Internal Migration and Regional Population Dynamics in Europe: Netherlands Case Study

This report summarises the presentations made and discussions held at the Second of the ESRC/JISC Workshops Planning for the 2001 Census. The report presents views of expert census users and summarises the recommendations to ESRC and JISC about what kinds of data from the 2001 Census should be requested from the UK Census Offices. The Workshops are supported by ESRC Award H507265031. The Census of Population is a very large exercise in data collection and processing. In 2001 some 25 million households in the United Kingdom will be contacted and asked to provide answers to a simple questionnaire of 25 to 30 questions. Such a task is likely to cost £125-150 millions to the Census Offices. Purchase of the data for academic research purposes is likely to cost ESRC and JISC some £1.5 to £2 millions directly and an equivalent amount indirectly on support over the following decade. It is therefore essential that the Population Census is very carefully planned beforehand and that the greatest possible value is extracted from the data collected. This edited collection of papers reports on presentations and discussions in the Fourth and Final Workshop in the series Workshops Planning for the 2001 Census - Determining Academic Community Needs and Strategy. The Fourth Workshop was entitled The 2001 Census: What do we really really want?. The aim was to gather together and summarise the principal recommendations of the First (Geography), Second (Interfaces) and Third (Special Data Sets) Workshops. The Workshop was twinned with another on The One Number Census: A Research Workshop, organised by Ludi Simpson. The One Number Census project is a major undertaking by the Census Offices to deal with anticipated underenumeration by estimating how many households and people are missed by the standard enumeration. Part 1 of the report on Look Up Tables and Area Statistics contains chapters by David Martin on the output geography proposals for 2001, by Seraphim Alvanides and Stan Openshaw on further developments to the methods being used to define output areas and by Bob Barr on what the Look Up Tables associated with the 2001 Census should be like. These chapters contain key recommendations on census output geography. Part 2 of the report puts forward recommendations for the preparation of Microdata - Samples of Anonymised Records and Longitudinal Data from the 2001 Census. Angela Dale summarises the conclusions of the SARs Sub-Group of the Census Offices' Output Working Group. Brian Dodgeon and Heather Joshi document the essential features of the 2001 Census Link to the Longitudinal Study and make a final plea for some new questions. Part 3 of the report reviews proposals for the improvement of Interaction Statistics from the 2001 UK Census. Paul Boyle and Phil Rees make radical proposals for revamping the provision of Migration Statistics. Martin Frost concentrates on ways of improving the accuracy of the Workplace Statistics. The fourth part of the report gathers together recommendations about information technology interfaces to census data, arguing that the tools and infrastructure are now in place to make networked and standalone access to the different types of data so much easier for the new user. Donald Morse and Alistair Towers review what interfaces to boundary data should look like. James Harris argues for the development of interfaces based on general data standards and the Web to access census statistics. Oliver Duke-Williams outlines how complex migration statistics can be presented for access in a simpler and easier to use interface. Ian Turton identifies how current software developments in Java programming will make possible delivering easy to use interfaces to microdata very simple. Finally, Paul Williamson describes a design of a data dictionary for all census data sets. In Part 5, recommendations are summarised. Phil Rees reports on the views of 140 respondents drawn from the different corners of the academic community. The final pages try to draw out some general points from the very large number of recommendations made in the Fourth Workshop

Integration of Telehealth Education into the Health Care Provider Curriculum: A Review

Introduction: Telehealth is a rapidly expanding health care delivery modality with increasing utility in the health care community. It is imperative that telehealth education is provided during the training of health care providers to ensure the proper usage and application of this health care delivery system. A comprehensive literature review of telehealth education integrated into the curricula of physician, physician assistant, and advanced practiced registered nurse training programs has not been reported to date. Materials and Methods: An electronic literature search was performed using Scopus®, PubMed, and 17 of the 35 databases on the EBSCOHost platform. We included studies where telehealth concepts and components were integrated in the curriculum for primary care students. We extracted information pertinent to understanding the scope and sustainability of the curriculum and tabulated the results. Results: After a full-text screening of 164 articles and critically analyzing 34, eight articles were included in this review. Comparison of these articles showed no consistency in how telehealth was integrated into the various health care curricula. Content delivered usually included basic telehealth information, however, the depth and breadth of content varied significantly based on the interventions. Discussion: For the articles included in this review, there were no formal study designs regarding basic telehealth educational integration or competencies. While authors recommended conducting evaluation and determining the effectiveness of the interventions, they did not provide a clear picture as to how these efforts should be conducted. Conclusions: In addition to developing a standardized telehealth curriculum, national competencies need to be created, which will guide the development of standardized curriculum across health care training programs

NCS-1 Inhibits insulin stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase dependent pathway

Expression of NCS-1 (neuronal calcium sensor-1, also termed frequenin) in 3T3L1 adipocytes strongly inhibited insulin-stimulated translocation of GLUT4 and insulin-responsive aminopeptidase. The effect of NCS-1 was specific for GLUT4 and the insulin-responsive aminopeptidase translocation as there was no effect on the trafficking of the cation-independent mannose 6-phosphate receptor or the GLUT1 glucose transporter isoform. Moreover, NCS-1 showed partial colocalization with GLUT4-EGFP in the perinuclear region. The inhibitory action of NCS-1 was independent of calcium sequestration since neither treatment with ionomycin nor endothelin-1, both of which elevated the intracellular calcium concentration, restored insulin-stimulated GLUT4 translocation. Furthermore, NCS-1 did not alter the insulin-stimulated protein kinase B (PKB/Akt) phosphorylation or the recruitment of Cbl to the plasma membrane. In contrast, expression of the NCS-1 effector phosphatidylinositol 4-kinase (PI 4-kinase) inhibited insulin-stimulated GLUT4 translocation, whereas co-transfection with an inactive PI 4-kinase mutant prevented the NCS-1-induced inhibition. These data demonstrate that PI 4-kinase functions to negatively regulate GLUT4 translocation through its interaction with NCS-1

Cranial nerve outcomes in regionally recurrent head & neck melanoma after sentinel lymph node biopsy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/156007/1/lary28243.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/156007/2/lary28243_am.pd

The acheulean handaxe : More like a bird's song than a beatles' tune?

© 2016 Wiley Periodicals, Inc. KV is supported by the Netherlands Organization for Scientific Research. MC is supported by the Canada Research Chairs Program, the Social Sciences and Humanities Research of Canada, the Canada Foundation for Innovation, the British Columbia Knowledge Development Fund, and Simon Fraser UniversityPeer reviewedPublisher PD

Conducting retrospective impact analysis to inform a medical research charity’s funding strategies: The case of Asthma UK

© 2013 Hanney et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.BACKGROUND: Debate is intensifying about how to assess the full range of impacts from medical research. Complexity increases when assessing the diverse funding streams of funders such as Asthma UK, a charitable patient organisation supporting medical research to benefit people with asthma. This paper aims to describe the various impacts identified from a range of Asthma UK research, and explore how Asthma UK utilised the characteristics of successful funding approaches to inform future research strategies. METHODS: We adapted the Payback Framework, using it both in a survey and to help structure interviews, documentary analysis, and case studies. We sent surveys to 153 lead researchers of projects, plus 10 past research fellows, and also conducted 14 detailed case studies. These covered nine projects and two fellowships, in addition to the innovative case studies on the professorial chairs (funded since 1988) and the MRC-Asthma UK Centre in Allergic Mechanisms of Asthma (the ‘Centre’) which together facilitated a comprehensive analysis of the whole funding portfolio. We organised each case study to capture whatever academic and wider societal impacts (or payback) might have arisen given the diverse timescales, size of funding involved, and extent to which Asthma UK funding contributed to the impacts. RESULTS: Projects recorded an average of four peer-reviewed journal articles. Together the chairs reported over 500 papers. All streams of funding attracted follow-on funding. Each of the various categories of societal impacts arose from only a minority of individual projects and fellowships. Some of the research portfolio is influencing asthma-related clinical guidelines, and some contributing to product development. The latter includes potentially major breakthroughs in asthma therapies (in immunotherapy, and new inhaled drugs) trialled by university spin-out companies. Such research-informed guidelines and medicines can, in turn, contribute to health improvements. The role of the chairs and the pioneering collaborative Centre is shown as being particularly important. CONCLUSIONS: We systematically demonstrate that all types of Asthma UK’s research funding assessed are making impacts at different levels, but the main societal impacts from projects and fellowships come from a minority of those funded. Asthma UK used the study’s findings, especially in relation to the Centre, to inform research funding strategies to promote the achievement of impact.This study was funded by Asthma UK

Cost-Effectiveness Analysis of Four Simulated Colorectal Cancer Screening Interventions, North Carolina

Colorectal cancer (CRC) screening rates are suboptimal, particularly among the uninsured and the under-insured and among rural and African American populations. Little guidance is available for state-level decision makers to use to prioritize investment in evidence-based interventions to improve their population’s health. The objective of this study was to demonstrate use of a simulation model that incorporates synthetic census data and claims-based statistical models to project screening behavior in North Carolina

Learning From Early Attempts to Generalize Darwinian Principles to Social Evolution

Copyright University of Hertfordshire & author.Evolutionary psychology places the human psyche in the context of evolution, and addresses the Darwinian processes involved, particularly at the level of genetic evolution. A logically separate and potentially complementary argument is to consider the application of Darwinian principles not only to genes but also to social entities and processes. This idea of extending Darwinian principles was suggested by Darwin himself. Attempts to do this appeared as early as the 1870s and proliferated until the early twentieth century. But such ideas remained dormant in the social sciences from the 1920s until after the Second World War. Some lessons can be learned from this earlier period, particularly concerning the problem of specifying the social units of selection or replication

Book reviews

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44495/1/10745_2005_Article_BF01880261.pd