Drivers of Coral Reconstructed Salinity in the South China Sea and Maritime Continent: The Influence of the 1976 Indo-Pacific Climate Shift

The flow of Pacific water into the Indian Ocean via the South China Sea (SCS) and Maritime Continent (MC) plays an important role in the ocean thermohaline circulation providing the only low-latitude pathway for the inter-ocean exchange of heat and salt. The transport of the SCS and Indonesian throughflows is modulated by the East Asian monsoon and major climate modes associated with the Pacific and Indian Oceans. As an indicator of surface layer buoyancy, sea surface salinity (SSS) is critical to rates of exchange but instrumental records of SSS are short and sparse. Using empirical orthogonal functions, a synthesis of proxy-based reconstructions of SSS from coral δ18O is used to study the role of climate variability on long-term SSS behavior in the region. The leading mode of SSS variability in the boreal winter and summer responds to the influence of the 1976 Indo-Pacific climate shift. At multi-decadal timescales, only the East Asian monsoon and the Indian Ocean Dipole (IOD) retain their signal in winter and summer SSS after 1976. At higher frequencies, winter SSS shifts from having a strong East Asian monsoon signal to a more dominant impact of the IOD and the El Niño Southern Oscillation (ENSO) following the shift. In the summer, only a change in ENSO's influence on SSS variability is observed after 1976. The recent intensification and dominance of the IOD and ENSO in driving SSS variability in the SCS and MC may influence circulation in the regional throughflows and perhaps global thermohaline circulation

Coupled Model Biases Breed Spurious Low-Frequency Variability in the Tropical Pacific Ocean

Coupled general circulation model (GCM) biases in the tropical Pacific are substantial, including a westward extended cold sea surface temperature (SST) bias linked to El Niño–Southern Oscillation (ENSO). Investigation of internal climate variability at centennial timescales using multicentury control integrations of 27 GCMs suggests that a Pacific Centennial Oscillation emerges in GCMs with too strong ENSO variability in the equatorial Pacific, including westward extended SST variability. Using a stochastic model of climate variability (Hasselmann type), we diagnose such centennial SST variance in the western equatorial Pacific. The consistency of a simple stochastic model with complex GCMs suggests that a previously defined Pacific Centennial Oscillation may be driven by biases in high-frequency ENSO forcing in the western equatorial Pacific. A cautious evaluation of long-term trends in the tropical Pacific from GCMs is necessary because significant trends in historical and future simulations are possible consequences of biases in simulated internal variability alone

Coupled model biases breed spurious low-frequency variability in the tropical Pacific Ocean

Coupled general circulation model (GCM) biases in the tropical Pacific are substantial, including a westward extended cold sea surface temperature (SST) bias linked to El Niño–Southern Oscillation (ENSO). Investigation of internal climate variability at centennial timescales using multicentury control integrations of 27 GCMs suggests that a Pacific Centennial Oscillation emerges in GCMs with too strong ENSO variability in the equatorial Pacific, including westward extended SST variability. Using a stochastic model of climate variability (Hasselmann type), we diagnose such centennial SST variance in the western equatorial Pacific. The consistency of a simple stochastic model with complex GCMs suggests that a previously defined Pacific Centennial Oscillation may be driven by biases in high‐frequency ENSO forcing in the western equatorial Pacific. A cautious evaluation of long‐term trends in the tropical Pacific from GCMs is necessary because significant trends in historical and future simulations are possible consequences of biases in simulated internal variability alone.MOE (Min. of Education, S’pore)Published versio

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

A high-throughput screen against PknB, an essential serine–threonine protein kinase present in Mycobacterium tuberculosis (M. tuberculosis), allowed the identification of an aminoquinazoline inhibitor which was used as a starting point for SAR investigations. Although a significant improvement in enzyme affinity was achieved, the aminoquinazolines showed little or no cellular activity against M. tuberculosis. However, switching to an aminopyrimidine core scaffold and the introduction of a basic amine side chain afforded compounds with nanomolar enzyme binding affinity and micromolar minimum inhibitory concentrations against M. tuberculosis. Replacement of the pyrazole head group with pyridine then allowed equipotent compounds with improved selectivity against a human kinase panel to be obtained

Genomic reconstruction of the SARS-CoV-2 epidemic in England

AbstractThe evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021.</jats:p