Resolved Imaging of the HD191089 Debris Disc

Two thirds of the F star members of the 12 Myr old Beta Pictoris Moving Group (BPMG) show significant excess emission in the mid-infrared, several million years after the expected dispersal of the protoplanetary disc. Theoretical models of planet formation suggest that this peak in the mid-infrared emission could be due to the formation of Pluto-sized bodies in the disc, which ignite the collisional cascade and enhance the production of small dust. Here we present resolved mid-infrared imaging of the disc of HD191089 (F5V in the BPMG) and consider its implications for the state of planet formation in this system. HD191089 was observed at 18.3 microns using T-ReCS on Gemini South and the images were compared to models of the disc to constrain the radial distribution of the dust. The emission observed at 18.3 microns is shown to be significantly extended beyond the PSF at a position angle of 80 degrees. This is the first time dust emission has been resolved around HD191089. Modelling indicates that the emission arises from a dust belt from 28-90 AU, inclined at 35 degrees from edge on with very little emission from the inner 28AU of the disc, indicating the presence of an inner cavity. The steep slope of the inner edge is more consistent with truncation by a planet than with ongoing stirring. A tentative brightness asymmetry F(W)/F(E)=0.80+/-0.12 (1.8 sigma) between the two sides of the disc could be evidence for perturbations from a massive body on an eccentric orbit in the system.Comment: 11 Pages Accepted to MNRA

Combating Stress & Promoting Wellness at UC\u27s College of Law

Lawyers are stressed out, and so are law students. For decades, we have been saying that law students arrive at law school with the same level of mental wellness as the general population, but by the time they graduate from law school, law students have surpassed the general population in depression, anxiety and stress. To counteract this trend at the University of Cincinnati (UC) College of Law, we offer an extra-curriculum mind-body class

It\u27s About Time: Examining the Role of Time Together and Perceived Stress in Couple Relationships

Because stress is a common struggle in romantic relationships and because stress can spill over into couples’ interactions and affect their level of relationship connection, it is important to understand what can help couples adapt to stress and maintain meaningful relationships. Quality time together has been found to have positive effects on relationship outcomes overall. Additionally, family stress theory has posited that having sufficient resources can help couples adapt to stress and avoid a crisis situation. As such, time together was examined as a potential resource for couples to draw upon to adapt to the potential negative effects of perceived stress on relationship connectivity. This study utilized information from 615 individuals living in the United States and Canada to understand if time together acted as a resource that could buffer the negative effects of perceived stress. Findings showed that for those in the study, time together could act as a potential buffering resource to perceived stress. Those who spent more time together were also more resilient to perceived stress. The results suggest that professionals working with couples could help them discover ways they can invest meaningful, quality time together on a regular basis

Zipline-Related Injuries Treated in US EDs, 1997-2012

Purpose To investigate the epidemiology of zipline-related injuries in the United States. Basic Procedures The National Electronic Injury Surveillance System database was used to examine non-fatal zipline-related injuries treated in US emergency departments (EDs) from 1997 through 2012. Sample weights were applied to calculate national estimates. Main Findings From 1997 through 2012, an estimated 16850 (95% CI, 13188-20512) zipline-related injuries were treated in US EDs. The annual injury rate per 1 million population increased by 52.3% from 7.64 (95% CI, 4.86-10.42) injuries in 2009 (the first year with a stable annual estimate) to 11.64 (95% CI, 7.83-15.45) injuries in 2012. Patients aged 0-9 years accounted for 45.0% of injuries, females made up 53.1% of injuries, and 11.7% of patients required hospitalization. Fractures accounted for the largest proportion of injuries (46.7%), and the upper extremities were the most commonly injured body region (44.1%). Falls were the most common mechanism of injury, accounting for 77.3% of injuries. Among cases where the location of the injury event was known, 30.8% of injuries occurred in a residential setting and 69.2% occurred in a public place. Principal Conclusions This study is the first to characterize the epidemiology of zipline-related injuries using a nationally representative database. The rapid increase in zipline-related injuries in recent years suggests the need for additional safety guidelines and regulations. Commercial ziplines and publicly accessible non-commercial ziplines should be subject to uniform safety standards in all states and jurisdictions across the US, and homemade ziplines should not be used

New graduate registered nurses in public health

This presentation investigates the following objectives: 1) to discuss current challenges facing the public health nursing profession; 2) to synthesize existing literature regarding new graduate registered nurses (RNs) in public health; 3) to present the benefits of hiring new graduate RNs with baccalaureate degrees into public health agencies; 4) to utilize existing literature to suggest support measures that will optimize new graduate RNs’ success in public health

Analysis of Toxic Amyloid Fibril Interactions at Natively Derived Membranes by Ellipsometry

There is an ongoing debate regarding the culprits of cytotoxicity associated with amyloid disorders. Although small pre-fibrillar amyloid oligomers have been implicated as the primary toxic species, the fibrillar amyloid material itself can also induce cytotoxicity. To investigate membrane disruption and cytotoxic effects associated with intact and fragmented fibrils, the novel in situ spectroscopic technique of Total Internal Reflection Ellipsometry (TIRE) was used. Fibril lipid interactions were monitored using natively derived whole cell membranes as a model of the in vivo environment. We show that fragmented fibrils have an increased ability to disrupt these natively derived membranes by causing a loss of material from the deposited surface when compared with unfragmented fibrils. This effect was corroborated by observations of membrane disruption in live cells, and by dye release assay using synthetic liposomes. Through these studies we demonstrate the use of TIRE for the analysis of protein-lipid interactions on natively derived lipid surfaces, and provide an explanation on how amyloid fibrils can cause a toxic gain of function, while entangled amyloid plaques exert minimal biological activity

Individual differences in infant fixation duration relate to attention and behavioral control in childhood

Individual differences in fixation duration are considered a reliable measure of attentional control in adults. However, the degree to which individual differences in fixation duration in infancy (0–12 months) relate to temperament and behavior in childhood is largely unknown. In the present study, data were examined from 120 infants (mean age = 7.69 months, SD = 1.90) who previously participated in an eye-tracking study. At follow-up, parents completed age-appropriate questionnaires about their child’s temperament and behavior (mean age of children = 41.59 months, SD = 9.83). Mean fixation duration in infancy was positively associated with effortful control (β = 0.20, R2 = .02, p = .04) and negatively with surgency (β = −0.37, R2 = .07, p = .003) and hyperactivity-inattention (β = −0.35, R2 = .06, p = .005) in childhood. These findings suggest that individual differences in mean fixation duration in infancy are linked to attentional and behavioral control in childhood

A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels

DNA looping by two-site restriction endonucleases: heterogeneous probability distributions for loop size and unbinding force

Proteins interacting at multiple sites on DNA via looping play an important role in many fundamental biochemical processes. Restriction endonucleases that must bind at two recognition sites for efficient activity are a useful model system for studying such interactions. Here we used single DNA manipulation to study sixteen known or suspected two-site endonucleases. In eleven cases (BpmI, BsgI, BspMI, Cfr10I, Eco57I, EcoRII, FokI, HpaII, NarI, Sau3AI and SgrAI) we found that substitution of Ca(2+) for Mg(2+) blocked cleavage and enabled us to observe stable DNA looping. Forced disruption of these loops allowed us to measure the frequency of looping and probability distributions for loop size and unbinding force for each enzyme. In four cases we observed bimodal unbinding force distributions, indicating conformational heterogeneity and/or complex binding energy landscapes. Measured unlooping events ranged in size from 7 to 7500 bp and the most probable size ranged from less than 75 bp to nearly 500 bp, depending on the enzyme. In most cases the size distributions were in much closer agreement with theoretical models that postulate sharp DNA kinking than with classical models of DNA elasticity. Our findings indicate that DNA looping is highly variable depending on the specific protein and does not depend solely on the mechanical properties of DNA