The validity of thoracolumbar injury classification and biomechanical approach in the clinical outcome of operative and non-operative treatments

In the United States, the incidence of thoracolumbar injures is approximately 15,000 per year due to highenergy trauma resulting mainly from a motor vehicle accident in younger patients. Most commonly, thoracolumbar (TL) injuries occur at the T10 to L2 level, which is the most common site afflicted by trauma. Numerous classification systems for thoracolumbar spine injuries have established. Currently, there is no universal acceptance of a classification system for thoracolumbar spine injuries that facilitates proper communication between treating physicians and helps to standardize approaches to treatment

Atypical pulmonary presentation of strongyloides stercoralis hyperinfection in a patient with Philadelphia chromosome-positive acute lympoblastic leukemia

Strongyloides stercoralis is a soil-transmitted helminth endemic to tropical and subtropical regions. Rhabditiform larvae in moist soil can develop into filariform larvae that can penetrate human skin and migrate through the circulation to the lungs.1,2 These larvae escape to the alveolar space and migrate to the pharynx. Larvae can settle in the small intestine and mature into adults afterbeing swallowed in pharyngeal secretion. In immunocompromised patients, the parasite can cause autoinfection with progression to hyperinfection syndrome. We present a case of Strongyloides stercoralis hyperinfection in a patient who is immunosuppressed secondary to hyper-CVAD chemotherapy regimen for Ph+ ALL

Effects of oral-contraceptive use on aerobic performance In active college aged women

Clinical Scenario: The growing number of 18-25 year old female athletes utilizing oral contraceptive pills (OCP) calls for further investigation of how these hormonal changes may impact performance. College age women taking oral contraceptives may participate in exercise or organized sport requiring peak physical and cognitive performance. Thus, in order to prevent injury, research as to how OCP affect performance is necessary.Clinical Question: Does the use of OCP reduce aerobic performance in physically active collegeage females compared to eumenorrheic women of similar performance level?Summary of Key Findings: Two of the four included studies reported that aerobic performance was decreased in those taking OCP, while the other two demonstrated no significant difference.Clinical Bottom Line: No conclusions can be made at this time as to whether OCP use reduces aerobic performance in college aged physically active women. Further research with larger cohorts is necessary to form a consensus.Strength of Recommendation: Grade B evidence suggests more research is needed to determine if OCP use reduces aerobic performance in active college age females compared to eumenorrheic women

Effectiveness of whole-body vibration on improving balance in athletes with chronic ankle instability

Context: Chronic ankle instability is a condition that can occur after multiple ankle injuries, or one severe ankle injury, and can affect balance, proprioception and walking mechanics. Improving balance can be helpful in rehabilitating those with chronic ankle instability. Whole body vibration treatment (WBV), vibration delivered at a specific amplitude and frequency through a platform that the patient is standing on, has been used to help increase neuromuscular control and proprioception in lower extremity injury rehabilitation but very little is known about WBV’s effect on balance. Balance in athletes with CAI has been seen to improve with balance training but there is little research on the effects of using WBV in this population.Clinical Question: Does Whole-Body Vibration treatment effectively improve balance in athletes with Chronic ankle Instability more than balance training?Summary of Key Findings: The following data bases were used to search terms of Chronic Ankle Instability (CAI), whole body vibration treatment (WBV), CAI and Athlete, CAI and WBV (PubMed, EBSCOHost, and SPORTSDiscus.) Only peer-reviewed studies that were randomized control trials that were published within the last 5 years were included. Of the two studies included, both found that whole body vibration treatment did not improve balance when compared to balance programs.Clinical Bottom Line: There is moderate evidence that indicates that WBV does help improve balance but does not improve balance more than a balance training in athletes with CAI. While recent, there is limited research on this topic at this time.Strength of recommendation:

Tumor microenvironment in pancreatic ductal adenocarcinoma: Implications in immunotherapy

Pancreatic ductal adenocarcinoma is one of the most aggressive and lethal cancers. Surgical resection is the only curable treatment option, but it is available for only a small fraction of patients at the time of diagnosis. With current therapeutic regimens, the average 5-year survival rate is less than 10% in pancreatic cancer patients. Immunotherapy has emerged as one of the most promising treatment options for multiple solid tumors of advanced stage. However, its clinical efficacy is suboptimal in most clinical trials on pancreatic cancer. Current studies have suggested that the tumor microenvironment is likely the underlying barrier affecting immunotherapy drug efficacy in pancreatic cancer. In this review, we discuss the role of the tumor microenvironment in pancreatic cancer and the latest advances in immunotherapy on pancreatic cancer

The Office

This newsletter was created by the Fall 2016 Honors English Class from Stephen F. Austin State University. Throughout the semester students were asked to define and interpret the terms work and labor. Through our individual research on different aspects of work and labor, we hope to expand the general spectrum of what encompasses these topics. Works and labor are two important aspects of our culture. They are umbrella terms that encompass many occupational fields and serve as a uniting factor in modern-day society. Aspects of work and labor are observable in an assortment of environments, whether it be through schoolwork as children or salary-paying jobs as adults. Because the global employment industry as a whole has such strong relations to work and labor ingrained in how duties are completed, there is a wide range of areas where they are applicable. Here, in this newsletter, many different aspects of these terms will be discussed. There are more elements to work and labor than many realize. Through the works included in our newsletter, we hope to expand the general understanding of work, labor, and the components that make them what they are

The Grizzly, September 14, 2006

Activities Fair Held at Ursinus • Employment at Ursinus • Frustration with Changes • New Exhibit Opens at the Berman • Career Services Offers Help for Seniors • A Look at the Upcoming Theater Season • Spotlight on New Faculty: Dr. Jonathan Marks • Steering Clear of a Sperm Shortage • 2006 MTV Video Music Awards • Trappe Historical Society Presents Program About Historic Route 113 • Opinions: Gays in the Scouts; Be Wary of Your Wording: Response to the UC Republicans • Spoiled Start • Women\u27s Soccer a Contender • Men\u27s Soccer Ties #14 Salisbury • Bears Tame Lions in Road Openerhttps://digitalcommons.ursinus.edu/grizzlynews/1717/thumbnail.jp

Wastewater Surveillance for SARS-CoV-2 on College Campuses: Initial Efforts, Lessons Learned, and Research Needs

Wastewater surveillance for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging approach to help identify the risk of a coronavirus disease (COVID-19) outbreak. This tool can contribute to public health surveillance at both community (wastewater treatment system) and institutional (e.g., colleges, prisons, and nursing homes) scales. This paper explores the successes, challenges, and lessons learned from initial wastewater surveillance efforts at colleges and university systems to inform future research, development and implementation. We present the experiences of 25 college and university systems in the United States that monitored campus wastewater for SARS-CoV-2 during the fall 2020 academic period. We describe the broad range of approaches, findings, resources, and impacts from these initial efforts. These institutions range in size, social and political geographies, and include both public and private institutions. Our analysis suggests that wastewater monitoring at colleges requires consideration of local information needs, sewage infrastructure, resources for sampling and analysis, college and community dynamics, approaches to interpretation and communication of results, and follow-up actions. Most colleges reported that a learning process of experimentation, evaluation, and adaptation was key to progress. This process requires ongoing collaboration among diverse stakeholders including decision-makers, researchers, faculty, facilities staff, students, and community members

Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa

Three lineages (BA.1, BA.2 and BA.3) of the SARS-CoV-2 Omicron variant of concern predominantly drove South Africa's fourth COVID-19 wave. We have now identified two new lineages, BA.4 and BA.5, responsible for a fifth wave of infections. The spike proteins of BA.4 and BA.5 are identical, and comparable to BA.2 except for the addition of 69-70del (present in the Alpha variant and the BA.1 lineage), L452R (present in the Delta variant), F486V and the wild type amino acid at Q493.The two lineages only differ outside of the spike region. The 69-70 deletion in spike allows these lineages to be identified by the proxy marker of S-gene target failure, on the background of variants not possessing this feature . BA.4 and BA.5 have rapidly replaced BA.2, reaching more than 50% of sequenced cases in South Africa by the first week of April 2022. Using a multinomial logistic regression model, we estimate growth advantages for BA.4 and BA.5 of 0.08 (95% CI: 0.08 - 0.09) and 0.10 (95% CI: 0.09 - 0.11) per day respectively over BA.2 in South Africa. The continued discovery of genetically diverse Omicron lineages points to the hypothesis that a discrete reservoir, such as human chronic infections and/or animal hosts, is potentially contributing to further evolution and dispersal of the virus

2015 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1002/thumbnail.jp