Triplets of Quasars at high redshift I: Photometric data

We have conducted an optical and infrared imaging in the neighbourhoods of 4 triplets of quasars. R, z', J and Ks images were obtained with MOSAIC II and ISPI at Cerro Tololo Interamerican Observatory. Accurate relative photometry and astrometry were obtained from these images for subsequent use in deriving photometric redshifts. We analyzed the homogeneity and depth of the photometric catalog by comparing with results coming from the literature. The good agreement shows that our magnitudes are reliable to study large scale structure reaching limiting magnitudes of R = 24.5, z' = 22.5, J = 20.5 and Ks = 19.0. With this catalog we can study the neighbourhoods of the triplets of quasars searching for galaxy overdensities such as groups and galaxy clusters.Comment: The paper contains 12 figures and 3 table

Traumatic brain injury: Age at injury influences dementia risk after TBI

Traumatic brain injury (TBI) is increasingly recognized as a risk factor for dementia. New data provide further support for this association and demonstrate the influence of age at injury and injury severity on dementia risk after TBI, revealing that even mild TBI increases dementia risk in those aged ≥65 years

Time domain computational modelling of 1D arterial networks in monochorionic placentas

Published versio

The SMC SNR 1E0102.2-7219 as a Calibration Standard for X-ray Astronomy in the 0.3-2.5 keV Bandpass

The flight calibration of the spectral response of CCD instruments below 1.5 keV is difficult in general because of the lack of strong lines in the on-board calibration sources typically available. We have been using 1E 0102.2-7219, the brightest supernova remnant in the Small Magellanic Cloud, to evaluate the response models of the ACIS CCDs on the Chandra X-ray Observatory (CXO), the EPIC CCDs on the XMM-Newton Observatory, the XIS CCDs on the Suzaku Observatory, and the XRT CCD on the Swift Observatory. E0102 has strong lines of O, Ne, and Mg below 1.5 keV and little or no Fe emission to complicate the spectrum. The spectrum of E0102 has been well characterized using high-resolution grating instruments, namely the XMM-Newton RGS and the CXO HETG, through which a consistent spectral model has been developed that can then be used to fit the lower-resolution CCD spectra. We have also used the measured intensities of the lines to investigate the consistency of the effective area models for the various instruments around the bright O (~570 eV and 654 eV) and Ne (~910 eV and 1022 eV) lines. We find that the measured fluxes of the O VII triplet, the O VIII Ly-alpha line, the Ne IX triplet, and the Ne X Ly-alpha line generally agree to within +/-10 % for all instruments, with 28 of our 32 fitted normalizations within +/-10% of the RGS-determined value. The maximum discrepancies, computed as the percentage difference between the lowest and highest normalization for any instrument pair, are 23% for the O VII triplet, 24% for the O VIII Ly-alpha line, 13% for the Ne IX triplet, and 19% for the Ne X Ly-alpha line. If only the CXO and XMM are compared, the maximum discrepancies are 22% for the O VII triplet, 16% for the O VIII Ly-alpha line, 4% for the Ne IX triplet, and 12% for the Ne X Ly-alpha line.Comment: 16 pages, 11 figures, to be published in Proceedings of the SPIE 7011: Space Telescopes and Instrumentation II: Ultraviolet to Gamma Ray 200

Effect of Oral Rinsing with Pre-Workout on Cycling Time Trial Performance

There is evidence that oral rinsing with a carbohydrate solution can have similar effects on aerobic performance compared to consuming the beverage, but less is known of sugar-free and pre-workout beverages. PURPOSE: to examine the effects of oral rinsing with a pre-workout supplement on aerobic performance. METHODS: After recording age (32.4±12.1 yrs), height (173.2±11.2 cm), and weight (76.8±14.8 kg), eleven participants rinsed 10 sec with either 2.5 oz. of carbohydrate (CHO), sugar-free pre-workout (PWO), or a sugar-free placebo (CN) beverage. Participants were interfaced with a metabolic analyzer and resting measurements were collected after two minutes. Participants then cycled for 5 minutes on a stationary bike as a warm up, with load being adjusted to reach 70% of max heart rate. Participants then rode for 15 minutes at this intensity after which they received a five minute break followed by another 10 second oral rinse of the same solution. This was followed by a time trial, which consisted of 15 minutes on the bike at maximum intensity. This was a counter-balanced, repeated-measures design where participants performed the trials no fewer than two days and no more than seven days apart. Repeated measures ANOVA were used to determine differences in performances and physiological responses between trials, with Alpha set at .05 for all tests. RESULTS: There was no significant difference in distance during the time trial between CHO (7.7±1.2 km), PWO (7.6±1.4 km), and CN (7.4±1.2), F(2,9)=0.95, P=.419. There was also no significant difference in VO2 during the time trial between CHO (2.02±0.58 L/min), PWO (1.94±0.58 L/min), and CN (2.29±1.29 L/min), F(2,9) = 1.0, P=.388, as well as heart rate between CHO (155.6±18.2 b/min), PWO (152.6±19.8 b/min), and CN (150.3±19.1 b/min), F(2,9)=1.5, P=.260. Finally, there was no significant difference in RPE between CHO (14.0±2.6), PWO (13.6±2.3), and CN (13.6±2.1), F(2,9)=.23, P=.797. CONCLUSION: The results of the study suggest that oral rinsing does not enhance performance on a 15-min cycling time trial. For a short, acute bout of intense aerobic exercise, oral rinsing with a CHO or PWO drink will not provide any benefit

Three Interventions for Financial Therapy: Fostering an Examination of Financial Behaviors and Beliefs

Three interventions that address the emotional components of handling finances are proposed. Drawn from a stepwise model of financial therapy, the three interventions introduced here have the specific aim of incorporating the emotional attributes of traditional financial behaviors and beliefs. First, the Financial Genogram identifies family of origin issues that may affect financial behaviors; second, the Financial Landscape intervention is used when emotional stress occurs in collecting and examining financial documents; and third, the Financial Mirror broadens clients’ perspectives of their financial behaviors. Issues in future research and implementation of the Five Step model are addressed in treating financially distressed clients

Seasonal patterns of oral antihistamine and intranasal corticosteroid purchases from Australian community pharmacies : a retrospective observational study

Acknowledgments The abstract of this paper was presented at the Respiratory Effectiveness Group 2016 Annual Summit as a poster presentation with interim findings. The poster’s abstract was published in “Poster Abstracts” in The Journal of Thoracic Disease (Vol. 8, Supplement 5, 5 July 2016). http://jtd.amegroups.com/article/view/8504.Peer reviewedPublisher PD

Abnormal T Cell Frequencies, Including Cytomegalovirus-Associated Expansions, Distinguish Seroconverted Subjects at Risk for Type 1 Diabetes

We analyzed T cell subsets from cryopreserved PBMC obtained from the TrialNet Pathway to Prevention archives. We compared subjects who had previously seroconverted for one or more autoantibodies with non-seroconverted, autoantibody negative individuals. We observed a reduced frequency of MAIT cells among seroconverted subjects. Seroconverted subjects also possessed decreased frequencies of CCR4-expressing CD4 T cells, including a regulatory-like subset. Interestingly, we found an elevation of CD57+, CD28-, CD127-, CD27- CD8 T cells (SLEC) among seroconverted subjects that was most pronounced among those that progressed to disease. The frequency of these SLEC was strongly correlated with CMV IgG abundance among seroconverted subjects, associated with IA-2 levels, and most elevated among CMV+ seroconverted subjects who progressed to disease. Combined, our data indicate discrete, yet profound T cell alterations are associated with islet autoimmunity among at-risk subjects

Releasing The Anti-inflammatory Potential of Paralysed Skeletal Muscle: The Circulating Cytokine Response to Voluntary Upper-limb Exercise With/Without The Addition of Functional Electrical Stimulation (FES)-evoked Lower-limb Contractions

Skeletal muscle is a rich store of inflammatory mediating ‘myokines’. Following release from contracting muscle, the myokine interleukin-6 (IL-6) promotes a circulating anti-inflammatory environment associated with a reduced risk of cardiovascular disease (CVD). The metabolic and functional consequences of lower-limb paralysis, including the gain in relative adiposity and physical inactivity, result in a high prevalence of CVD in individuals with a spinal cord injury (SCI). However, the magnitude of any contraction-induced myokine response in this population may be limited by the small active muscle mass of the upper-limb. The combination of voluntary, upper-limb exercise and involuntary, functional electrical stimulation (FES)-evoked lower-limb cycling termed ‘hybrid’ exercise, may augment the acute myokine response by activating a greater volume of muscle mass than upper-limb exercise alone. Five community-based individuals with motor complete, thoracic SCI (Age=44±15 years; Body mass=66.6±14.3 kg) and at least 3 months FES-evoked cycling experience volunteered to participate. On separate occasions, each participant performed 30 min of voluntary upper-limb, hand cycling exercise with (HYBRID) and without (ARM only) the addition of FES-evoked lower-limb cycling at a fixed workload. Blood samples were collected at rest, immediately post-exercise, and 1 and 2 h post-exercise. Plasma concentrations of IL-6, IL-10 and IL-1ra were subsequently determined by enzyme linked immunoassay. Estimated energy expenditure was significantly higher in HYBRID (154±25 kcal) than ARM (132±21 kcal) (P=0.01; ES=0.90). Plasma IL-6 concentrations were significantly elevated following HYBRID, with values 1 h and 2 h post-exercise significantly higher than rest and immediately post-exercise (P\u3c0.04). A small (~50%) non-significant increase in IL-6 was present 1 h and 2 h post-exercise following ARM, however concentrations were significantly higher in HYBRID than ARM at the same time points (P\u3c0.02). Plasma IL-10 concentrations were unaffected by exercise in ARM. Although not attaining statistical significance, there was a tendency for IL-10 concentrations to rise in HYBRID, with an 85% increase in IL-10 concentrations at 2 h post exercise. Plasma IL-1ra was unaffected by exercise in both trials. Initial findings suggest paralysed skeletal muscle releases the myokine IL-6 in response to electrically evoked contractions. Further, voluntary upper-limb exercise combined with involuntary lower-limb FES-evoked exercise had the tendency to elevate plasma concentrations of the anti-inflammatory cytokine IL-10; this effect was not present when performing arm exercise alone. Hybrid exercise may offer a method of maximising the anti-inflammatory potential of acute exercise in individuals with a SCI. The current findings require verification in a larger cohort