Incorporation of Functionalized Polyhedral Oligomeric Silsesquioxane Nanomaterials as Reinforcing Agents for Impact Ice Mitigating Coatings

In-flight, aircraft are exposed to a wide range of environments. One commonly exposed environment are clouds containing super-cooled water droplets. These water drop- lets exist in a metastable state below the freezing point of water, in the range of 0 to -20C. As the vehicle impacts the droplets, latent heat is released and within milliseconds the droplets convert to ice. This process is referred to as impact icing or in-flight icing.1 Impact icing is a major concern for aircraft since it can lead to degraded aerodynamic performance and, if left un- treated, can lead to loss of the vehicle. Active approaches (i.e., pneumatic boots, heated air ducts) typically utilized in mitigating in-flight ice accretion significantly increases vehicle weight and cannot be applied to all aircraft.1-3 A passive approach based on coatings is desired, but durability issues are a concern, especially on the wing leading edge.3 Nanomaterials have been shown to afford significant improvement in coating and composite physical properties at low loading levels.4 In this study, Polyhedral Oligomeric Silsesquioxane (POSS) nanomaterials have been shown to increase coating durability. Also, with wide variety of functionalities present on the arm structure, POSS nanomaterials have been shown to readily alter coating surface chemistry to mitigate impact ice adhesion from -16 to -8C in a simulated in-flight icing environment

Elastic response of a nematic liquid crystal to an immersed nanowire

We study the immersion of a ferromagnetic nanowire within a nematic liquid crystal using a lattice Boltzmann algorithm to solve the full three-dimensional equations of hydrodynamics. We present an algorithm for including a moving boundary, to simulate a nanowire, in a lattice Boltzmann simulation. The nematic imposes a torque on a wire that increases linearly with the angle between the wire and the equilibrium direction of the director field. By rotation of these nanowires, one can determine the elastic constants of the nematic.Comment: 10 pages, 8 figure

Modification of Projected Velocity Power Spectra by Density Inhomogeneities in Compressible Supersonic Turbulence

(Modified) The scaling of velocity fluctuation, dv, as a function of spatial scale L in molecular clouds can be measured from size-linewidth relations, principal component analysis, or line centroid variation. Differing values of the power law index of the scaling relation dv = L^(g3D) in 3D are given by these different methods: the first two give g3D=0.5, while line centroid analysis gives g3D=0. This discrepancy has previously not been fully appreciated, as the variation of projected velocity line centroid fluctuations (dv_{lc} = L^(g2D)) is indeed described, in 2D, by g2D=0.5. However, if projection smoothing is accounted for, this implies that g3D=0. We suggest that a resolution of this discrepancy can be achieved by accounting for the effect of density inhomogeneity on the observed g2D obtained from velocity line centroid analysis. Numerical simulations of compressible turbulence are used to show that the effect of density inhomogeneity statistically reverses the effect of projection smoothing in the case of driven turbulence so that velocity line centroid analysis does indeed predict that g2D=g3D=0.5. Using our numerical results we can restore consistency between line centroid analysis, principal component analysis and size-linewidth relations, and we derive g3D=0.5, corresponding to shock-dominated (Burgers) turbulence. We find that this consistency requires that molecular clouds are continually driven on large scales or are only recently formed.Comment: 28 pages total, 20 figures, accepted for publication in Ap

Self-incentives uniquely boost cessation in community-based stop smoking programs: Randomized controlled trial

Background: Self-incentives offer a plausible alternative to paying smokers to quit but have not yet been tested in a randomized controlled trial.  Purpose: The present study tested whether, compared with a control group, prompting smokers explicitly to self-incentivize if they abstain from smoking for a week or a month encouraged sustained abstinence.  Method: One hundred and fifty-nine smokers were recruited from stop smoking clinics and randomized to an active control condition (asked to form a plan to quit, n = 65) or one of two intervention conditions in which they were asked to form implementation intentions designed to ensure that they incentivized themselves if they had not smoked at all by the end of (a) the week (n = 44) or (b) the month (n = 50). The main outcome measure was self-reported abstinence at 3- and 6-month follow-ups, which was biochemically verified at baseline and in a subsample at 3-month follow-up.  Results: At 3-month follow-up, 34% (15/44; p < .05, d = 0.45) and 36% (18/50; p < .05, d = 0.49) of smokers abstained in the weekly and monthly self-incentivizing conditions respectively, compared with 15% (10/65) in the control. The same pattern of findings was observed at 6-month follow-up: 30% (13/44; p < .05, d = 0.35), 34% (17/50; p < .05, d = 0.45) and 15% (10/65) of smokers remained abstinent in the two intervention groups and control group, respectively.  Conclusions: Ensuring that smokers self-incentivized boosted significantly the effectiveness of the stop smoking program. Self-incentivizing implementation intentions could be implemented at low cost with high public health “reach” to change many health behaviors beyond smoking

CMV-Specific CD8 T Cell Differentiation and Localization: Implications for Adoptive Therapies.

Human cytomegalovirus (HCMV) is a ubiquitous virus that causes chronic infection and, thus, is one of the most common infectious complications of immune suppression. Adoptive transfer of HCMV-specific T cells has emerged as an effective method to reduce the risk for HCMV infection and/or reactivation by restoring immunity in transplant recipients. However, the CMV-specific CD8(+) T cell response is comprised of a heterogenous mixture of subsets with distinct functions and localization, and it is not clear if current adoptive immunotherapy protocols can reconstitute the full spectrum of CD8(+) T cell immunity. The aim of this review is to briefly summarize the role of these T cell subsets in CMV immunity and to describe how current adoptive immunotherapy practices might affect their reconstitution in patients. The bulk of the CMV-specific CD8(+) T cell population is made up of terminally differentiated effector T cells with immediate effector function and a short life span. Self-renewing memory T cells within the CMV-specific population retain the capacity to expand and differentiate upon challenge and are important for the long-term persistence of the CD8(+) T cell response. Finally, mucosal organs, which are frequent sites of CMV reactivation, are primarily inhabited by tissue-resident memory T cells, which do not recirculate. Future work on adoptive transfer strategies may need to focus on striking a balance between the formation of these subsets to ensure the development of long lasting and protective immune responses that can access the organs affected by CMV disease

Young Clusters in the Nuclear Starburst of M 83

We present a photometric catalog of 45 massive star clusters in the nuclear starburst of M 83 (NGC 5236), observed with the Hubble Space Telescope WFPC2, in both broad-band (F300W, F547M, and F814W) and narrow-band (F656N and F487N) filters. By comparing the photometry to theoretical population synthesis models, we estimate the age and mass of each cluster. We find that over 75% of the star clusters more massive than 2*10^4 Msun in the central 300 pc of M 83 are less than 10 Myr old. Among the clusters younger than 10 Myr and more massive than 5*10^3 Msun, 70% are between 5 and 7 Myr old. We list an additional 330 clusters that are detected in our F300W images, but not in the shallower F547M and F814W images. The clusters are distributed throughout a semicircular annulus that identifies the active region in the galaxy core, between 50 and 130 pc from the optical center of M 83. Clusters younger than 5 Myr are preferentially found along the perimeter of the semicircular annulus. We suggest that the 5-7 Myr population has evacuated much of the interstellar material from the active ringlet region, and that star formation is continuing along the edges of the region.Comment: 40 pages, 13 figures, accepted to ApJ

The Effect of Stainless Steel 304 Surface Roughness on Ice Adhesion Shear Strength of Accreted Impact Ice

Aircraft in-flight icing is problematic due to the ad-verse effect on vehicle performance. It occurs when supercooled water droplets (SCWD) present in clouds, under the appropriate environmental conditions, col-lide with the aircraft surface resulting in accretion of ice (i.e., impact icing). Impact ice can range from clear/glaze to rime or a combination of the two (i.e., mixed) with the type determined by the air temperature (0 to -20C), liquid water content (LWC, 0.3-0.6 g/cu.m), and droplet size [median volumetric diameter (MVD) of 15-40 m] present during accretion.1 These impact icing events generally occur at temperatures ranging from 0 to -20C. Below -20C, ice crystals dominate the environment and typically do not adhere to the aircraft surface. A main difference between an impact icing occurrence and a slow growth icing (i.e., freezer ice) one is the speed of the icing event. Besides environmental conditions, ice adhesion strength (IAS) to a metallic substrate depends upon surface roughness. It is known that increasing surface roughness and decreasing temperature lead to in-creases in IAS

Waveguide Photonic Microstructures in III-V Semiconductors

Photonic microstructures are a class of periodic dielectric structures which could lead to a significant evolution in optoelectronic devices. There are, however, several problems with photonic crystals, not least of which is the fabrication of these artificial structures. The fabrication of these artificial crystals in III-V semiconductor materials, specifically optical waveguide heterostructures, have been investigated. Improvements in the fabrication of GaAs/AlGaAs photonic bandgap structures have been made and the development of an AlAs epitaxial layer as a pattern transfer mask has been demonstrated. Two-dimensional photonic bandgap structures have been characterised and good agreement has been obtained between theory and experimental measurements. Subsequently, semiconductor microcavities incorporating photonic bandgap mirrors have been fabricated with mirror reflectivities higher than 90% and high mode Q factors, Q&ap;500. The results indicate that photonic bandgap technology has the potential to provide the desired engineering of the environment of a light emitter which will allow control of the emission process. The microstructuring of the material, however, creates significant obstacles to electroluminescence and much research in this area is required if any benefit of photonic microstructures are to be seen

The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis infection. [preprint]

Protection from infectious disease relies on two distinct mechanisms. \u27Antimicrobial resistance\u27 directly inhibits pathogen growth, whereas \u27infection tolerance\u27 controls tissue damage. A single immune-mediator can differentially contribute to these mechanisms in distinct contexts, confounding our understanding of protection to different pathogens. For example, the NADPH-dependent phagocyte oxidase complex (Phox) produces anti-microbial superoxides and protects from tuberculosis in humans. However, Phox-deficient mice do not display the expected defect in resistance to M. tuberculosis leaving the role of this complex unclear. We re-examined the mechanisms by which Phox contributes to protection from TB and found that mice lacking the Cybb subunit of Phox suffered from a specific defect in tolerance, which was due to unregulated Caspase1 activation, IL-1β production, and neutrophil influx into the lung. These studies demonstrate that Phox-derived superoxide protect against TB by promoting tolerance to persistent infection, and highlight a central role for Caspase1 in regulating TB disease progression