Artery Balloon Angioplasty and Depression Symptoms

Peripheral arterial occlusive disease (PAOD) as a chronic disease is associated with physical, psychological and social distress for elderly patients and their families. The study has three main aims: 1. to evaluate the occurrence and the relevance of depression symptoms in patients with PAOD, 2. to evaluate the effect of age and Fontaine stage of PAOD on relevance of depression in patients with PAOD, and 3. to evaluate the effect of artery balloon angioplasty (ABA)on occurence and relevance of depression symptoms. The study was prospective and longitudinal. Dates were obtained during year 2006. The total number of subjects with PAOD was 42 (28 males, 14 females). Thirty subjects with PAOD (20 male, 10 female) treated by ABA filled in Zung´s scale 3–6 months after ABA (61%). The mean age of all subjects was 65.4 years (aged 45–79). The evaluation of occurrence and relevance of depression was perfomed with Czech version of Zung self-rating depression scale (ZSRS). The mean Zung self-rating depression score (ZSRDS) certifies the presence of signs of minimum or mildly depression in patients with PAOD. The results proved statistically significant dependence of depression on age and on Fontaine stage of PAOD. Also, the results proved that artery balloon angioplasty has a highly positive effect on occurence and relevance of depression symptoms. The results had shown the existence of the association between PAOD, depression and ABA

Artery Balloon Angioplasty and Depression Symptoms

Peripheral arterial occlusive disease (PAOD) as a chronic disease is associated with physical, psychological and social distress for elderly patients and their families. The study has three main aims: 1. to evaluate the occurrence and the relevance of depression symptoms in patients with PAOD, 2. to evaluate the effect of age and Fontaine stage of PAOD on relevance of depression in patients with PAOD, and 3. to evaluate the effect of artery balloon angioplasty (ABA)on occurence and relevance of depression symptoms. The study was prospective and longitudinal. Dates were obtained during year 2006. The total number of subjects with PAOD was 42 (28 males, 14 females). Thirty subjects with PAOD (20 male, 10 female) treated by ABA filled in Zung´s scale 3–6 months after ABA (61%). The mean age of all subjects was 65.4 years (aged 45–79). The evaluation of occurrence and relevance of depression was perfomed with Czech version of Zung self-rating depression scale (ZSRS). The mean Zung self-rating depression score (ZSRDS) certifies the presence of signs of minimum or mildly depression in patients with PAOD. The results proved statistically significant dependence of depression on age and on Fontaine stage of PAOD. Also, the results proved that artery balloon angioplasty has a highly positive effect on occurence and relevance of depression symptoms. The results had shown the existence of the association between PAOD, depression and ABA

Quality of life in oncological and hematooncological patients after hematopoietic stem cell transplantation: The effect of selected psychosocial and health aspects on quality of life: A review of the literature

Haematopoietic stem cell transplantation is a therapeutic method which is not only used for the treatment of haematooncological diseases but also as a therapy for solid tumours and non-malignant diseases. Haematopoietic stem cell transplantation influences the further course of the disease and therefore the quality of life for patients in the same way as other therapeutic methods. The authors describe the evaluation possibilities for the quality of life and effect of selected aspects on quality of life of patients undergoing haematopoietic stem cell transplantation in the form of a review of the literature

Health-related quality of life in acute myeloid leukaemia and multiple myeloma survivors undergoing autologous progenitor stem cell transplantation: a retrospective analysis

BackgroundHaematopoietic stem cell transplantation (HSCT) is a specific therapeutic method used for biomodulation antitumour therapy of haematological malignancies and of solid tumours. It is also used for the therapy of non-tumour and hereditary diseases.AimTo analyse the selected psychosocial, health and demographic aspects of quality of life (QoL) in acute myeloid leukaemia (AML) and multiple myeloma (MM) survivors undergoing autologous progenitor stem cell transplantation (PSCT).Materials/MethodsThe total number of AML survivors was 12 (7 male, 5 female). The total number of MM survivors was 32 (18 male, 14 female). The average age of AML survivors was 47.5 years old. Average age of MM survivors was 60 years old. The Czech version of the international generic European Quality of Life Questionnaire, Version EQ-5D, was used. The effect of selected psychosocial, health and demographic aspects of QoL was determined by means of analysis of variance. The descriptive analysis was used for evaluation of QoL questionnaires.ResultsThe above-mentioned aspects proved statistically significant dependence of QoL (EQ-5D score and EQ-5D VAS) on age in both cohorts (

Quality of life in patients with multiple myeloma and malignant lymphoma undergoing autologous progenitor stem cell transplantation: The effect of selected psychosocial and health aspects on quality of life: A retrospective analysis

BackgroundQuality of life (QoL) is defined as “a patient's subjective evaluation of his life situation”. QoL evaluation is carried out by means of generic and specific questionnaires. Generic QoL questionnaires generally evaluate a patient's overall condition regardless of his disease. Specific QoL questionnaires are designed to evaluate a patient's overall condition for a particular type of disease.AimThe study analyses the effect of selected psychosocial and health aspects on quality of life in patients with multiple myeloma and malignant lymphoma undergoing autologous progenitor stem cell transplantation.Materials/MethodsThe total number of respondents undergoing transplantation between 2001 and 2003 was 56:32 respondents (18 male and 14 female) with multiple myeloma, and 24 respondents (11 male and 13 female) with malignant lymphoma. The average age of patients with multiple myeloma was 60 years and the average age of patients with malignant lymphoma was 44.5 years. The Czech version of the international generic European Quality of Life Questionnaire, Version EQ-5D, was used. The effect of selected psychosocial and health aspects (age, sex, level of education, marital status, number of associated diseases, smoking abuse, religion, type of disease and time since the transplantation) on quality of life in patients was determined by means of analysis of variance.ResultsThe above-mentioned aspects proved statistically significant dependence of quality of life on age, smoking abuse in patients with multiple myeloma and on type of disease. EQ-5D score (dimensions of quality of life) and EQ-5D VAS (subjective health condition) significantly decrease with increasing age in both groups of patients and with smoking abuse in patients with multiple myeloma, and are significantly higher in patients with malignant lymphoma. The effect of other aspects on quality of life was not proven as statistically significant. The quality of life in patients with multiple myeloma undergoing autologous progenitor stem cell transplantation is at a lower level (mean EQ-5D score 68.9%, mean EQ-5D VAS 66.6%) than in patients with malignant lymphoma after the transplantation (mean EQ-5D score 82.7%, mean EQ-5D VAS 76.7%) at the Department of Clinical Haematology of the Department of Medicine of Charles University Hospital in Hradec Kralove, Czech Republic.ConclusionThe global quality of life in our patients with multiple myeloma and malignant lymphoma undergoing autologous progenitor stem cell transplantation is at a good level

Sexuality of men treated with haematopoietic stem cell transplantation: a review of the literature

Haematopoietic stem cell transplantation (HSCT) is a therapeutic modality used in anti-tumour treatment of haematological malignancies as well as solid tumours. Apart from that it is also used in therapy of non-malignant and hereditary diseases. As well as all the other treatments, HSCT also affects the disease process and with that also the patient's quality of life (QoL). In the last decade of the 20th century several studies about QoL in patients after HSCT were undertaken and the influence in particular dimensions of QoL was observed. One of the closely observed aspects was sexuality in patients after HSCT. Sexuality and its expression is a very important aspect of human behaviour. It is also a very sensitive aspect, so without doubt it is affected by diagnosis of neoplasm and cancer treatment. Physical and psychosocial factors of HSCT affect patients' sexuality and sexual functioning, and with that also their QoL. They remain in focus because of the complex care concerning patients after HSCT

Role of plants in anticancer drug discovery

Cancer is one of the major causes of death and the number of new cases, as well as the number of individuals living with cancer, is expanding continuously. Worldwide the alarming rise in mortality rate due to cancer has fuelled the pursuit for effective anticancer agents to combat this disease. Finding novel and efficient compounds of natural origin has been a major point of concern for research in the pharmaceutical sciences. Plants have been seen to possess the potential to be excellent lead structures and to serve as a basis of promising therapeutic agents for cancer treatment. Many successful anti-cancer drugs currently in use or their analogues are plant derived and many more are under clinical trials. This review aims to highlight the invaluable role that plants have played, and continue to play, in the discovery of anticancer agents.We acknowledge the University of Pretoria for Postdoctoral fellowship to J.K. and B.A.M.http://www.elsevier.com/locate/phytolhb2017ChemistryGenetic

Moralni kompetence a moralni postoje u studentu Lekarske fakulty Univerzity Karlovy v Hradci Kralove.

Moral competence is considered as an ability, on the basis of inner principles, to pass moral judgements and to act in accordance with these judgements. Moral attitudes mainly represent an evaluating relationship partly reflecting rational knowledge, but especially reflecting subjective emotional evaluation of moral problems. The aim or our study is to evaluate moral competence and moral attitudes of Czech and foreign general medicine students at the Medical Faculty of Charles University in Hradec Kralove, and to find out the dependence of these parameters on several factors (age, school year, nationality, sex, religion and life satisfaction).In this transversal study, 310 Czech and 70 foreign students of the 1st - 5th school years have been tested by means of the Czech and English MJT versions. Moral competence in Czech students is significantly decreasing as they grow older whereas in foreign students it is non-significantly increasing. In Czech students, moral competence is significantly increasing when there is greater life satisfaction. The influence of the other factors (sex, nationality and religion) on moral competence has not been proven either in Czech, or in foreign students. The level of moral judgement is post-conventional during their entire studies. It is gratifying that our students reach the post-conventional level of moral judgement during their entire medical studies.The fact that moral competence is decreasing as they grow older can also be explained in an optimistic way - namely that the younger medical students are morally more competent than the older ones.Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi