Magnetoroton instabilities and static susceptibilities in higher Landau levels

We present analytical results concerning the magneto-roton instability in higher Landau levels evaluated in the single mode approximation. The roton gap appears at a finite wave vector, which is approximately independent of the LL index n, in agreement with numerical calculations in the composite-fermion picture. However, a large maximum in the static susceptibility indicates a charge density modulation with wave vectors $q_0(n)\sim 1/\sqrt{2n+1}$, as expected from Hartree-Fock predictions. We thus obtain a unified description of the leading charge instabilities in all LLs.Comment: 4 pages, 5 figure

Highly stereoselective ring expansion reactions mediated by attractive cation-n interactions

Gaining control: An attractive electrostatic force stabilizes the conformation of an intermediate (see scheme; n=nonbonded electron), thus controlling the leaving group configuration to give superior diastereoselectivity in an asymmetric ring expansion

Competition between quantum-liquid and electron-solid phases in intermediate Landau levels

On the basis of energy calculations we investigate the competition between quantum-liquid and electron-solid phases in the Landau levels n=1,2, and 3 as a function of their partial filling factor. Whereas the quantum-liquid phases are stable only in the vicinity of quantized values 1/(2s+1) of the partial filling factor, an electron solid in the form of a triangular lattice of clusters with a few number of electrons (bubble phase) is energetically favorable between these fillings. This alternation of electron-solid phases, which are insulating because they are pinned by the residual impurities in the sample, and quantum liquids displaying the fractional quantum Hall effect explains a recently observed reentrance of the integral quantum Hall effect in the Landau levels n=1 and 2. Around half-filling of the last Landau level, a uni-directional charge density wave (stripe phase) has a lower energy than the bubble phase.Comment: 12 pages, 9 figures; calculation of exact exchange potential for n=1,2,3 included, energies of electron-solid phases now calculated with the help of the exact potential, and discussion of approximation include

Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation

Differential expression and activity of the cellular energy regulators GAPDH and NDPK underlie reactive oxygen species–induced damage in the mouse liver and may contribute to human liver disease progression

Discharge Estimation From Dense Arrays of Pressure Transducers

In situ river discharge estimation is a critical component of studying rivers. A dominant method for establishing discharge monitoring in situ is a temporary gauge, which uses a rating curve to relate stage to discharge. However, this approach is constrained by cost and the time to develop the stage-discharge rating curve, as rating curves rely on numerous flow measurements at high and low stages. Here, we offer a novel alternative approach to traditional temporary gauges: estimating Discharge via Arrays of Pressure Transducers (DAPT). DAPT uses a Bayesian discharge algorithm developed for the upcoming Surface Water Ocean Topography satellite (SWOT) to estimate in situ discharge from automated water surface elevation measurements. We conducted sensitivity tests over 4,954 model runs on five gauged rivers and conclude that the DAPT method can robustly reproduce discharge with an average Nash-Sutcliffe Efficiency (NSE) of 0.79 and Kling-Gupta Efficiency of 0.78. Further, we find that the DAPT method estimates discharge similarly to an idealized temporary gauge created from the same input data (NSE differences of less than 0.1), and that results improve significantly with accurate priors. Finally, we test the DAPT method in nine poorly gauged rivers in a realistic and complex field setting in the Peace-Athabasca Delta, and show that the DAPT method largely outperforms a temporary gauge in this time and budget constrained setting. We therefore recommend DAPT as an effective tool for in situ discharge estimation in cases where there is not enough time or resources to develop a temporary gauge

Deep hanging out in the arts: an anthropological approach to capturing cultural value

This article presents the findings of an Arts and Humanities Research Council (AHRC) funded project carried out from September 2013 to March 2014 by five researchers at the University of Leeds (UK), who paired off with five audience-participants and engaged in a process of “deep hanging out” (Geertz 1998) at events curated as part of Leeds’ annual LoveArts festival. As part of AHRC’s Cultural Value project, the overarching aim of the research was to produce a rich, polyvocal, evocative and complex account of cultural value by co-investigating arts engagement with audience-participants. Findings suggested that both the methods and purpose of knowing about cultural value impact significantly on any exploration of cultural experience. Fieldwork culminated in the apparent paradox that we know, and yet still don’t seem to know, the value and impact of the arts. Protracted discussions with the participants suggested that this paradox stemmed from a misplaced focus on knowledge; that instead of striving to understand and rationalize the value of the arts, we should instead aim to feel and experience it. During a process of deep hanging out, our participants revealed the limitations of language in capturing the value of the arts, yet confirmed perceptions of the arts as a vehicle for developing self-identity and -expression and for living a better life. These findings suggest that the Cultural Value debate needs to be reframed from what is currently an interminable epistemological obsession (that seeks to prove and evidence the value of culture) into a more complex phenomenological question, which asks how people experience the arts and culture and why people want to understand its value. This in turn implies a re-conceptualization of the relationships between artists or arts organisations and their publics, based on a more relational form of engagement and on a more anthropological approach to capturing and co-creating cultural value

Fruit production, migrant bird visitation, and seed dispersal of Guarea glabra in Panama

The relationship between bird visitation and the size of the available fruit crop was studied at an understory tree ( Guarea glabra Vahl, Meliaceae) in the tropical wet forest of Barro Colorado Island, Panama Canal Zone. Twelve resident species and seven North American migrant species fed on the Bright orange arilloids (seeds with arils), which were not depleted during the normal fruiting period. The number of individual visitors, the number of visiting species, and the number of seeds removed increased linearly with the size of the available fruit crop. The proportion of seeds removed did not increase with the size of the available fruit crop, indicating that dispersal is a function of the number of fruit available and not a disproportionate function of large fruit displays. Four species of North American migrants ( Myiarchus crinitus, Catharus ustulatus, Vireo olivaceus , and Vermivora peregrina ) accounted for 70% of the visits and 60% of the seeds removed from the trees. No resident species visited Guarea as frequently as any one of these migrants. There was no indication that any single visitor was dependent on this tree for nutrition, nor that the tree was dependent upon any single species for dispersal. We hypothesize that the fruiting season of G. glabra is adaptively synchronized with northward migration of opportunistically frugivorous North American birds.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47724/1/442_2004_Article_BF00348067.pd

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Findings: Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research