Software performance of the ATLAS track reconstruction for LHC run 3

Charged particle reconstruction in the presence of many simultaneous proton–proton (pp) collisions in the LHC is a challenging task for the ATLAS experiment’s reconstruction software due to the combinatorial complexity. This paper describes the major changes made to adapt the software to reconstruct high-activity collisions with an average of 50 or more simultaneous pp interactions per bunch crossing (pileup) promptly using the available computing resources. The performance of the key components of the track reconstruction chain and its dependence on pile-up are evaluated, and the improvement achieved compared to the previous software version is quantified. For events with an average of 60 pp collisions per bunch crossing, the updated track reconstruction is twice as fast as the previous version, without significant reduction in reconstruction efficiency and while reducing the rate of combinatorial fake tracks by more than a factor two

Search for heavy Majorana or Dirac neutrinos and right-handed W gauge bosons in final states with charged leptons and jets in pp collisions at √s = 13 TeV with the ATLAS detector

A search for heavy right-handed Majorana or Dirac neutrinos NR and heavy right-handed gauge bosons WR is performed in events with energetic electrons or muons, with the same or opposite electric charge, and energetic jets. The search is carried out separately for topologies of clearly separated final-state products (“resolved” channel) and topologies with boosted final states with hadronic and/or leptonic products partially overlapping and reconstructed as a large-radius jet (“boosted” channel). The events are selected from pp collision data at the LHC with an integrated luminosity of 139 fb−1 collected by the ATLAS detector at √s = 13 TeV. No significant deviations from the Standard Model predictions are observed. The results are interpreted within the theoretical framework of a left-right symmetric model, and lower limits are set on masses in the heavy righthanded WR boson and NR plane. The excluded region extends to about m(WR) = 6.4 TeV for both Majorana and Dirac NR neutrinos at m(NR) < 1 TeV. NR with masses of less than 3.5 (3.6) TeV are excluded in the electron (muon) channel at m(WR) = 4.8 TeV for the Majorana neutrinos, and limits of m(NR) up to 3.6 TeV for m(WR) = 5.2 (5.0) TeV in the electron (muon) channel are set for the Dirac neutrinos. These constitute the most stringent exclusion limits to date for the model considered

Observation of four-top-quark production in the multilepton final state with the ATLAS detector

This paper presents the observation of four-top-quark (tt¯tt¯) production in proton-proton collisions at the LHC. The analysis is performed using an integrated luminosity of 140 fb−1 at a centre-of-mass energy of 13 TeV collected using the ATLAS detector. Events containing two leptons with the same electric charge or at least three leptons (electrons or muons) are selected. Event kinematics are used to separate signal from background through a multivariate discriminant, and dedicated control regions are used to constrain the dominant backgrounds. The observed (expected) significance of the measured tt¯tt¯ signal with respect to the standard model (SM) background-only hypothesis is 6.1 (4.3) standard deviations. The tt¯tt¯ production cross section is measured to be 22.5+6.6−5.5 fb, consistent with the SM prediction of 12.0±2.4 fb within 1.8 standard deviations. Data are also used to set limits on the three-top-quark production cross section, being an irreducible background not measured previously, and to constrain the top-Higgs Yukawa coupling and effective field theory operator coefficients that affect tt¯tt¯ production

Short wavelength interferometer for ITER

There is a need for a real time, reliable density measurement compatible with the restricted access and radiation environment on ITER. Due to the large plasma path length, high density and field, refraction and Faraday rotation effects makes the use of contemporary long wavelength (>50{mu}m) interferometers impractical. In this paper we consider the design of a short wavelength vibration compensated interferometer which allows operation without a prohibitively large vibration isolated structure and permits the optics to be conveniently mounted directly in or on the tokamak. A density interferometer design for ITER incorporating a 10.6 {mu}m CO{sub 2} interferometer with vibration compensation provided by a 3. 39 {mu}m HeNe laser is discussed. The proposed interferometer design requires only a small intrusion into the ITER tokamak without a large support structure, refraction and Faraday rotation problems are avoided, and it provides a density resolution of at least 0.5%. Results are presented from an interferometer installed on the DIII-D tokamak incorporating essential elements of the proposed ITER design including 10.6 and 3.39 {mu}m lasers, a retro-reflector mounted on the vacuum wall of the DIII-D tokamak and real-time density feedback control. In this paper we consider a short wavelength interferometer design that incorporates vibration compensation for use on ITER. Our primary concern is to develop a interferometer design that will produce a reliable real time density monitor. We use the ITER conceptual design activity report as the basis of the design

The multipulse Thomson scattering diagnostic on the DIII-D tokamak

This paper describes the design and operation of a 40-spatial channel Thomson scattering system that uses multiple 20 Hz Nd:YAG lasers to measure the electron temperature and density profiles periodically throughout an entire plasma discharge. Interference filter polychromators disperse the scattered light which is detected by silicon avalanche photodiodes. The measurable temperature range from 10 eV to 20 keV and the minimum detectable density is about 2 {times} 10{sup 18} m{sup {minus}3}. Laser control and data acquisition are performed in real-time by a VME-based microcomputer. Data analysis is performed by a MicroVAX 3400. Unique features of this system include burst mode'' operation, where multiple lasers are fired in rapid succession (< 10 KHz), real-time analysis capability, and laser beam quality and alignment monitoring during plasma operation. Results of component testing, calibration, and plasma operation are presented. 8 refs. 6 figs

Design and operation of the multipulse Thomson scattering diagnostic on DIII-D

This paper describes the design and operation of a 40 spatial channel Thomson scattering system that uses multiple 20 Hz Nd:YAG lasers to measure the electron temperature and density profiles periodically throughout an entire plasma discharge. As many as eight lasers may be fired alternately for an average measurement frequency of 160 Hz, or they may be fired in rapid succession (< 10 kHz), producing a burst of pulses for measuring transient events. The high spatial resolution (1.3 cm) and wide dynamic range (10 eV to 20 keV) enable this system to resolve large electron density and temperature gradients formed at the plasma edge and in the scrape-off-layer during H-mode operation. These features provide a formidable tool for studying L-H transitions, edge localized modes (ELMs), beta limits, transport, and disruptions in an efficient manner suitable for large tokamak operation where shot-to-shot scans are impractical. The scattered light is dispersed by interference filter polychromators and detected by silicon avalanche photodiodes. Laser control and data acquisition are performed in real-time by a VME based microcomputer. Data analysis is performed by a MicroVAX 3400. Additional features of this system include real-time analysis capability, full statistical treatment of error bars based on the measured background light, and laser beam quality and alignment monitoring during plasma operation. Results of component testing, calibration, plasma operation, and error analysis are presented

Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels

Protein abundance and phosphorylation convey important information about pathway activity and molecular pathophysiology in diseases including cancer, providing biological insight, informing drug and diagnostic development, and guiding therapeutic intervention. Analyzed tissues are usually collected without tight regulation or documentation of ischemic time. To evaluate the impact of ischemia, we collected human ovarian tumor and breast cancer xenograft tissue without vascular interruption and performed quantitative proteomics and phosphoproteomics after defined ischemic intervals. Although the global expressed proteome and most of the >25,000 quantified phosphosites were unchanged after 60 min, rapid phosphorylation changes were observed in up to 24% of the phosphoproteome, representing activation of critical cancer pathways related to stress response, transcriptional regulation, and cell death. Both pan-tumor and tissue-specific changes were observed. The demonstrated impact of pre-analytical tissue ischemia on tumor biology mandates caution in interpreting stress-pathway activation in such samples and motivates reexamination of collection protocols for phosphoprotein analysis