Addiction: Physiology in Performance, Opioid Pharmacology in Character Development for the Theater

Actors inquire into the physical, mental, and emotional impulses of their respective characters in the effort to develop a cohesive persona for the stage. The goal of this research is to determine whether a more thorough, scientific understanding of the physiopyschological phenomena a character experiences, specifically opioid withdrawal, will aid in the depiction of symptoms on stage. The project began with a research period and culminated in physical dissemination through theater performance. Both video, audio, and text media were utilized to establish a thorough comprehension of the physiological mechanisms in opioid addiction. Further profiling of the characteristics and symptomatic episodes of addicted persons were emphasized in the research period to be implemented and represented in rehearsal. The rehearsal process was comprised of three-four hours of rehearsal for seven weeks and included both individual character work with the director as well as scene work with fellow actors. Six shows in total were performed in the Barnelle Theater and research was found to be particularly applicable in Act 1, Scene 2 of the show. Physical symptoms of withdrawal, such as hot and cold sweats, muscular cramping, shaking, and physical anxiety, were mimicked and integrated into performance to convey opioid dependence. It was determined that understanding the science behind the symptoms allowed for a more realistic depiction of addiction in performance. Further research should include in-person testimony and interviews from individuals who have experienced substance abuse, withdrawal, and addiction

The Impact of Tree Species, Elevated Nitrogen Deposition, Stand Age, and Environmental Factors on Herbaceous Plant Communities in a Central Appalachian Hardwood Forest

Although the herb layer represents less than 1% of the biomass of temperate forests, this layer may contain up to 90% of the plant species in the forest and can contribute up to 20% of the foliar litter, thus playing an essential role in forest biodiversity and nutrient cycling. The objectives of this study were to investigate the differences in cover, species richness, Shannon-Wiener diversity, and evenness of herb layer plants a) under tree species associated with contrasting soil nitrogen levels and b) in watersheds that vary in nitrogen deposition, stand age, and watershed aspect at the Fernow Experimental Forest in West Virginia. In the watersheds evaluated, overstory tree species, N deposition level, stand age, and other environmental factors influenced herb layer characteristics. This study demonstrated 1) a sugar maple effect, i.e. sugar maple having a positive effect on understory cover, at intermediate levels of soil fertility in reference watersheds and in an N-fertilized watershed by improving the nutrient microenvironment for herb layer plants, 2) that long-term N enrichment can reduce ecosystem biodiversity by favoring nitrophilic species, and 3) that herb layer characteristics can be influenced by stand age, with more recent disturbance being reflected in higher herb layer abundance and diversity. This study justifies further examination of tree-herb layer interactions for a wider range of tree species, N-deposition levels, and stand ages in future studies in order to inform adaptive forest management in the light of climate change and other continuing anthropogenic influences

Connecting Cluster Substructure in Galaxy Cluster Cores at z=0.2 With Cluster Assembly Histories

We use semi-analytic models of structure formation to interpret gravitational lensing measurements of substructure in galaxy cluster cores (R<=250kpc/h) at z=0.2. The dynamic range of the lensing-based substructure fraction measurements is well matched to the theoretical predictions, both spanning f_sub~0.05-0.65. The structure formation model predicts that f_sub is correlated with cluster assembly history. We use simple fitting formulae to parameterize the predicted correlations: Delta_90 = tau_90 + alpha_90 * log(f_sub) and Delta_50 = tau_50 + alpha_50 * log(f_sub), where Delta_90 and Delta_50 are the predicted lookback times from z=0.2 to when each theoretical cluster had acquired 90% and 50% respectively of the mass it had at z=0.2. The best-fit parameter values are: alpha_90 = (-1.34+/-0.79)Gyr, tau_90 = (0.31+/-0.56)Gyr and alpha_50 = (-2.77+/-1.66)Gyr, tau_50 = (0.99+/-1.18)Gyr. Therefore (i) observed clusters with f_sub<~0.1 (e.g. A383, A1835) are interpreted, on average, to have formed at z>~0.8 and to have suffered <=10% mass growth since z~0.4, (ii) observed clusters with f_sub>~0.4 (e.g. A68, A773) are interpreted as, on average, forming since z~0.4 and suffering >10% mass growth in the ~500Myr preceding z=0.2, i.e. since z=0.25. In summary, observational measurements of f_sub can be combined with structure formation models to estimate the age and assembly history of observed clusters. The ability to ``age-date'' approximately clusters in this way has numerous applications to the large clusters samples that are becoming available.Comment: Accepted by ApJL, 4 pages, 2 figure

Who goes where? The importance of peer groups on attainment and the student use of the lecture theatre teaching space

Understanding how students interact and learn within the lecture theatre environment is central to successful learning outcomes. Previous studies into the use of the lecture theatre teaching space have found that students sit in specific locations due to a range of factors; these include being noticed, addressing anxiety or an ability to focus. This study further explores the personal and social factors at play within students’ lecture theatre seating choice and the resulting effects on attainment. Student responses on seating preferences detailing why they chose a given location were mapped at a seat‐specific level and correlated against attainment. In parallel, staff perceptions of student attainment in relation to their seating choice were obtained. No direct correlation between student location and attainment was found, contrary to staff perceptions. Interestingly, it was found that students physically locate into friendship groups clusters and that these clusters obtained similar levels of attainment in problem‐solving tasks, with pockets of both high‐ and low‐performing students being observed. It was also noted that isolated students performed less well. These data would indicate that peer group formation exerts a strong impact on attainment and engagement. Outcomes from this study will enable academic staff to better understand the student body and inform the way in which teaching sessions are performed within a lecture theatre

Transfer of autocollimator calibration for use with scanning gantry profilometers for accurate determination of surface slope and curvature of state of the art x ray mirrors

X ray optics, desired for beamlines at free electron laser and diffraction limited storage ring x ray light sources, must have almost perfect surfaces, capable of delivering light to experiments without significant degradation of brightness and coherence. To accurately characterize such optics at an optical metrology lab, two basic types of surface slope profilometers are used the long trace profilers LTPs and nanometer optical measuring NOM like angular deflectometers, based on electronic autocollimator AC ELCOMAT 3000. The inherent systematic errors of the instrument s optical sensors set the principle limit to their measuring performance. Where autocollimator of a NOM like profiler may be calibrated at a unique dedicated facility, this is for a particular configuration of distance, aperture size, and angular range that does not always match the exact use in a scanning measurement with the profiler. Here we discuss the developed methodology, experimental set up, and numerical methods of transferring the calibration of one reference AC to the scanning AC of the Optical Surface Measuring System OSMS , recently brought to operation at the ALS Xray Optics Laboratory. We show that precision calibration of the OSMS performed in three steps, allows us to provide high confidence and accuracy low spatial frequency metrology and not print into measurements the inherent systematic error of tool in use. With the examples of the OSMS measurements with a state of the art x ray aspherical mirror, available from one of the most advanced vendors of X ray optics, we demonstrate the high efficacy of the developed calibration procedure. The results of our work are important for obtaining high reliability data, needed for sophisticated numerical simulations of beamline performance and optimization of beamline usage of the optics. This work was supported by the U. S. Department of Energy under contract number DE AC02 05CH1123

Road safety education for older drivers : evaluation of a classroom-based training initiative

Around the world, a growing proportion of drivers are aged 70 or over. Although accident rates for older drivers are lower than for young or novice drivers, increased frailty and slowed reactions mean that older drivers are at higher risk of death or serious injury when involved in a road collision. The objectives of this study were to: (a) identify driving knowledge and self-regulatory strategies among a group of older drivers with a view to planning future on-road training; (b) measure driver self-assessments of ability and confidence before and after classroom training delivered by driving instructors; (c) evaluate the utility and acceptability of training courses for older drivers using questionnaires and focus groups; d) examine the characteristics of course participants. 142 drivers aged ≥75 completed a two-hour classroom-based driving course and took part in the evaluation: 94 aged 75–79, 48 aged ≥80, 68% male. Main reasons for taking part were to update knowledge, improve driving and check they were safe to drive. Results showed that females were more likely than males to avoid driving in difficult conditions (at night, in bad weather, unfamiliar roads). More drivers aged 75–79 said they did not restrict their driving (52, 57%) compared to drivers aged ≥80 (19, 43%). Pre-course, males rated their driving confidence and ability significantly higher than females. Post-course, self-ratings of confidence and ability were unchanged for 76 (60%) drivers. However, two-thirds reported improved knowledge and 80% said they would change their driving behaviour as a result of the course. Focus group results suggest that competent drivers are more likely to attend educational courses than unsafe drivers. This study provides preliminary evidence that classroom-based training can initiate behaviour change among older drivers. Future research will examine the effectiveness of on-road training in this age group

tmRNA - a novel high-copy-number RNA diagnostic target - its application for Staphylococcus aureus detection using real-time NASBA

A real-time nucleic acid sequence-based amplification assay, targeting tmRNA, was designed for the rapid identification of Staphylococcus aureus. The selectivity of the assay was confirmed against a panel of 76 Staphylococcus strains and species and 22 other bacterial species. A detection limit of 1 cell equivalent was determined for the assay. A chimeric in vitro transcribed internal amplification control was developed and included in the assay. Application of the assay in natural and artificially contaminated unpasteurized (raw) milk enabled detection of 1-10 CFUS. aureus mL(-1) in 3-4 h, without the need for culture enrichment. Staphylococcus aureus was detected in all artificially contaminated milk samples (n=20) and none of the natural milk samples (n=20). Microbiological analysis of the natural milk samples was performed in parallel according to ISO 6888-3 and confirmed the absence of S. aureus. The method developed in this study has the potential to enable the specific detection of S. aureus in raw milk in a significantly shorter time frame than current standard methods. The assay further demonstrates the usefulness of tmRNA/ssrA as a nucleic acid diagnostic target

Human Decompression Modelling

At present, no decompression algorithm is able to predict safe decompression for all dive scenarios. In practice, empirical adjustments are made by experienced organisations or divers in order to improve decompression profiles for the range of depths and durations needed on any particular dive. Bubble formation and growth in the human body are the fundamental causes of decompression sickness, and it is believed that there is significant scope for incorporating better modelling of these processes into the design of decompression algorithms. VR Technology is a leading supplier of technical dive computers. The company is interested in expanding upon an existing algorithm (the Variable Gradient Model - VGM), which is used to design ascent profiles/decompression schedules and thereby mitigate the risk of decompression sickness in divers. The Study Group took the approach of trying to extend the existing Haldane model to account more explicitly for the formation of bubbles. By extending the model to include bubble dynamics it was expected that some physical understanding could be gained for the existing modifications to some of the parameters. The modelling that occurred consisted of first looking at the Haldane model and then considering a single small isolated bubble in each of the compartments and interpreting the predictions of the model in terms of decompression profiles

IVF, acupuncture and mental health : a qualitative study of perceptions and experiences of women participating in a randomized controlled trial of acupuncture during IVF treatment

Infertility treatments such as in-vitro fertilization (IVF) are stressful and challenging to mental health and well-being. The use of alternative therapies adjunct to IVF treatment, such as acupuncture, is common and women hope to improve their chance of pregnancy and live birth. While many women engage in acupuncture adjunct to IVF in Australia, few qualitative studies of women’s motivations and experiences have been conducted in this field. A qualitative study was nested within a randomized controlled trial of acupuncture during IVF treatment in order to explore women’s perceptions of acupuncture, its effects in the context of IVF treatment, and how acupuncture is perceived in relation to the outcome of IVF. Fifty women randomized into both acupuncture and sham acupuncture groups were interviewed using a semi-structured format. In-depth interviews were transcribed, coded and categorized in a theoretical thematic analysis. Two primary themes emerged: ‘psychological benefit’ and ‘perceived influence of acupuncture on fertility/medical outcome’. Regardless of randomization, women in both groups described similar psychological effects suggesting that a placebo effect was present. They were not convinced that acupuncture could enhance their treatment outcome through biomedical pathways. Rather, they perceived that acupuncture or sham acupuncture gave them a psychological advantage through increased relaxation, reduced psychological stress, and enhanced wellbeing and self-efficacy. In conclusion, there are significant features associated with a placebo effect in acupuncture that might be exploited to provide psychological benefit for women undertaking IVF