Source parameters of the 28 October 1983 Borah Peak, Idaho, earthquake from body wave analysis

Modeling of long-period body waves of the M_S = 7.3 Borah Peak, Idaho, earthquake suggests that the earthquake was a simple rupture that nucleated at a depth of about 16 km and propagated unilaterally northwestward toward the surface. The seismic moment tensor obtained from the inversion of teleseismic body wave amplitude data agrees well with the fault plane solution obtained from short-period first motion data (strike, 138 ± 3°; dip, 45 ± 3°; rake, −60 ± 5°) and the observed surface faulting. The scalar double couple moment of 2.1 × 10^(26) dyne-cm obtained from the inversion is comparable to a moment of 1.4 × 10^(26) dyne-cm estimated from the observed surface faulting. Estimates of stress drop based on these values for the moment are 17 to 12 bars, respectively

Origin of Hawaiian Tholeiites: Trace Element Constraints

We report here geochemical studies of Hawaiian tholeiites and ultramafic xenoliths from Salt Lake Crater, Oahu. We focus attention on tholeiitic basalts that comprise the bulk of Hawaiian volcanoes. When the samples are screened to include only those lying neat the log-MgO (about 7 percent) end of olivine-control lines (Wright, 1971), tholeiites from individual volcanoes are remarkably uniform. On this basis, we show that, for tholeiites from six volcanoes, systematic geochemical differences exist that cannot be attributed to differentiation of these magmas from a common parental magma. Apparently there have been important differences in the processes of magma generation, source composition, or source mineral constitution. Partial melting calculations based on REE contents emphasize these distinctions, but unique melting models are not presented. In these models, relative REE abundances in the source material is a major uncertainty. Nd isotopic studies of Hawaiian basalts require systematic differences in Sm/Nd for the source material of each volcano. Furthermore, the time-integrated Sm/Nd of the sources must be less than that in chondrites. REE analyses of Hawaiian garnet lherzolite xenoliths show that they have chondritic to light REE-enriched relative abundances with absolute contents (for light REE) about 3 to 8 times chondrites. These data obviously conflict with interpretations of the Nd isotopic data. Several possibilities follow: (1) the available xenoliths are not parental to tholeiite, (2) our simple interpretation of the Nd isotopic data is wrong, and (3) the source regions may have been invaded at geologically recent times by a light REE-enriched phase, in which case the xenoliths may represent the course material. If the xenoliths are characteristic of the source, partial melting calculations indicate that the tholeiites may be generated by 15 to 20 percent melting of garnet lherzolite and at the sane tune conform to constraints imposed by the REE and Ni contents and the partitioning of Fe and Mg between melts and residues. We propose that the primary tholeiitic magmas contain no more than about 12 percent MgO, and that erupted magmas probably fractionated less than 10 to 15 percent of olivine during ascent and storage in high-level chambers

Data Management Tools to Measure the Impact of Core Facilities

The Biomolecular Research Center at Boise State University is a research core facility that supports the study of biomolecules with an emphasis on protein structure and function, molecular interactions, and imaging. The mission of the core is to facilitate access to instrumentation that might otherwise be unavailable because of the cost, training for new users, and scientific staff with specialized skills to support early-stage investigators, as well as more established senior investigators. Data collection and management of users and their research output is essential to understand the impact of the center on the research environment and research productivity. However, challenges are often encountered when trying to fully quantify the impact of a core facility on the institution, as well as on the career success of individual investigators. This challenge can be exacerbated under the conditions of unprecedented growth in biomedical research and shared core facility use that has been experienced at Boise State University, an institution of emerging research excellence. Responding to these challenges required new approaches to information management, reporting, assessment, and evaluation. Our specific data management, evaluation, and assessment challenges included 1) collection and management of annual reporting information from investigators, staff, and students in a streamlined manner that did not lead to reporting fatigue; 2) application of software for analyzing synergy among programs’ management strategy and investigator success; and 3) consolidation of core facility management, billing, and reporting capabilities into 1 cohesive system. The data management tools adopted had a beneficial effect by saving time, reducing administrative burden, and streamlining reporting. Practices implemented for data management have facilitated effective evaluation and future program planning. The substantial burden of assessment requirements necessitates early consideration of a strategy for data management to allow assessment of impact

Searching for Planets in the Hyades. I. The Keck Radial Velocity Survey

We describe a high-precision radial velocity search for jovian-mass companions to main sequence stars in the Hyades star cluster. The Hyades provides an extremely well controlled sample of stars of the same age, the same metallicity, and a common birth and early dynamical environment. This sample allows us to explore the dependence of the process of planet formation on only a single independent variable: the stellar mass. In this paper we describe the survey and summarize results for the first five years.Comment: 8 pages, 3 figures; To appear in the July 2002 issue of The Astronomical Journa

Petrology and geochemistry of late-stage intrusions of the A-type, mid-Proterozoic Pikes Peak batholith (Central Colorado, USA): implications for petrogenetic models

The ~1.08 Ga anorogenic, A-type Pikes Peak batholith (Front Range, central Colorado) is dominated by coarse-grained, biotite ± amphibole syenogranites and minor monzogranites, collectively referred to as Pikes Peak granite (PPG). The batholith is also host to numerous small, late-stage plutons that have been subdivided into two groups (e.g. Wobus, 1976. Studies in Colorado Field Geology, Colorado School of Mines Professional Contributions, Colorado): (1) a sodic series (SiO2 = ~44–78 wt%; K/Na = 0.32–1.36) composed of gabbro, diabase, syenite/quartz syenite and fayalite and sodic amphibole granite; and (2) a potassic series (SiO2 = ~70–77 wt%; K/Na = 0.95–2.05), composed of biotite granite and minor quartz monzonite. Differences in major and trace element and Nd isotopic characteristics for the two series indicate different petrogenetic histories. Potassic granites of the late-stage intrusions appear to represent crustal anatectic melts derived from tonalite sources, based on comparison of their major element compositions with experimental melt products. In addition, Nd isotopic characteristics of the potassic granites [εNd (1.08 Ga) = −0.2 to −2.7] overlap with those for tonalites/granodiorites [ca 1.7 Ga Boulder Creek intrusions; εNd (1.08 Ga) = −2.4 to −3.6] exposed in the region. Some of the partial melts evolved by fractionation dominated by feldspar. The late-stage potassic granites share geochemical characteristics with most of the PPG, which is also interpreted to have an anatectic origin involving tonalitic crust. The origin of monzogranites associated with the PPG remains unclear, but mixing between granitic and mafic or intermediate magmas is a possibility. Syenites and granites of the sodic series cannot be explained as crustal melts, but are interpreted as fractionation products of mantle-derived mafic magmas with minor crustal input. High temperature and low oxygen fugacity estimates (e.g. Frost et al., 1988. American Mineralogist 73, 727–740) support a basalt fractionation origin, as do εNd values for sodic granitoids [εNd (1.08 Ga) = +2.2 to −0.7], which are higher than εNd values for Colorado crust at 1.08 Ga (ca −1.0 to −4.0). Enrichments in incompatible elements (e.g. rare earth elements, Rb, Y) and depletions in compatible elements (e.g. Cr, Sr, Ba) in the sodic granitoids compared to coeval mafic rocks are also consistent with fractionation. Accessory mineral fractionation, release of fluorine-rich volatiles and/or removal of pegmatitic fluids could have modified abundances of Ce, Nb, Zr and Y in some sodic granitoid magmas. Gabbros and mafic dikes associated with the sodic granitoids have εNd (1.08 Ga) of −3.0 to +3.5, which are lower than depleted mantle at 1.08 Ga, and their trace element characteristics suggest derivation from mantle sources that were previously affected by subduction-related processes. However, it is difficult to characterize the mantle component in these magmas, because assimilation of crust during magma ascent could also result in their observed geochemical features. The Pikes Peak batholith is composed of at least two petrogenetically different granite types, both of which exhibit geochemical characteristics typical of A-type granites. Models proposed for the petrogenesis of the granitoids imply the existence of mafic rocks at depth and addition of juvenile material to the crust in central Colorado at ~1.1 Ga

Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production

Male development, fertility, and lifelong health are all androgen-dependent. Approximately 95% of circulating testosterone is synthesized by the testis and the final step in this canonical pathway is controlled by the activity of the hydroxysteroid-dehydrogenase-17-beta-3 (HSD17B3). To determine the role of HSD17B3 in testosterone production and androgenization during male development and function we have characterized a mouse model lacking HSD17B3. The data reveal that developmental masculinization and fertility are normal in mutant males. Ablation of HSD17B3 inhibits hyperstimulation of testosterone production by hCG, although basal testosterone levels are maintained despite the absence of HSD17B3. Reintroduction of HSD17B3 via gene-delivery to Sertoli cells in adulthood partially rescues the adult phenotype, showing that, as in development, different cell-types in the testis are able to work together to produce testosterone. Together, these data show that HS17B3 acts as a rate-limiting-step for the maximum level of testosterone production by the testis but does not control basal testosterone production. Measurement of other enzymes able to convert androstenedione to testosterone identifies HSD17B12 as a candidate enzyme capable of driving basal testosterone production in the testis. Together, these findings expand our understanding of testosterone production in males

Scaffold-free bioprinting of mesenchymal stem cells using the Regenova printer: Spheroid characterization and osteogenic differentiation

Limitations in scaffold material properties, such as sub-optimal degradation time, highlight the need for alternative approaches to engineer de novo tissues. One emerging solution for fabricating tissue constructs is scaffold-free tissue engineering. To facilitate this approach, three-dimensional (3D) bioprinting technology (Regenova Bio 3D Printer) has been developed to construct complex geometric shapes from discrete cellular spheroids without exogenous scaffolds. Optimizing spheroid fabrication and characterizing cellular behavior in the spheroid environment are important first steps prior to printing larger constructs. Here, we characterized spheroids of immortalized mouse bone marrow stromal cells (BMSCs) that were differentiated to the osteogenic lineage. Immortalized BMSCs were seeded in low attachment 96-well plates in various numbers to generate self-aggregated spheroids either under the force of gravity or centrifugation. Cells were cultured in control or osteogenic media for up to 28 days. Spheroid diameter, roundness and smoothness were measured. Cell viability, DNA content and alkaline phosphatase activity were assessed at multiple time points. Additionally, expression of osteogenic markers was determined using real time qPCR. Spheroids formed under gravity with 20 K, 30 K and 40 K cells had average diameters of 498.5 ± 8.3 μm, 580.0 ± 32.9 μm and 639.2 ± 54.0 μm, respectively, while those formed under 300G centrifugation with the same numbers of cells had average diameters of 362.3 ± 3.5 μm, 433.1 ± 6.4 μm and 491.2 ± 8.0 μm. Spheroids formed via centrifugation were superior to those formed by gravity, as evidenced by better roundness and smoothness and double the retention of DNA (cellular) content. Cells in spheroids exhibited a robust osteogenic response to the differentiation medium, including higher mRNA expression of alkaline phosphatase, collagen type I, and osteocalcin than those cultured in control medium, as well as greater alkaline phosphatase activity. The optimal spheroid fabrication technique from this study was to aggregate 40 K cells under 150–300G centrifugation. In future investigations, these spheroids will be 3D printed into larger tissue constructs

Relationship of transcriptional markers to Leydig cell number in the mouse testis

ObjectivesThe current study aims to identify markers that would reflect the number of Leydig cells present in the testis, to help determine whether labour-intensive methods such as stereology are necessary. We used our well-characterised Sertoli cell ablation model in which we have empirically established the size of the Leydig cell population, to try to identify transcriptional biomarkers indicative of population size.ResultsFollowing characterisation of the Leydig cell population after Sertoli cell ablation in neonatal life or adulthood, we identified Hsd3b1 transcript levels as a potential indicator of Leydig cell number with utility for informing decision-making on whether to engage in time-consuming stereological cell counting analysis

Recycling bins, garbage cans or think tanks? Three myths regarding policy analysis institutes

The phrase 'think tank' has become ubiquitous – overworked and underspecified – in the political lexicon. It is entrenched in scholarly discussions of public policy as well as in the 'policy wonk' of journalists, lobbyists and spin-doctors. This does not mean that there is an agreed definition of think tank or consensual understanding of their roles and functions. Nevertheless, the majority of organizations with this label undertake policy research of some kind. The idea of think tanks as a research communication 'bridge' presupposes that there are discernible boundaries between (social) science and policy. This paper will investigate some of these boundaries. The frontiers are not only organizational and legal; they also exist in how the 'public interest' is conceived by these bodies and their financiers. Moreover, the social interactions and exchanges involved in 'bridging', themselves muddy the conception of 'boundary', allowing for analysis to go beyond the dualism imposed in seeing science on one side of the bridge, and the state on the other, to address the complex relations between experts and public policy