Infrared coronal emission lines and the possibility of their maser emission in Seyfert nuclei

Energetic emitting regions have traditionally been studied via x-ray, UV and optical emission lines of highly ionized intermediate mass elements. Such lines are often referred to as 'coronal lines' since the ions, when produced by collisional ionization, reach maximum abundance at electron temperatures of approx. 10(exp 5) - 10(exp 6) K typical of the sun's upper atmosphere. However, optical and UV coronal lines are also observed in a wide variety of Galactic and extragalactic sources including the Galactic interstellar medium, nova shells, supernova remnants, galaxies and QSOs. Infrared coronal lines are providing a new window for observation of energetic emitting regions in heavily dust obscured sources such as infrared bright merging galaxies and Seyfert nuclei and new opportunities for model constraints on physical conditions in these sources. Unlike their UV and optical counterparts, infrared coronal lines can be primary coolants of collisionally ionized plasmas with 10(exp 4) less than T(sub e)(K) less than 10(exp 6) which produce little or no optical or shorter wavelength coronal line emission. In addition, they provide a means to probe heavily dust obscured emitting regions which are often inaccessible to optical or UV line studies. In this poster, we provide results from new model calculations to support upcoming Infrared Space Observatory (ISO) and current ground-based observing programs involving infrared coronal emission lines in AGN. We present a complete list of infrared (lambda greater than 1 micron) lines due to transitions within the ground configurations 2s(2)2p(k) and 3s(2)3p(k) (k = 1 to 5) or the first excited configurations 2s2p and 3s3p of highly ionized (x greater than or equal to 100 eV) astrophysically abundant (n(X)/n(H) greater than or equal to 10(exp -6)) elements. Included are approximately 74 lines in ions of O, Ne, Na, Mg, Al, Si, S, Ar, Ca, Fe, and Ni spanning a wavelength range of approximately 1 - 280 microns. We present new results from detailed balance calculations, new critical densities for collisional de-excitation, intrinsic photon rates, branching ratios, and excitation temperatures for the majority of the compiled transitions. The temperature and density parameter space for dominant cooling via infrared coronal lines is presented, and the relationship of infrared to optical coronal lines is discussed

Modelling Molecular Motors as Folding-Unfolding Cycles

We propose a model for motor proteins based on a hierarchical Hamiltonian that we have previously introduced to describe protein folding. The proposed motor model has high efficiency and is consistent with a linear load-velocity response. The main improvement with respect to previous models is that this description suggests a connection between folding and function of allosteric proteins.Comment: 5 pages RevTeX, 2 Postscript figures, replaced due to LaTeX proble

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.

Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin, a cytotoxic and anti-adipogenic natural product whose molecular mode of action was unknown. The new ternatin variants are cytotoxic toward cancer cells, with up to 500-fold greater potency than ternatin itself. Using a ternatin photo-affinity probe, we identify the translation elongation factor-1A ternary complex (eEF1A·GTP·aminoacyl-tRNA) as a specific target and demonstrate competitive binding by the unrelated natural products, didemnin and cytotrienin. Mutations in domain III of eEF1A prevent ternatin binding and confer resistance to its cytotoxic effects, implicating the adjacent hydrophobic surface as a functional hot spot for eEF1A modulation. We conclude that the eukaryotic elongation factor-1A and its ternary complex with GTP and aminoacyl-tRNA are common targets for the evolution of cytotoxic natural products

Synchronization of active mechanical oscillators by an inertial load

Motivated by the operation of myogenic (self-oscillatory) insect flight muscle, we study a model consisting of a large number of identical oscillatory contractile elements joined in a chain, whose end is attached to a damped mass-spring oscillator. When the inertial load is small, the serial coupling favors an antisynchronous state in which the extension of one oscillator is compensated by the contraction of another, in order to preserve the total length. However, a sufficiently massive load can sychronize the oscillators and can even induce oscillation in situations where isolated elements would be stable. The system has a complex phase diagram displaying quiescent, synchronous and antisynchrononous phases, as well as an unsual asynchronous phase in which the total length of the chain oscillates at a different frequency from the individual active elements.Comment: 5 pages, 4 figures, To appear in Phys. Rev. Let

Infrared Observations of the Helix Planetary Nebula

We have mapped the Helix (NGC 7293) planetary nebula (PN) with the IRAC instrument on the Spitzer Space Telescope. The Helix is one of the closest bright PNs and therefore provides an opportunity to resolve the small-scale structure in the nebula. The emission from this PN in the 5.8 and 8 μm IRAC bands is dominated by the pure rotational lines of molecular hydrogen, with a smaller contribution from forbidden line emission such as [Ar III] in the ionized region. The IRAC images resolve the "cometary knots," which have been previously studied in this PN. The "tails" of the knots and the radial rays extending into the outer regions of the PN are seen in emission in the IRAC bands. IRS spectra on the main ring and the emission in the IRAC bands are consistent with shock-excited H_2 models, with a small (~10%) component from photodissociation regions. In the northeast arc, the H_2 emission is located in a shell outside the Hα emission

The Role of Mycobacteriosis in Elevated Natural Mortality of Chesapeake Bay Striped Bass: Developing Better Models for Stock Assessment and Management : a final report

Mycobacteriosis is a chronic systemic disease of fishes caused by bacteria belonging to the genus Mycobacterium. The disease currently affects striped bass throughout Chesapeake Bay and prevalence is higher than 90% in certain age groups. Two recently described species, M. shottsii and M. pseudoshottsii, are the most common isolates obtained from diseased fish and are considered the primary etiologic agents. Recent indications that natural mortality (M) has become elevated in Chesapeake Bay striped bass and that mycobacteriosis may be the underlying cause, has caused concern among fishermen, fisheries managers and scientists. However, fundamental questions, such as transmission mode, duration of disease states, impacts of disease on fish movements, feeding and reproduction remain unanswered. A central unanswered question is whether the disease causes mortality. Therefore, the aim of this study was to develop new approaches for estimating the contribution of mycobacteriosis to natural mortality in the striped bass (e.g., disease-associated mortality component of M)