Protein Tyrosine Kinase Panel As a Tool for Anticancer Drug Design

The discovery of the pharmaceutical potential of small molecule inhibitors of oncogenic protein tyrosine kinases is one of the directions in target therapy in oncology. Presently, investigations aiming at developing new therapeutically important inhibitors have to be based on a combination of computational and experimental approaches including biochitalicical, cell-based or in silico screening and the study of the three-dimensional structure of the kinase active center, in complex with an inhibitor, using crystallography and X-ray analysis or molecular modeling. This work is an example of a combination of inhibitor experimental search with the computational analysis of the potential mechanism of the inhibitors' action, which allowed to propose the 2-hydroxyphenol group as a scaffold for the design of new tyrosine kinase inhibitors

Preparation and properties of hibryd organic-inorganic composites baced on poly-Ti02

Optically transparent hybrid organic-inorganic copolymers based on the poly- TiO2, vinyl monomers and lactide or glycolide have been prepared. Optical and physi- cal-mechanical properties of composites are depended with the ratio of components have shown. Hybrid copolymers possess photochromic properties. By the UV light excitation reversible darkening of the samples due to the transition Ti 4+ ļ Ti 3+ had observed. The speed of transition depends on the copolymer composition. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2059

Бесфиксационная герниопластика при грыжах передней брюшной стенки

Authors has developed algorithm of surgical treatment of the abdominal wall hernias, based on using the modern non-fixation mesh. This algorithm includes different surgical approaches (open and endoscopic) for inguinal and ventral hernias using polypropylene and polylactic acid mesh.В статье определено место бесфиксационных методик в лечении грыж передней брюшной стенки. Разработана целостная система оперативного лечения больных с грыжами передней брюшной стенки, на основе использования современных, не требующих фиксации имплантатов, которая может быть рекомендована к широкому внедрению

Study of T-odd Quark Fragmentation Function in Z0→2Z^0\to 2-jet Decay

The first probe of the correlation of the T-odd one-particle fragmentation function responsible for the left--right asymmetry of fragmentation of a transversely polarized quark and an antiquark is done by using the 1991-95 DELPHI data for $Z\to 2$ jet decay. Integrated over the fraction of longitudinal and transversal momenta, this correlation is of 2.5 ppm order, which means order of 7% for the analyzing power. This makes us hope to use certain effects in polarized DIS experiments for transversity measurement.Comment: 5 pages, 1 eps figure, latex, sprocl.sty and wrapfig.sty. Talk at 13 Int. Symp. on High Energy Spin Phys., submitted to Pro

Численное моделирование волн-убийц в океане

Modern approaches to studying of freak waves at ocean by means of computing experiments are consi-dered. The description of computing experimental installation is given, used numerical methods are described, and the review of the received results is given too.Рассматриваются современные подходы к изучению аномально больших поверхностных волн в океане, так называемых волн-убийц с помощью вычислительных экспериментов. Дано описание вычислительной экспериментальной установки, описаны численные используемые численные методы, приведён обзор полученных результатов

Method for replacing objects in 4F correlator: testing

The method of pattern recognition based on replacement of object images incoming to the correlator by object-dependent synthesized phase objects calculated using the iterative Fourier-transform algorithm was developed by us earlier. In this work, we performed experimental testing the above method by using an optical-digital 4F-correlator. Synthesized phase objects were inputed into the correlator through the spatial light modulator LC2002. Holographic matched filters were recorded using self-developing photopolymers PPC-488. For two test objects, we obtained unified (δ-like) correlation signals with the signal-to-noise ratio reaching 24 dB, while the diffraction efficiency of these filters was up to 30%

Диагностическое и прогностическое значения ядрышковых белков в регуляции пролиферации опухолевых клеток у больных с карциномой легких и адренокортикальным раком

We studied correlation between the degree of malignancy, prognosis, survival of oncological patients, and the number of proliferating cells (Ki-67 index), the rate of cell proliferation, the continuance of the mitotic cycle (and the expression of Ag-OYAOR-proteins-В23/nucleofozimine S23/nukleoline) in 16 patients with adrenocortical carcinoma and in 20 cases of “small” lung cancer (up to 3 cm in diameter), whose tumors were removed and long-term results were evaluated. The comparative study of proliferative activity of cells in the two groups of patients with different survival period after tumor removal showed the heterogeneity of Ki-67 index, which determined the number of proliferating cells. In the first group of patients (with a good prognosis) Ki-67 index was high, and expression of Ag-OYAOR proteins was low. At the same time, in the second group of patients, whose prognosis was poor, Ki-67 index in the tumor was low, but the expression of Ag-OYAOR-protein was high. So, we can make a conclusion, that it is impossible to discuss the degree of malignancy of the tumor and the prognosis, based only on Ki-67 index. Ag-OYAOR-protein and Ki-67 index reflect different aspects of cell proliferation: the rate of cell proliferation (Ag-OYAOR expression) and the number of proliferating cells (Ki-67 index).Изучены значения при определении степени злокачественности, прогноза, выживаемости онкологических больных, одновременного исследования количества пролиферирующих клеток (индекс Ki-67) и определения скорости клеточной пролиферации — длительности митотического цикла (экспрессия Ag-ОЯОР-белков — В23/нуклеофозмина и С23/нуклеолина) у 16 больных с адренокортикальной карциномой и 20 наблюдений так называемых «малых» раков легкого (до 3 см в диаметре), удаленных у пациентов с известными отдаленными результатами. Проведенное сравнительное исследование пролиферативной активности клеток в двух группах больных с различным сроком выживаемости после удаления опухоли показало неоднородность индекса Ki-67, определяющего количество пролиферирующих клеток. В первой группе (с благоприятным прогнозом) у части больных индекс Ki-67 в опухолях был высоким, а экспрессия Ag-ОЯОР-белков низкая. В то же время у ряда больных второй группы (с неблагоприятным прогнозом) индекс Ki-67 в опухоли был низким, но экспрессия Ag-ОЯОР-белков высокой. Следовательно исследование только индекса Ki-67 не всегда свидетельствует о степени злокачественности опухоли и прогнозе заболевания. Ag-ОЯОР-белки и индекс Ki-67 отражают разные аспекты пролиферативной активности клеток: скорость клеточной пролиферации (экспрессия Ag-ОЯОР) и количество пролиферирующих клеток (индекс Ki-67)