Apollo experience report: Spacecraft structure subsystem

The flightworthiness of the Apollo spacecraft structure was verified primarily through a rigorous, vehicle level, ground test program and flight tests. The failures and anomalies encountered during this testing were the major factors considered in determining necessary modifications to the basic design of the spacecraft structure. In this report, these failures, their causes, and their resolutions are discussed. A description of the spacecraft structure and discussions of the ground and flight test programs are presented

Gene expression analysis of bovine embryonic disc, trophoblast and parietal hypoblast at the start of gastrulation

In cattle early gastrulation-stage embryos (Stage 5), four tissues can be discerned: (i) the top layer of the embryonic disc consisting of embryonic ectoderm (EmE); (ii) the bottom layer of the disc consisting of mesoderm, endoderm and visceral hypoblast (MEH); (iii) the trophoblast (TB); and (iv) the parietal hypoblast. We performed microsurgery followed by RNA-seq to analyse the transcriptome of these four tissues as well as a developmentally earlier pre-gastrulation embryonic disc. The cattle EmE transcriptome was similar at Stages 4 and 5, characterised by the OCT4/SOX2/NANOG pluripotency network. Expression of genes associated with primordial germ cells suggest their presence in the EmE tissue at these stages. Anterior visceral hypoblast genes were transcribed in the Stage 4 disc, but no longer by Stage 5. The Stage 5 MEH layer was equally similar to mouse embryonic and extraembryonic visceral endoderm. Our data suggest that the first mesoderm to invaginate in cattle embryos is fated to become extraembryonic. TGFβ, FGF, VEGF, PDGFA, IGF2, IHH and WNT signals and receptors were expressed, however the representative members of the FGF families differed from that seen in equivalent tissues of mouse embryos. The TB transcriptome was unique and differed significantly from that of mice. FGF signalling in the TB may be autocrine with both FGFR2 and FGF2 expressed. Our data revealed a range of potential inter-tissue interactions, highlighted significant differences in early development between mice and cattle and yielded insight into the developmental events occurring at the start of gastrulation

Twin prime correlations from the pair correlation of Riemann zeros

We establish, via a formal/heuristic Fourier inversion calculation, that the Hardy-Littlewood twin prime conjecture is equivalent to an asymptotic formula for the two-point correlation function of Riemann zeros at a height $E$ on the critical line. Previously it was known that the Hardy-Littlewood conjecture implies the pair correlation formula, and we show that the reverse implication also holds. A smooth form of the Hardy-Littlewood conjecture is obtained by inverting the $E \rightarrow \infty$ limit of the two-point correlation function and the precise form of the conjecture is found by including asymptotically lower order terms in the two-point correlation function formula.Comment: 11 page

Portable Perimetry Using Eye-Tracking on a Tablet Computer—A Feasibility Assessment

Purpose: Visual field (VF) examination by standard automated perimetry (SAP) is an important method of clinical assessment. However, the complexity of the test, and its use of bulky, expensive equipment makes it impractical for case-finding. We propose and evaluate a new approach to paracentral VF assessment that combines an inexpensive eye-tracker with a portable tablet computer (“Eyecatcher”). Methods: Twenty-four eyes from 12 glaucoma patients, and 12 eyes from six age-similar controls were examined. Participants were tested monocularly (once per eye), with both the novel Eyecatcher test and traditional SAP (HFA SITA standard 24-2). For Eyecatcher, the participant's task was to simply to look at a sequence of fixed-luminance dots, presented relative to the current point of fixation. Start and end fixations were used to determine locations where stimuli were seen/unseen, and to build a continuous map of sensitivity loss across a VF of approximately 20°. Results: Eyecatcher was able to clearly separate patients from controls, and the results were consistent with those from traditional SAP. In particular, mean Eyecatcher scores were strongly correlated with mean deviation scores (r2 = 0.64, P < 0.001), and there was good concordance between corresponding VF locations (∼84%). Participants reported that Eyecatcher was more enjoyable, easier to perform, and less tiring than SAP (all P < 0.001). Conclusions: Portable perimetry using an inexpensive eye-tracker and a tablet computer is feasible, although possible means of improvement are suggested. Translational Relevance: Such a test could have significant utility as a case finding device

Combined pyrolysis and radiochemical gas chromatography for studying the thermal degradation of polymers

Pyrolysis gas chromatography and radioactive tracer techniques have been used independently to study the thermal degradation of polymers. In these laboratories the two techniques have been combined to elucidate some of the mechanisms of the thermal degradation of epoxy resins and polyimides. This paper describes the apparatus developed for this work

Development of SCR Aircraft takeoff and landing procedures for community noise abatement and their impact on flight safety

Piloted simulator studies to determine takeoff and landing procedures for a supersonic cruise transport concept that result in predicted community noise levels which meet current Federal Aviation Administration (FAA) standards are discussed. The results indicate that with the use of advanced procedures, the subject simulated aircraft meets the FAA traded noise levels during takeoff and landing utilizing average flight crew skills. The advanced takeoff procedures developed involved violating three of the current Federal Aviation Regulations (FAR) noise test conditions. These were: (1) thrust cutbacks at altitudes below 214 meters (700 ft); (2) thrust cutback level below those presently allowed; and (3) configuration change, other than raising the landing gear. It was not necessary to violate any FAR noise test conditions during landing approach. It was determined that the advanced procedures developed do not compromise flight safety. Automation of some of the aircraft functions reduced pilot workload, and the development of a simple head-up display to assist in the takeoff flight mode proved to be adequate

Use of a transcendental approximation in transient conduction analysis

Variation method applied to transient thermal conductivity in semiinfinite slab with nonlinear boundary conditio

Anticipated and Actual Bequests

This paper uses data on anticipated bequests from two waves of the Health and Retirement Study and the Asset and Health Dynamics of the Oldest Old (AHEAD), and on actual bequests from AHEAD. Actual bequests were measured in exit interviews given by proxy respondents for 774 AHEAD respondents who died between waves 1 and 2. Because the exit interview is representative of the elderly population, the distribution of estate values is quite different from that obtained from estate records, which represent just a wealthy subset of the population. Anticipated bequests were measured by the subjective probability of leaving bequests. Between waves 1 and 2, increases in bequest probabilities were associated with increases in the subjective probability of surviving, increments in household wealth, and widowing while out-of-pocket medical expenses reduced the likelihood of a bequest. By comparing bequest probabilities with baseline wealth we were able to test a main prediction of the life-cycle model, that individuals will dissave at advanced old-age. The AHEAD respondents anticipate substantial dissaving before they die.