Aspects of the circulation in the Rockall Trough

An investigation is made of the circulation and structure of the water masses in the Rockall Trough in spring, combining the results of a recent synoptic survey (May 1998) with those from a high-resolution ocean circulation model. In the near-surface layer, saline flows are carried northwards by a "Shelf Edge Current" around the eastern slopes, possibly with some branching in the northern Trough. Fresher waters from the west inflow between 52 and 538N and partially mix with these saline flows in the southern Trough, so that waters of intermediate salinity are also swept northwards. In the southern approaches to the Trough, Labrador Sea Water (LSW) also flows strongly in from the west between 52 and 538N, and while much of this turns south, a proportion penetrates north to join a cyclonic gyre in the Trough extending to 56.58N. The northwestern limb of this gyre is fed by, and mixes with, more saline waters which result from overflows across the Wyville–Thomson Ridge. Furthermore, salinity and CFC data suggest episodic inflow of LSW into the central Trough. The circulation of the North East Atlantic Deep Water in the Trough follows a cyclonic pattern similar to, and lying below, that of the LSW. The Wyville–Thomson Ridge overflows in the model extend to higher densities than in the survey, are topographically steered southwestward down the Feni Ridge system, and eventually join a deep cyclonic circulation in the North East Atlantic basin. Overall, the model and the observations are in good agreement, particularly in the central Rockall Trough, and this has allowed conclusions to be drawn which are significantly more robust than those which would result from either the survey or the model alone. In particular, we have been able to infer cyclonic circulation pathways for the intermediate and deeper waters in the Rockall Trough for (we believe) the first time. The study has also contributed to an ongoing community effort to assess the realism of, and improve, our current generation of ocean circulation models

RRS Discovery Cruise 233, 23 Apr-01 Jun 1998. A Chemical and Hydrographic Atlantic Ocean Survey: CHAOS

RRS Discovery Cruise 233, CHAOS (Chemical and Hydrographic Atlantic Ocean Survey) combined a long meridional section notionally along 20°W from 20°N to Iceland with a detailed survey of the Rockall Trough. The meridional section was designed to i) establish the sources and sinks of halocarbons in subtropical and subpolar waters during spring bloom conditions; ii) to examine the decadal scale variability in the eastern Atlantic over the last 40 years by repeating the northern part of the WOCE A16 line first occupied in 1988 and again in 1993 (NATL 93), and parts of other sections occupied in 1957, 1973, 1983 and 1991; iii). to study the spreading, mixing and ventilation rates of Labrador Sea Water, Mediterranean Water, and waters of Southern Ocean origin (Antarctic Intermediate Water and Antarctic Bottom Water) which extend into the northeast Atlantic. The detailed survey of the Rockall Trough comprised 4 zonal sections notionally at 57°N, 56°N, 54°N and 52°N in order to i) make a detailed study of the water masses in the Rockall Trough with particular emphasis on their circulation/recirculation patterns ii) to re-occupy stations along the Ellett line (57°N) to continue the time series dating from 1975. The sections were completed with CTD, LADCP, tracer chemistry (CFCs, nutrients, oxygen), alkalinity and pH measurements to full depth and a suite of halocarbon measurements together with sampling for plant pigments and biological species to 200m. Continuous measurements of atmospheric halocarbons, pCO2, meteorological measurements, VM -ADCP, depth, TSG, radiometer SST and navigation data were also made. All measurements were made to WOCE standards and the final data submitted to the WOCE programme

SGNP: An Essential Stress Granule/Nucleolar Protein Potentially Involved in 5.8s rRNA Processing/Transport

Background: Stress Granules (SG) are sites of accumulation of stalled initiation complexes that are induced following a variety of cellular insults. In a genetic screen for factors involved in protecting human myoblasts from acute oxidative stress, we identified a gene encoding a protein we designate SGNP (Stress Granule and Nucleolar Protein). Methodology/Principal Findings: A gene-trap insertional mutagenesis screen produced one insertion that conferred resistance to sodium arsenite. RT-PCR/39 RACE was used to identify the endogenous gene expressed as a GFP-fusion transcript. SGNP is localized in both the cytoplasm and nucleolus and defines a non-nucleolar compartment containing 5.8S rRNA, a component of the 60S ribosomal subunit. Under oxidative stress, SGNP nucleolar localization decreases and it rapidly co-localizes with stress granules. The decrease in nucleolar SGNP following oxidative stress was accompanied by a large increase in nucleolar 5.8S rRNA. Knockdown of SGNP with shRNA increased global mRNA translation but induced growth arrest and cell death. Conclusions: These results suggest that SGNP is an essential gene that may be involved in ribosomal biogenesis and translational control in response to oxidative stress

Rounding of low serum creatinine levels and consequent impact on accuracy of bedside estimates of renal function in cancer patients

To compare glomerular filtration rate measured by technetium-99m ([Tc(99m)]) DTPA clearance with estimated creatinine clearance (CrCl) (Cockcroft and Gault (C&G) method) in patients with serum creatinine (Scr) levels 100 ml min(-1). This work indicates that when bedside estimates of renal function are calculated using the C&G formula actual Scr should be used first to estimate CrCl. If the resultant CrCl is </=100 ml min(-1), then the Scr should be rounded up to 0.06 mmol l(-1) and CrCl recalculated. Further assessment of this approach is warranted in a larger cohort of patients

Jet-Launching Structure Resolved Near the Supermassive Black Hole in M87

Approximately 10% of active galactic nuclei exhibit relativistic jets, which are powered by the accretion of matter onto supermassive black holes. Although the measured width profiles of such jets on large scales agree with theories of magnetic collimation, the predicted structure on accretion disk scales at the jet launch point has not been detected. We report radio interferometry observations, at a wavelength of 1.3 millimeters, of the elliptical galaxy M87 that spatially resolve the base of the jet in this source. The derived size of 5.5 ± 0.4 Schwarzschild radii is significantly smaller than the innermost edge of a retrograde accretion disk, suggesting that the M87 jet is powered by an accretion disk in a prograde orbit around a spinning black hole

Modeling the Spatial Distribution and Fruiting Pattern of a Key Tree Species in a Neotropical Forest: Methodology and Potential Applications

Damien Caillaud is with UT Austin and Max Planck Institute for Evolutionary Anthropology; Margaret C. Crofoot is with the Smithsonian Tropical Research Institute, Max Planck Institute for Ornithology, and Princeton University; Samuel V. Scarpino is with UT Austin; Patrick A. Jansen is with the Smithsonian Tropical Research Institute, Wageningen University, and University of Groningen; Carol X. Garzon-Lopez is with University of Groningen; Annemarie J. S. Winkelhagen is with Wageningen University; Stephanie A. Bohlman is with Princeton University; Peter D. Walsh is with VaccinApe.Background -- The movement patterns of wild animals depend crucially on the spatial and temporal availability of resources in their habitat. To date, most attempts to model this relationship were forced to rely on simplified assumptions about the spatiotemporal distribution of food resources. Here we demonstrate how advances in statistics permit the combination of sparse ground sampling with remote sensing imagery to generate biological relevant, spatially and temporally explicit distributions of food resources. We illustrate our procedure by creating a detailed simulation model of fruit production patterns for Dipteryx oleifera, a keystone tree species, on Barro Colorado Island (BCI), Panama. Methodology and Principal Findings -- Aerial photographs providing GPS positions for large, canopy trees, the complete census of a 50-ha and 25-ha area, diameter at breast height data from haphazardly sampled trees and long-term phenology data from six trees were used to fit 1) a point process model of tree spatial distribution and 2) a generalized linear mixed-effect model of temporal variation of fruit production. The fitted parameters from these models are then used to create a stochastic simulation model which incorporates spatio-temporal variations of D. oleifera fruit availability on BCI. Conclusions and Significance -- We present a framework that can provide a statistical characterization of the habitat that can be included in agent-based models of animal movements. When environmental heterogeneity cannot be exhaustively mapped, this approach can be a powerful alternative. The results of our model on the spatio-temporal variation in D. oleifera fruit availability will be used to understand behavioral and movement patterns of several species on BCI.The National Center For Ecological Analysis is supported by NSF Grant DEB-0553768, the University of California Santa Barbara and the State of California. The Forest Dynamics Plots were funded by NSF Grants to Stephen Hubbell DEB-0640386, DEB-0425651, DEB-0346488, DEB-0129874, DEB-00753102, DEB-9909347, DEB-9615226, DEB-9615226, DEB-9405933, DEB-9221033, DEB-9100058, DEB-8906869, DEB-8605042, DEB-8206992, DEB-7922197, and by the Center for Tropical Forest Science, the Smithsonian Tropical Forest Research Institute, The John D. and Catherine T. MacArthur Foundation, the Mellon Foundation and the Celera Foundation. DC is supported by NSF grant DEB-0749097 to L.A. Meyers. SS is supported by an NSF Graduate Research Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Biological Sciences, School o

Die Kritik der Politischen Ökonomie der Medien/Kommunikation: ein hochaktueller Ansatz

This debate article discusses how topical the approach of the Critique of the Political Economy of Media/Communication is today. The paper analyses the status of this field. At the international level, there is a longer tradition in the Critical Political Economy of Media/Communication, especially in the United Kingdom and North America. Since the start of the new crisis of capitalism in 2008, the interest in Marx’s works has generally increased. At the same time communicative and ideological features of societal changes’ unpredictable turbulences have become evident. This contribution introduces some specific approaches. It also discusses 14 aspects of why the complex, multidimensional, open and dynamic research approach of the critique of capitalism and society that goes back Marx’s theory remains relevant today

The spin label amino acid TOAC and its uses in studies of peptides: chemical, physicochemical, spectroscopic, and conformational aspects

We review work on the paramagnetic amino acid 2,2,6,6-tetramethyl-N-oxyl-4-amino-4-carboxylic acid, TOAC, and its applications in studies of peptides and peptide synthesis. TOAC was the first spin label probe incorporated in peptides by means of a peptide bond. In view of the rigid character of this cyclic molecule and its attachment to the peptide backbone via a peptide bond, TOAC incorporation has been very useful to analyze backbone dynamics and peptide secondary structure. Many of these studies were performed making use of EPR spectroscopy, but other physical techniques, such as X-ray crystallography, CD, fluorescence, NMR, and FT-IR, have been employed. The use of double-labeled synthetic peptides has allowed the investigation of their secondary structure. A large number of studies have focused on the interaction of peptides, both synthetic and biologically active, with membranes. In the latter case, work has been reported on ligands and fragments of GPCR, host defense peptides, phospholamban, and β-amyloid. EPR studies of macroscopically aligned samples have provided information on the orientation of peptides in membranes. More recent studies have focused on peptide–protein and peptide–nucleic acid interactions. Moreover, TOAC has been shown to be a valuable probe for paramagnetic relaxation enhancement NMR studies of the interaction of labeled peptides with proteins. The growth of the number of TOAC-related publications suggests that this unnatural amino acid will find increasing applications in the future