigating the competing effects of increasing the density gradient, the pressure gradient, and decreasing the shear, we find regimes that have steep gradients yet low Æ, and that such a regime is inaccessible in negative-triangularity tokamaks.</p

Phosphoglycerate kinase acts as a futile cycle at high temperature

In (hyper)thermophilic organisms metabolic processes have to be adapted to function optimally at high temperature. We compared the gluconeogenic conversion of 3-phosphoglycerate via 1,3-bisphosphoglycerate to glyceraldehyde-3-phosphate at 30 C and at 70 C. At 30 C it was possible to produce 1,3-bisphosphoglycerate from 3-phosphoglycerate with phosphoglycerate kinase, but at 70 C, 1,3-bisphosphoglycerate was dephosphorylated rapidly to 3-phosphoglycerate, effectively turning the phosphoglycerate kinase into a futile cycle. When phosphoglycerate kinase was incubated together with glyceraldehyde 3-phosphate dehydrogenase it was possible to convert 3-phosphoglycerate to glyceraldehyde 3- phosphate, both at 30 C and at 70 C, however, at 70 C only low concentrations of product were observed due to thermal instability of glyceraldehyde 3-phosphate. Thus, thermolabile intermediates challenge central metabolic reactions and require special adaptation strategies for life at high temperature