6,506 research outputs found
Nanotube field of C60 molecules in carbon nanotubes: atomistic versus continuous tube approach
We calculate the van der Waals energy of a C60 molecule when it is
encapsulated in a single-walled carbon nanotube with discrete atomistic
structure. orientational degrees of freedom and longitudinal displacements of
the molecule are taken into account, and several achiral and chiral carbon
nanotubes are considered. A comparison with earlier work where the tube was
approximated by a continuous cylindrical distribution of carbon atoms is made.
We find that such an approximation is valid for high and intermediate tube
radii; for low tube radii, minor chirality effects come into play. Three
molecular orientational regimes are found when varying the nanotube radius.Comment: 14 pages, 9 figures, accepted for publication in Phys. Rev.
Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment.
BACKGROUND: Surgery is an important part of the management of oral cavity cancer with regard to both the removal of the primary tumour and removal of lymph nodes in the neck. Surgery is less frequently used in oropharyngeal cancer. Surgery alone may be treatment for early stage disease or surgery may be used in combination with radiotherapy, chemotherapy and immunotherapy/biotherapy. There is variation in the recommended timing and extent of surgery in the overall treatment regimens of people with these cancers. OBJECTIVES: To determine which surgical treatment modalities for oral cavity and oropharyngeal cancers result in increased overall survival, disease free survival, progression free survival and reduced recurrence. SEARCH STRATEGY: The following electronic databases were searched: the Cochrane Oral Health Group Trials Register (to 17 February 2011), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 1), MEDLINE via OVID (1950 to 17 February 2011) and EMBASE via OVID (1980 to 17 February 2011). There were no restrictions regarding language or date of publication. SELECTION CRITERIA: Randomised controlled trials where more than 50% of participants had primary tumours of the oral cavity or oropharynx, and which compared two or more surgical treatment modalities or surgery versus other treatment modalities. DATA COLLECTION AND ANALYSIS: Data extraction and assessment of risk of bias was undertaken independently by two or more review authors. Study authors were contacted for additional information as required. Adverse events data were collected from published trials. MAIN RESULTS: Seven trials (n = 669; 667 with cancers of the oral cavity) satisfied the inclusion criteria, but none were assessed as low risk of bias. Trials were grouped into three main comparisons. Four trials compared elective neck dissection (ND) with therapeutic neck dissection in patients with oral cavity cancer and clinically negative neck nodes, but differences in type of surgery and duration of follow-up made meta-analysis inappropriate. Three of these trials reported overall and disease free survival. One trial showed a benefit for elective supraomohyoid neck dissection compared to therapeutic ND in overall and disease free survival. Two trials found no difference between elective radical ND and therapeutic ND for the outcomes of overall survival and disease free survival. All four trials found reduced locoregional recurrence following elective ND.A further two trials compared elective radical ND with elective selective ND and found no difference in overall survival, disease free survival or recurrence. The final trial compared surgery plus radiotherapy to radiotherapy alone but data were unreliable because the trial stopped early and there were multiple protocol violations.None of the trials reported quality of life as an outcome. Two trials, evaluating different comparisons reported adverse effects of treatment. AUTHORS' CONCLUSIONS: Seven included trials evaluated neck dissection surgery in patients with oral cavity cancers. The review found weak evidence that elective neck dissection of clinically negative neck nodes at the time of removal of the primary tumour results in reduced locoregional recurrence, but there is insufficient evidence to conclude that elective neck dissection increases overall survival or disease free survival compared to therapeutic neck dissection. There is very weak evidence from one trial that elective supraomohyoid neck dissection may be associated with increased overall and disease free survival. There is no evidence that radical neck dissection increases overall survival compared to conservative neck dissection surgery. Reporting of adverse events in all trials was poor and it was not possible to compare the quality of life of patients undergoing different surgeries
A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200 mg oral fluconazole in Blantyre, Malawi.
OBJECTIVE: We have previously reported high ten-week mortality from cryptococcal meningitis in Malawian adults following treatment-induction with 800 mg oral fluconazole (57% [33/58]). National guidelines in Malawi and other African countries now advocate an increased induction dose of 1200 mg. We assessed whether this has improved outcomes.
DESIGN: This was a prospective observational study of HIV-infected adults with cryptococcal meningitis confirmed by diagnostic lumbar puncture. Treatment was with fluconazole 1200 mg/day for two weeks then 400mg/day for 8 weeks. Mortality within the first 10 weeks was the study end-point, and current results were compared with data from our prior patient cohort who started on fluconazole 800 mg/day.
RESULTS: 47 participants received fluconazole monotherapy. Despite a treatment-induction dose of 1200 mg, ten-week mortality remained 55% (26/47). This was no better than our previous study (Hazard Ratio [HR] of death on 1200 mg vs. 800 mg fluconazole: 1.29 (95% CI: 0.77-2.16, p = 0.332)). There was some evidence for improved survival in patients who had repeat lumbar punctures during early therapy to lower intracranial pressure (HR: 0.27 [95% CI: 0.07-1.03, p = 0.055]).
CONCLUSION: There remains an urgent need to identify more effective, affordable and deliverable regimens for cryptococcal meningitis
A Post-AGB Star in the Small Magellanic Cloud Observed with the Spitzer Infrared Spectrograph
We have observed an evolved star with a rare combination of spectral
features, MSX SMC 029, in the Small Magellanic Cloud (SMC) using the
low-resolution modules of the Infrared Spectrograph on the Spitzer Space
Telescope. A cool dust continuum dominates the spectrum of MSX SMC 029. The
spectrum also shows both emission from polycyclic aromatic hydrocarbons (PAHs)
and absorption at 13.7 micron from C2H2, a juxtaposition seen in only two other
sources, AFGL 2688 and IRAS 13416-6243, both post-asymptotic giant branch (AGB)
objects. As in these sources, the PAH spectrum has the unusual trait that the
peak emission in the 7-9 micron complex lies beyond 8.0 micron. In addition,
the 8.6 micron feature has an intensity as strong as the C-C modes which
normally peak between 7.7 and 7.9 micron. The relative flux of the feature at
11.3 micron to that at 8 micron suggests that the PAHs in MSX SMC 029 either
have a low ionization fraction or are largely unprocessed. The 13-16 micron
wavelength region shows strong absorption features similar to those observed in
the post-AGB objects AFGL 618 and SMP LMC 11. This broad absorption may arise
from the same molecules which have been identified in those sources: C2H2,
C4H2, HC3N, and C6H6. The similarities between MSX SMC 029, AFGL 2688, and AFGL
618 lead us to conclude that MSX SMC 029 has evolved off the AGB in only the
past few hundred years, making it the third post-AGB object identified in the
SMC.Comment: 4 figures, Fig. 4 color; to appear in the 20 November 2006
Astrophysical Journal Letter
Spitzer Space Telescope spectral observations of AGB stars in the Fornax dwarf spheroidal galaxy
We have observed five carbon-rich AGB stars in the Fornax dwarf spheroidal
(dSph) galaxy, using the Infrared Spectrometer on board the Spitzer Space
Telescope. The stars were selected from a near-infrared survey of Fornax and
include the three reddest stars, with presumably the highest mass-loss rates,
in that galaxy. Such carbon stars probably belong to the intermediate-age
population (2-8 Gyr old and metallicity of [Fe/H] -1) of Fornax. The primary
aim of this paper is to investigate mass-loss rate, as a function of luminosity
and metallicity, by comparing AGB stars in several galaxies with different
metallicities. The spectra of three stars are fitted with a radiative transfer
model. We find that mass-loss rates of these three stars are 4-7x10^-6 Msun
yr-1. The other two stars have mass-loss rates below 1.3x10^-6 Msun yr-1. We
find no evidence that these rates depend on metallicity, although we do suggest
that the gas-to-dust ratio could be higher than at solar metallicity, in the
range 240 to 800. The C2H2 bands are stronger at lower metallicity because of
the higher C/O ratio. In contrast, the SiC fraction is reduced at low
metallicity, due to low silicon abundance. The total mass-loss rate from all
known carbon-rich AGB stars into the interstellar medium of this galaxy is of
the order of 2x10^-5 Msun yr-1. This is much lower than that of the dwarf
irregular galaxy WLM, which has a similar visual luminosity and metallicity.
The difference is attributed to the younger stellar population of WLM. The
suppressed gas-return rate to the ISM accentuates the difference between the
relatively gas-rich dwarf irregular and the gas-poor dwarf spheroidal galaxies.
Our study will be useful to constrain gas and dust recycling processes in low
metallicity galaxies.Comment: MNRAS accepte
Carbon-rich dust production in metal-poor galaxies in the Local Group
We have observed a sample of 19 carbon stars in the Sculptor, Carina, Fornax,
and Leo I dwarf spheroidal galaxies with the Infrared Spectrograph on the
Spitzer Space Telescope. The spectra show significant quantities of dust around
the carbon stars in Sculptor, Fornax, and Leo I, but little in Carina. Previous
comparisons of carbon stars with similar pulsation properties in the Galaxy and
the Magellanic Clouds revealed no evidence that metallicity affected the
production of dust by carbon stars. However, the more metal-poor stars in the
current sample appear to be generating less dust. These data extend two known
trends to lower metallicities. In more metal-poor samples, the SiC dust
emission weakens, while the acetylene absorption strengthens. The bolometric
magnitudes and infrared spectral properties of the carbon stars in Fornax are
consistent with metallicities more similar to carbon stars in the Magellanic
Clouds than in the other dwarf spheroidals in our sample. A study of the carbon
budget in these stars reinforces previous considerations that the dredge-up of
sufficient quantities of carbon from the stellar cores may trigger the final
superwind phase, ending a star's lifetime on the asymptotic giant branch.Comment: ApJ, in press, 21 pages, 12 figures. Replaced Fig 12, corrected two
reference
The Key Role of Heavy Precipitation Events in Climate Model Disagreements of Future Annual Precipitation Changes in California
Climate model simulations disagree on whether future precipitation will increase or decrease over California, which has impeded efforts to anticipate and adapt to human-induced climate change. This disagreement is explored in terms of daily precipitation frequency and intensity. It is found that divergent model projections of changes in the incidence of rare heavy (\u3e60 mm day−1) daily precipitation events explain much of the model disagreement on annual time scales, yet represent only 0.3% of precipitating days and 9% of annual precipitation volume. Of the 25 downscaled model projections examined here, 21 agree that precipitation frequency will decrease by the 2060s, with a mean reduction of 6–14 days yr−1. This reduces California\u27s mean annual precipitation by about 5.7%. Partly offsetting this, 16 of the 25 projections agree that daily precipitation intensity will increase, which accounts for a model average 5.3% increase in annual precipitation. Between these conflicting tendencies, 12 projections show drier annual conditions by the 2060s and 13 show wetter. These results are obtained from 16 global general circulation models downscaled with different combinations of dynamical methods [Weather Research and Forecasting (WRF), Regional Spectral Model (RSM), and version 3 of the Regional Climate Model (RegCM3)] and statistical methods [bias correction with spatial disaggregation (BCSD) and bias correction with constructed analogs (BCCA)], although not all downscaling methods were applied to each global model. Model disagreements in the projected change in occurrence of the heaviest precipitation days (\u3e60 mm day−1) account for the majority of disagreement in the projected change in annual precipitation, and occur preferentially over the Sierra Nevada and Northern California. When such events are excluded, nearly twice as many projections show drier future conditions
The Peaceful Atom Comes to Campus
Youthful idealism, institutional ambition, and Cold War sensibilities all helped shape the Michigan Memorial–Phoenix Project, the University of Michigan’s tribute to fallen World War II soldiers.</jats:p
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