Who Are User Entrepreneurs? Findings on Innovation, Founder Characteristics, and Firm Characteristics

Documents the prevalence of innovators who create products or services for their own use then start firms, by industry and type. Examines founder and firm characteristics, revenue growth, job creation, R&D investment, and intellectual property creation

The Arts, Loose Parts and Conversations

Educators today are being asked to design curricula whereby learners’ abilities to analyze, question, problem-solve, evaluate and reflect are being provoked. The quest lies in uncovering suitable teaching approaches that will allow critical thinking skills to emerge organically and meaningfully. I argue that an integration of loose parts can offer a methodology and a provocation that makes way for open-ended, divergent and creative thinking skills to be activated. “Loose parts” can be open-ended materials that are manipulated, designed, dismantled and reconstructed in multiple ways. I also see “loose parts” as a mindset, a process-oriented approach whereby meaningful conversations emerge unexpectedly and add significantly to learning. This article presents two stories to show how arts-based approaches and mindfulness to loose parts can unearth thought-filled and caring conversations. The discussion is inspired and written via a reflective lens of personal encounters, first, in a longitudinal research project with young children in an Indigenous First Nations Community, and, second, with preservice teachers in a university class. It is within these periods that students, teachers and families were impacted by loose parts whereby materials and conversations made way for new perspectives in understanding the world

Towards Developing a Cost-Benefit Model for Learning Management Systems

Although Learning Management Systems (LMS) have become a common place in higher education many stakeholders invest in this technology once the expected benefits align with the strategic goals of the institution and the technology falls within a given budget. However, it is not immediately apparent how stakeholders can determine whether the level of investment associated with implementing the LMS is justified by the benefits obtained. In this paper, a case study will be used to identify the costs and benefits associated with the implementation of a web-based LMS. In the instances where these costs and benefits and indirect, measures will be proposed that can be used to quantify them. The goal is to produce information that stakeholders can use to understand the value of their investments and at the same time, practitioners can use the information to maximize the value of the investment in a LMS

An evaluation of a school-based group treatment programme for children of divorce

This study outlines and evaluates a school-based group intervention programme, offering support and teaching problem-solving skills, for children of divorce. The effect of the programme on children's beliefs about divorce and their self-concept is empirically investigated. A sample of 17 latency age children was divided into an experimental group and a wait-list condition control group. The results indicate that a group intervention programme can contribute towards positive changes in children's beliefs about divorce and improvements in their self-concept. Treatment effects for children of divorce are not only associated with the fonnal group intervention programme. Children in both groups improved on several measures from first to second testing and several explanations are offered for these findings. This study suggests that group interventions can contribute to improved adjustment outcomes for children of divorce, by helping children develop more realistic beliefs about divorce and by improving their self-conceptSocial WorkM.A. (Social Science) in Mental Healt

Gender Differences in Fear and Risk Perception During the Covid-19 Pandemic

The COVID-19 pandemic has led many people to suffer from emotional distress. Previous studies suggest that women process and express affective experiences, such as fear, with a greater intensity compared to men. We administered an online survey to a sample of participants in the United States that measures fear of COVID-19, perceptions about health and financial risks, and preventative measures taken. Despite the empirical fact that men are more likely to experience adverse health consequences from COVID-19, women report greater fear and more negative expectations about health-related consequences of COVID-19 than men. However, women are more optimistic than men regarding the financial consequences of the pandemic. Women also report more negative emotional experiences generally during the pandemic, particularly in situations where other people or the government take actions that make matters worse. Though women report taking more preventative measures than men in response to the pandemic, gender differences in behavior are reduced after controlling for fear. These results shed light on how differences in emotional experiences of the pandemic may inform policy interventions

IVF, acupuncture and mental health : a qualitative study of perceptions and experiences of women participating in a randomized controlled trial of acupuncture during IVF treatment

Infertility treatments such as in-vitro fertilization (IVF) are stressful and challenging to mental health and well-being. The use of alternative therapies adjunct to IVF treatment, such as acupuncture, is common and women hope to improve their chance of pregnancy and live birth. While many women engage in acupuncture adjunct to IVF in Australia, few qualitative studies of women’s motivations and experiences have been conducted in this field. A qualitative study was nested within a randomized controlled trial of acupuncture during IVF treatment in order to explore women’s perceptions of acupuncture, its effects in the context of IVF treatment, and how acupuncture is perceived in relation to the outcome of IVF. Fifty women randomized into both acupuncture and sham acupuncture groups were interviewed using a semi-structured format. In-depth interviews were transcribed, coded and categorized in a theoretical thematic analysis. Two primary themes emerged: ‘psychological benefit’ and ‘perceived influence of acupuncture on fertility/medical outcome’. Regardless of randomization, women in both groups described similar psychological effects suggesting that a placebo effect was present. They were not convinced that acupuncture could enhance their treatment outcome through biomedical pathways. Rather, they perceived that acupuncture or sham acupuncture gave them a psychological advantage through increased relaxation, reduced psychological stress, and enhanced wellbeing and self-efficacy. In conclusion, there are significant features associated with a placebo effect in acupuncture that might be exploited to provide psychological benefit for women undertaking IVF

Quality of Life is Similar between Long-term Survivors of Indolent and Aggressive Non-Hodgkin Lymphoma

Differences in quality of life (QOL) of long-term survivors of aggressive or indolent subtypes of non-Hodgkin lymphoma (NHL) have not been frequently evaluated. We assessed these differences by analyzing results of a large QOL survey of long-term NHL survivors. We hypothesized that the incurable nature of indolent NHL would relate to worse QOL in long-term survivors while the potentially cured long-term survivors of aggressive lymphoma would have better QOL. We found that QOL was similar between the two groups. Results suggest that patients with indolent NHL are coping well with their disease, yet experience some overall feelings of life threat

Screening for Elder Mistreatment among Older Adults Seeking Legal Assistance Services

Introduction: The aging population is a rapidly growing demographic in the United States. Isolation, limited autonomy, and declining physical and mental health render many older adults vulnerable to elder mistreatment (EM). The purpose of this study was to assess the prevalence and correlates of EM among a sample of older adults using legal assistance services in Atlanta, Georgia. Methods: Researchers administered surveys to consenting older adults (aged 60þ) in 5 metro Atlanta community centers that hosted legal assistance information sessions as part of the Elderly Legal Assistance Program. The surveys screened for risk factors and prevalence of EM risk using valid and reliable measures and included additional questions regarding demographics characteristics and healthcare use behaviors. Results: Surveys were completed by 112 participants. Findings reveal that 32 (28.6%) respondents met the criteria for elder abuse / neglect risk; 17 (15.2%) respondents met criteria for depression; and 105 (93.7%) had visited a healthcare provider during the past 6 months. Conclusion: The rates of EM risk in this sample were higher than those previously reported in research. Findings support continued examination of unique risks that may be present among older adults who may be possibly facing legal issues. Additionally, the reported frequency of healthcare visits among participants reveals a promising opportunity to examine development of a more widespread EM screening approach to be conducted in non-emergency settings. Interdisciplinary collaboration is required to inform screening approaches that account for complexities that EM cases present. [West J Emerg Med. 2013;14(4):309–315.] INTRODUCTIO

Clostridium difficile and methicillin-resistant Staphylococcus aureus shedding by slaughter-age pigs

<p>Abstract</p> <p>Background</p> <p><it>Clostridium difficile </it>and methicillin-resistant <it>Staphylococcus aureus </it>are critical human pathogens and of increasing concern in food animals. Because of the apparent impact of age on prevalence of these organisms, studies of slaughter age pigs are important when considering the potential for contamination of food. This study evaluated <it>C. difficile </it>and MRSA shedding by slaughter age pigs from farms across Canada.</p> <p>Results</p> <p><it>Clostridium difficile </it>was isolated from 30/436 (6.9%) samples from 15/45 (33%) farms. After adjusting for clustering at the herd level, the prevalence was 3.4%. Ribotype 078 (toxinotype V, North American Pulsotype 7) was the most common strain, accounting for 67% of isolates. MRSA was isolated from 21/460 (4.6%) pigs from 5/46 (11%) farms. The prevalence in pigs after adjusting for clustering at the herd level was 0.2%. Seven different spa types were identified, with 3 related spa types (t011, t034, new) accounting for 16 (76%) consistent with ST398 predominating.</p> <p>Both MRSA and <it>C. difficile </it>samples were collected from 45 farms. Both MRSA and <it>C. difficile </it>were detected on 2 (4.4%), with <it>C. difficile </it>only on 13 (29%), MRSA only on 3 (6.7%) and neither on 27 (60%).</p> <p>Conclusions</p> <p>The prevalence of <it>C. difficile </it>and MRSA in slaughter age pigs was relatively low, particularly in comparison with studies involving younger pigs. The predominance of <it>C. difficile </it>ribotype 078 and MRSA ST398 was not surprising, but there was diversity in strain types and the majority of isolates of both organisms were strains that can be found in humans. While the prevalence of <it>C. difficile </it>and MRSA in slaughter age pigs was relatively low, there is clearly potential for contamination of meat from healthy pigs carrying this pathogen into slaughterhouses.</p

Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors

Apoptosis plays an essential role during brain development, yet the precise mechanism by which this pathway is regulated in the brain remains unknown. In particular, mammalian cells are known to express multiple anti-apoptotic Bcl-2 family proteins. However, the cells of the developing brain could also exist in a primed state in which the loss of a single anti-apoptotic Bcl-2 family protein is sufficient to trigger apoptosis. Here, we examined the critical role of Bcl-xL, an anti-apoptotic protein, during brain development. Using conditional knock-out mice in which Bcl-xL is deleted in neural progenitor cells (Bcl-xLEmx1–Cre), we show that the loss of Bcl-xL is not sufficient to trigger apoptosis in these proliferating progenitors. In contrast, specific populations of postmitotic neurons derived from these progenitors, including upper layer cortical neurons and the CA1–CA3 regions of the hippocampus, were acutely dependent on Bcl-xL. Consistent with this finding, deletion of Bcl-xL selectively in the postmitotic neurons in the brain (Bcl-xLNex–Cre) also resulted in similar patterns of apoptosis. This Bcl-xL deficiency-induced neuronal death was a consequence of activation of the apoptotic pathway, because the cell death was rescued with codeletion of the proapoptotic proteins Bax and Bak. Importantly, the loss of these Bcl-xL-dependent neurons led to severe neurobehavioral abnormalities, including deficits in motor learning, hyperactivity, and increased risk-taking and self-injurious behaviors. Together, our results identify a population of neurons in the developing brain that are acutely dependent on Bcl-xL during the peak period of synaptic connectivity that are important for the establishment of higher-order complex behaviors