1,160 research outputs found

    Defining common criteria for harmonizing life cycle assessments of livestock systems

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    Animal production intensification puts pressure on resources, leads to environmental impacts, animal welfare and biodiversity issues. Livestock products provide key components of the human diet and contribute to rural territories through ecosystem services such as nutrient and biomass recycling. Life cycle assessment (LCA) is key to assess environmental impacts in livestock systems and products. A harmonization of LCA methods is necessary to improve evaluations in these areas as LCA still lacks accuracy and robustness in addressing sustainability across livestock systems and products. Here, a participatory harmonization approach was applied to provide a framework to evaluate LCAs of current and future livestock systems. A total of 29 workshops with targeted discussions among 21 LCA experts were organised, together with two anonymous surveys to harmonise evaluation criteria. First, key research topics for improving LCAs of livestock systems were identified as follows: i) Food, feed, fuel and biomaterial competition, crop-livestock interaction and the circular economy; ii) Biodiversity; iii) Animal welfare; iv) Nutrition; v) GHG emissions. Next, general evaluation criteria were identified for livestock focussed LCA methods, considering livestock systems characteristics: Transparency and Reproducibility, Completeness, Fairness and Acceptance, Robustness and Accuracy. Evaluation criteria specific to each key topic were also identified. This participatory method was successful in narrowing down general and specific evaluation criteria through targeted discussion. Moreover, this study provided a holistic participatory framework for the evaluation of LCA methods addressing the impacts of livestock systems across a range of key topics which can be further used for other sectors

    Learning from innovative practitioners: Evidence for the sustainability and resilience of pasture fed livestock systems

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    There is an urgent need for transformational change in agriculture to address current and future issues caused by climate change, biodiversity loss and socio-ecological disruption. But change is slow to come and is hindered by a lack of transdisciplinary evidence on potential approaches which take a systems approach. The research described here was co-developed with the Pasture Fed Livestock Association in the UK to objectively evidence their practices. These include producing pasture-based meat from livestock fed on pasture and pasture-based forages alone. This approach sits alongside wider aims of fitting their practices with the ecological conditions on each individual farm to facilitate optimal production and working collaboratively through a forum for sharing knowledge. The research provides strong indications that the PFLA approach to livestock production is resilient and viable, as well as contributing to wider public goods delivery, despite variability within and between farms. It also reveals that learning and adaption of practice (through farmer experience) is central to farming using agro-ecological approaches. This fluidity of practice presents challenges for reductionist approaches to "measuring" agricultural innovations

    Inverse dynamics modelling of upper-limb tremor, with cross-correlation analysis

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    A method to characterise upper-limb tremor using inverse dynamics modelling in combination with cross-correlation analyses is presented. A 15 degree-of-freedom inverse dynamics model is used to estimate the joint torques required to produce the measured limb motion, given a set of estimated inertial properties for the body segments. The magnitudes of the estimated torques are useful when assessing patients or evaluating possible intervention methods. The cross-correlation of the estimated joint torques is proposed to gain insight into how tremor in one limb segment interacts with tremor in another. The method is demonstrated using data from a single patient presenting intention tremor because of multiple sclerosis. It is shown that the inertial properties of the body segments can be estimated with sufficient accuracy using only the patient's height and weight as a priori knowledge, which ensures the method's practicality and transferability to clinical use. By providing a more detailed, objective characterisation of patient-specific tremor properties, the method is expected to improve the selection, design and assessment of treatment options on an individual basis

    A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus

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    The innate immune system is critical in the response to infection by pathogens and it is activated by pattern recognition receptors (PRRs) binding to pathogen associated molecular patterns (PAMPs). During viral infection, the direct recognition of the viral nucleic acids, such as the genomes of DNA viruses, is very important for activation of innate immunity. Recently, DNA-dependent protein kinase (DNA-PK), a heterotrimeric complex consisting of the Ku70/Ku80 heterodimer and the catalytic subunit DNA-PKcs was identified as a cytoplasmic PRR for DNA that is important for the innate immune response to intracellular DNA and DNA virus infection. Here we show that vaccinia virus (VACV) has evolved to inhibit this function of DNA-PK by expression of a highly conserved protein called C16, which was known to contribute to virulence but by an unknown mechanism. Data presented show that C16 binds directly to the Ku heterodimer and thereby inhibits the innate immune response to DNA in fibroblasts, characterised by the decreased production of cytokines and chemokines. Mechanistically, C16 acts by blocking DNA-PK binding to DNA, which correlates with reduced DNA-PK-dependent DNA sensing. The C-terminal region of C16 is sufficient for binding Ku and this activity is conserved in the variola virus (VARV) orthologue of C16. In contrast, deletion of 5 amino acids in this domain is enough to knockout this function from the attenuated vaccine strain modified vaccinia virus Ankara (MVA). In vivo a VACV mutant lacking C16 induced higher levels of cytokines and chemokines early after infection compared to control viruses, confirming the role of this virulence factor in attenuating the innate immune response. Overall this study describes the inhibition of DNA-PK-dependent DNA sensing by a poxvirus protein, adding to the evidence that DNA-PK is a critical component of innate immunity to DNA viruses

    Bridging Alone: Religious Conservatism, Marital Homogamy, and Voluntary Association Membership

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    This study characterizes social insularity of religiously conservative American married couples by examining patterns of voluntary associationmembership. Constructing a dataset of 3938 marital dyads from the second wave of the National Survey of Families and Households, the author investigates whether conservative religious homogamy encourages membership in religious voluntary groups and discourages membership in secular voluntary groups. Results indicate that couples’ shared affiliation with conservative denominations, paired with beliefs in biblical authority and inerrancy, increases the likelihood of religious group membership for husbands and wives and reduces the likelihood of secular group membership for wives, but not for husbands. The social insularity of conservative religious groups appears to be reinforced by homogamy—particularly by wives who share faith with husbands
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