Probabilistic approach for analysis of strength of ceramics with different porous structure based on movable cellular automaton modeling

Movable cellular automaton method which is a computational method of particle mechanics is applied to simulating uniaxial compression of 3D porous ceramic specimens. Pores were considered explicitly by removing automata selected randomly from the original fcc packing. Distribution of pores in space, their size and the total fraction were varied. For each values of porosity there were generated several represented specimens with individual pore position in space. The resulting values of elastic modulus and strength of the specimens were scattered and well described by the Weibull distribution. We showed that to reveal dependence of the elastic and strength properties on porosity it is much better to consider not average of the values for the specimens of the same porosity, but the mathematical expectation of the corresponding Weibull distribution. It is shown that relation between mechanical properties of the material and its porosity depends significantly on pore structure. Namely, percolation transition from closed porosity to interconnected pores strongly manifests itself on strength dependence on porosity. Thus, the curve of strength versus porosity fits different equations for different kind of pore structure. Composite ceramics which pores are filled by plastic filler shows the similar behavior

Probabilistic approach for analysis of strength of ceramics with different porous structure based on movable cellular automaton modeling

Movable cellular automaton method which is a computational method of particle mechanics is applied to simulating uniaxial compression of 3D porous ceramic specimens. Pores were considered explicitly by removing automata selected randomly from the original fcc packing. Distribution of pores in space, their size and the total fraction were varied. For each values of porosity there were generated several represented specimens with individual pore position in space. The resulting values of elastic modulus and strength of the specimens were scattered and well described by the Weibull distribution. We showed that to reveal dependence of the elastic and strength properties on porosity it is much better to consider not average of the values for the specimens of the same porosity, but the mathematical expectation of the corresponding Weibull distribution. It is shown that relation between mechanical properties of the material and its porosity depends significantly on pore structure. Namely, percolation transition from closed porosity to interconnected pores strongly manifests itself on strength dependence on porosity. Thus, the curve of strength versus porosity fits different equations for different kind of pore structure. Composite ceramics which pores are filled by plastic filler shows the similar behavior

PCSK9: NEW VICTORY AND HORIZONS

The review presents the latest data from the world scientific literature of clinical studies of inhibitors protoprotein convertasesubtilisin/kexin 9 type (PCSK9). The results of the most important completed clinical trials and announcements of prospective clinical trials are presented, the completion of which is expected in the near future. The place of PCSK9 inhibitors in modern recommendations of the European and Russian Cardiological Society is highlighted.The results of studies on the efficacy and safety of PCSK9 inhibitors in selected patient groups (familial hypercholesterolemia, hypertriglyceridemia) are presented. A review of the research aimed at finding new inhibition mechanisms for PCSK9, opening new horizons in the treatment of patients with dyslipidemia

Social wellbeing of older people and their emotional burnout out

The subject of the research is evaluating social and emotional wellbeing of the elderly people. We set a goal to study social and emotional wellbeing of the aged and formulate the principles of its evaluating. The urgency of the work is that the organization of the aged's activity affords to improve the level of their emotional wellbeing

Social wellbeing of older people and their emotional burnout out

The subject of the research is evaluating social and emotional wellbeing of the elderly people. We set a goal to study social and emotional wellbeing of the aged and formulate the principles of its evaluating. The urgency of the work is that the organization of the aged's activity affords to improve the level of their emotional wellbeing

Reproductive biology of a rare species Begonia ludwigii in greenhouse conditions of the Siberian Botanical Garden of Tomsk State University

The paper presents the results of a reproductive biology study and the Begonia ludwigii seasonal development rhythm - a species classified by the International Union for Conservation of Nature as a rarity category EN (endangered species). The studies have shown that when cultivated in the Tomsk State University Siberian Botanical Garden greenhouse conditions, this species has high potential seed productivity (about 75,000 ovules per inflorescence), high fertility and pollen viability, but at the same time low true seed productivity (seed rate not more than 27%). It was established that the Begonia ludwigii seeds, in the greenhouse conditions, are tied to heterogamous pollination due to the absence of pollinating insects. The use of xenogamous artificial pollination increased the coefficient of seed productivity by almost 3 times. The paper also describes the full seasonal development rhythm, flowering biology, biomorphological features of pollen and seeds

FASN activity is important for the initial stages of the induction of senescence

Senescent cells accumulate in several tissues during ageing and contribute to several pathological processes such as ageing and cancer. Senescence induction is a complex process not well defined yet and is characterized by a series of molecular changes acquired after an initial growth arrest. We found that fatty acid synthase (FASN) levels increase during the induction of senescence in mouse hepatic stellate cells and human primary fibroblasts. Importantly, we also observed a significant increase in FASN levels during ageing in mouse liver tissues. To probe the central role of FASN in senescence induction, we used a small-molecule inhibitor of FASN activity, C75. We found that C75 treatment prevented the induction of senescence in mouse and human senescent cells. Importantly, C75 also reduced the expression of the signature SASP factors interleukin 1α (IL-1α), IL-1β and IL-6, and suppressed the secretion of small extracellular vesicles. These findings were confirmed using a shRNA targeting FASN. In addition, we find that FASN inhibition induces metabolic changes in senescent cells. Our work underscores the importance of C75 as a pharmacological inhibitor for reducing the impact of senescent cell accumulationChildren with Cancer UK (Number: 14–178)BBSRC (BB/P000223/1)The Royal Society (RG170399)Nacional Health Institute Carlos IIIMiguel-Servet (CP13-00234)MINECO (SAF2016-78666 R