A new friction factor relationship for fully developed pipe flow

The friction factor relationship for high-Reynolds-number fully developed turbulent pipe flow is investigated using two sets of data from the Princeton Superpipe in the range 31×10^3 ≤ ReD ≤ 35×10^6. The constants of Prandtl’s ‘universal’ friction factor relationship are shown to be accurate over only a limited Reynolds-number range and unsuitable for extrapolation to high Reynolds numbers. New constants, based on a logarithmic overlap in the mean velocity, are found to represent the high-Reynolds-number data to within 0.5%, and yield a value for the von Kármán constant that is consistent with the mean velocity profiles themselves. The use of a generalized logarithmic law in the mean velocity is also examined. A general friction factor relationship is proposed that predicts all the data to within 1.4% and agrees with the Blasius relationship for low Reynolds numbers to within 2.0%

Friction factors for smooth pipe flow

Friction factor data from two recent pipe flow experiments are combined to provide a comprehensive picture of the friction factor variation for Reynolds numbers from 10 to 36,000,000

Shear flow affects selective monocyte recruitment into MCP-1-loaded scaffolds

Novel cardiovascular replacements are being developed by using degradable synthetic scaffolds, which function as a temporary guide to induce neotissue formation directly in situ. Priming of such scaffolds with fast-releasing monocyte chemoattractant protein-1 (MCP-1) was shown to improve the formation of functional neoarteries in rats. However, the underlying mechanism has not been clarified. Therefore, the goal of this study was to investigate the effect of a burst-release of MCP-1 from a synthetic scaffold on the local recruitment of circulating leucocytes under haemodynamic conditions. Herein, we hypothesized that MCP-1 initiates a desired healing cascade by recruiting favourable monocyte subpopulations into the implanted scaffold. Electrospun poly(e-caprolactone) scaffolds were loaded with fibrin gel containing various doses of MCP-1 and exposed to a suspension of human peripheral blood mononuclear cells in static or dynamic conditions. In standard migration assay, a dose-dependent migration of specific CD14+ monocyte subsets was observed, as measured by flow cytometry. In conditions of pulsatile flow, on the other hand, a marked increase in immediate monocyte recruitment was observed, but without evident selectivity in monocyte subsets. This suggests that the selectivity was dependent on the release kinetics of the MCP-1, as it was overruled by the effect of shear stress after the initial burst-release. Furthermore, these findings demonstrate that local recruitment of specific MCP-1-responsive monocytes is not the fundamental principle behind the improved neotissue formation observed in long-term in vivo studies, and mobilization of MCP-1-responsive cells from the bone marrow into the bloodstream is suggested to play a predominant role in vivo

Household Water Supply Strategies in Urban Bandung, Indonesia: Findings and Implications for Future Water Access Reporting

Through structured interviews and statistical analyses, this study investigated access to water and strategies of 1227 vulnerable households in Bandung, Indonesia. The use of mixed water sources, household water treatment, and home storage suggest low trust in improved sources, and compromised safety and reliability of water. While official statistics suggest a high level of access to improved water sources, full-time access to such sources is overestimated. Integration of user behavior into the new monitoring approach for the water supply sector in the post-2015 development framework is proposed

Detection of new sources of methanol emission at 107 and 108 GHz with the Mopra telescope

A southern hemisphere survey of methanol emission sources in two millimeter wave transitions has been carried out using the ATNF Mopra millimetre telescope. Sixteen emission sources have been detected in the 3(1)-4(0)A+ transition of methanol at 107 GHz, including six new sources exhibiting class II methanol maser emission features. Combining these results with the similar northern hemisphere survey, a total of eleven 107-GHz methanol masers have been detected. A survey of the methanol emission in the 0(0)-1(-1)E transition at 108 GHz resulted in the detection of 16 sources; one of them showing maser characteristics. This is the first methanol maser detected at 108 GHz, presumably of class II. The results of LVG statistical equilibrium calculations confirm the classification of these new sources as a class II methanol masers.Comment: 11 pages, 6 figures, accepted for publication in MNRAS, mn.sty include

Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands

Purpose: In June 2013 a European Medicines Agency referral procedure concluded that diclofenac was associated with an elevated risk of acute cardiovascular events and contraindications, warnings, and changes to the product information were implemented across the European Union. This study measured the impact of the regulatory action on the prescribing of systemic diclofenac in Denmark, The Netherlands, England, and Scotland. Methods: Quarterly time series analyses measuring diclofenac prescription initiation, discontinuation and switching to other systemic nonsteroidal anti-inflammatory (NSAIDs), topical NSAIDs, paracetamol, opioids, and other chronic pain medication in those who discontinued diclofenac. Absolute effects were estimated using interrupted time series regression. Results: Overall, diclofenac prescription initiations fell during the observation periods of all countries. Compared with Denmark where there appeared to be amore limited effect, the regulatory action was associated with significant immediate reductions in diclofenac initiation in The Netherlands (−0.42%, 95% CI, −0.66% to −0.18%), England (−0.09%, 95% CI, −0.11% to −0.08%), and Scotland (−0.67%, 95% CI, −0.79% to −0.55%); and falling trends in diclofenac initiation in the Netherlands (−0.03%, 95% CI, −0.06% to −0.01% per quarter) and Scotland (−0.04%, 95% CI, −0.05% to −0.02% per quarter). There was no significant impact on diclofenac discontinuation in any country. The regulatory action was associated with modest differences in switching to other pain medicines following diclofenac discontinuation. Conclusions: The regulatory action was associated with significant reductions in overall diclofenac initiation which varied by country and type of exposure. There was no impact on discontinuation and variable impact on switching

How exactly did the Universe become neutral?

We present a refined treatment of H, He I, and He II recombination in the early Universe. The difference from previous calculations is that we use multi-level atoms and evolve the population of each level with redshift by including all bound-bound and bound-free transitions. In this framework we follow several hundred atomic energy levels for H, He I, and He II combined. The main improvements of this method over previous recombination calculations are: (1) allowing excited atomic level populations to depart from an equilibrium distribution; (2) replacing the total recombination coefficient with recombination to and photoionization from each level directly at each redshift step; and (3) correct treatment of the He I atom, including the triplet and singlet states. We find that the ionization fraction x_e = n_e/n_H is approximately 10% smaller at redshifts <~800 than in previous calculations, due to the non-equilibrium of the excited states of H, which is caused by the strong but cool radiation field at those redshifts. In addition we find that He I recombination is delayed compared with previous calculations, and occurs only just before H recombination. These changes in turn can affect the predicted power spectrum of microwave anisotropies at the few percent level. Other improvements such as including molecular and ionic species of H, including complete heating and cooling terms for the evolution of the matter temperature, including collisional rates, and including feedback of the secondary spectral distortions on the radiation field, produce negligible change to x_e. The lower x_e at low z found in this work affects the abundances of H molecular and ionic species by 10-25%. However this difference is probably not larger than other uncertainties in the reaction rates.Comment: 24 pages, including 18 figures, using emulateapj.sty, to appear in ApJ, the code recfast can be obtained at http://www.astro.ubc.ca/people/scott/recfast.html (in FORTRAN) and http://cfa-www.harvard.edu/~sasselov/rec/ (in C

The effect of collisional enhancement of Balmer lines on the determination of the primordial helium abundance

This paper describes a new determination of the primordial helium abundance (Y_P), based on the abundance analysis of five metal-poor extragalactic HII regions. For three regions of the sample (SBS 0335-052, I Zw 18, and H29) we present tailored photoionization models based on improved calculations with respect to previous models. In particular, we use the photoionization models to study quantitatively the effect of collisional excitation of Balmer lines on the determination of the helium abundance (Y) in the individual regions. This effect is twofold: first, the intensities of the Balmer lines are enhanced with respect to the pure recombination value, mimicking a higher hydrogen abundance; second, the observed reddening is larger than the true extinction, due to the differential effect of collisions on different Balmer lines. In addition to these effects, our analysis takes into account the following features of HII regions: (i) the temperature structure, (ii) the density structure, (iii) the presence of neutral helium, (iv) the collisional excitation of the HeI lines, (v) the underlying absorption of the HeI lines, and (vi) the optical thickness of the HeI lines. The object that shows the highest increase in Y after the inclusion of collisional effects in the analysis is SBS 0335-052, whose helium abundance has been revised by Delta Y = +0.0107. The revised Y values for the five objects in our sample yield an increase of +0.0035 in Y_P, giving Y_P = 0.2391 +/- 0.0020.Comment: 59 pages, 8 figures. AAS Latex. Accepted for publication in the Astrophysical Journa