Margaret Small Scrapbook - A2018-35-1

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Will Made Word and Other Conceptions

This thesis consists of a series of nine poems which deal with the theme of finding a balance between energy and form in life and in poetry. Fourteen miscellaneous poems are also included. In addition, an introduction by the author explains the purpose of the thesis as a whole and explicates the poems in terms of this purpose. The introduction discusses the meaning of each poem and the techniques used to convey its message. Each poem in the series of nine poems is also related to the. overall theme of the series

The Health of People with Intellectual Disability

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Identification of calcium-dependent phospholipid-binding proteins in higher plant cells

AbstractCalcium-dependent phospholipid-binding proteins of apparent Mr 33 000 and 35 000 were isolated from suspension cultures of tomato cells. Two-dimensional gel electrophoresis showed the proteins to have isoelectric points of approx. 5.7 and 5.6, respectively. In the presence of calcium, both proteins bound to liposomes formed from a mixture of phosphatidylserine and phosphatidylcholine, but not to liposomes of phosphatidylcholine alone. Both proteins showed immunological similarities to previously characterized calcium-dependent phospholipid-binding proteins (annexins) from Torpedo marmorata and mammalian species. The protein of Mr 33 000 cross-reacted with three separate antisera raised to the annexin Torpedo calelectrin, whereas that of Mr 35 000 cross-reacted with antisera to the bovine annexins p68 and p32/34. We suggest that the two proteins may represent the first identification in higher plants of the annexin family of calcium-dependent phospholipid-binding proteins

The Politics of Land Ownership in NSW: A Case Study

From 1885 to 1965, successive New South Wales governments made repeated attempts to break up large pastoral estates into family farms. This policy, which became known as closer settlement, was expected to address a range of pressing social and economic problems. This thesis takes a case study approach to assess the impact of this policy in a specific area, the county of Sandon on the NSW northern tablelands. It tests, at the local level, current theory and models of the land question, with the aim of furthering comprehension of this central issue in the development of New South Wales. From the passing of the Crown Lands Act 1884, the NSW government was increasingly intrusive in determining where land settlement should take place, who was permitted to acquire Crown land, and how large their farms should be. By the turn of the century, the attention of both the government and the community at large became focussed on the need to buy back land locked up in the large pastoral estates to create family farms for those who did not already own land. Under legislation passed from 1901 onwards, across the state many thousands of acres of freehold and leasehold land were compulsorily and voluntarily resumed for this purpose. In the county of Sandon, this resulted in some private subdivisions in response to the threat of compulsory resumption, a voluntary resumption in the late 1930s, and both voluntary and compulsory resumptions to provide farms for returned servicemen and women after the two world wars. The impact of closer settlement in the county of Sandon was marginal, in terms of the expected outcomes. A First World War soldier settlement at Kentucky in the south of the county resulted in an increase in the production of stone and pome fruit and a modest increase in population, with many of the soldier settlers being attracted from outside the district. A modest number of settlers came from outside the district to take farms created by the voluntary and compulsory resumptions in the late 1930s and following the Second World War, but otherwise there was no significant population increase. Over time successful farmers bought out their neighbours, and by 1965 most were engaged in the enterprise which had characterised the district in the first half of the nineteenth century, the grazing of sheep and cattle. Thus, there was no long-term change in agricultural output in the county. Based on this evidence, a new model of land settlement is proposed, that there are three forces which interact to determine the size of rural properties: ∙ Government policy which was aimed at creating family farms of what was known as ‘a home maintenance area’, that is, just large enough to support a family in average conditions, undertaking an enterprise best suited to their land; ∙ A tendency for more successful farmers to purchase additional land and so increase the size of their holdings, or to eventually provide farms for their children; and, ∙ A tendency for farms, over time, to either enlarge or contract to a size which is the most efficient. While it would seem that the first force would be the most powerful, since governments had the power to legislate a maximum farm size, the experience in the county of Sandon demonstrated that this was not the case, as there was a marked trend towards properties of an efficient size. Thus, this study has demonstrated that the policy of closer settlement had little impact on the pattern of land settlement

Building a STEM Mentoring Program in an Economically Disadvantaged Rural Community

Rural, economically disadvantaged communities face a bigger challenge than urban communities in recruiting and retaining high school (HS) students in science, technology, engineering, and mathematics (STEM) because many of these students do not have access to high-quality STEM opportunities. In this article, we describe a mentoring program we developed as part of a larger New York State education grant. This program was implemented in a rural community to connect undergraduate STEM students with HS students to increase HS students’ interest in these fields. In this program, HS students visited colleges, explored their interests in STEM, and learned about opportunities available to them in college and beyond. Here, we share the challenges and the successful strategies in implementing a mentoring program in a rural, economically disadvantaged region. The ideas described in the article were designed so other educators can gain insight on how to set up successful mentoring programs to attract and retain students in the STEM pipeline

Headspace analysis of mesothelioma cell lines differentiates biphasic and epithelioid sub-types.

Malignant mesothelioma (MM) is an incurable cancer. MM is often misdiagnosed, with a poor 5-year survival and limited treatment options. The discovery of endogenous volatile organic compounds (VOCs) is required in order to accelerate the development of a breath test as an alternative to conventional MM diagnosis. For the first time, this study used solid-phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS) to identify VOCs released directly from the biphasic MM cell line MSTO-211H and the epithelioid MM cell line NCI-H28 as well as the non-malignant mesothelial cell line MET-5A. Multivariate statistical analysis showed separation between MSTO-211H, NCI-H28 and MET-5A results. 2-ethyl-1-hexanol was significantly increased in both MSTO-211H and NCI-H28 cells compared to MET-5A controls. In addition, ethyl propionate and cyclohexanol were significantly increased in MSTO-211H cells and dodecane was significantly increased in NCI-H28 cells. This is the first study reporting headspace analysis of these MM cell lines and the first to consider the effects of mesothelioma sub-type on VOC profile. Current results further highlight the potential for a diagnostic mesothelioma breath test as well as providing proof of concept for the differentiation between biphasic and epithelioid mesothelioma based on VOC profiles

Referral Patterns Between Allopathic Physicians and Complementary and Alternative Medicine Practitioners: A Followup Study

Introduction: • Despite the high prevalence of Complementary and Alternative Medicine (CAM) usage, several recent surveys suggest that the vast majority of patient visits to CAM practitioners are self-referred and that communication between conventional and CAM practitioners is limited. • There is a need for a better understandingof factors influencing referral patterns across these two groups of practitioners. • Network analysis provides a useful tool to quantify relationships between members of an interrelated social network. • The goal of this follow up study was to quantify the cross-class referral patterns between conventional and CAM classes of practitioners in Chittenden County Vermont as well as gather additional information on the basis of referrals for future studies. • This study was a preliminary examination of possible reasons for the referral patterns.https://scholarworks.uvm.edu/comphp_gallery/1039/thumbnail.jp

Response Variability in Naming: A Computational Study

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Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer

Background Apalutamide, a competitive inhibitor of the androgen receptor, is under development for the treatment of prostate cancer. We evaluated the efficacy of apalutamide in men with nonmetastatic castration-resistant prostate cancer who were at high risk for the development of metastasis. Methods We conducted a double-blind, placebo-controlled, phase 3 trial involving men with nonmetastatic castration-resistant prostate cancer and a prostate-specific antigen doubling time of 10 months or less. Patients were randomly assigned, in a 2:1 ratio, to receive apalutamide (240 mg per day) or placebo. All the patients continued to receive androgen-deprivation therapy. The primary end point was metastasis-free survival, which was defined as the time from randomization to the first detection of distant metastasis on imaging or death. Results A total of 1207 men underwent randomization (806 to the apalutamide group and 401 to the placebo group). In the planned primary analysis, which was performed after 378 events had occurred, median metastasis-free survival was 40.5 months in the apalutamide group as compared with 16.2 months in the placebo group (hazard ratio for metastasis or death, 0.28; 95% confidence interval [CI], 0.23 to 0.35;