Antenna Axis Offset Estimation from VLBI

The antenna axis offsets were estimated from global solutions and single sessions. We have built a set of global solutions from R1 and R4 sessions and from the sets of sessions between SVETLOE repairs. We compared our estimates with local survey data for the stations of the QUASAR network. Svetloe station axis offset values have changed after repairs. For non-global networks, the axis offset value of a single station can significantly affect the EOP estimations

IAA VLBI Analysis Center Report 2012

This report presents an overview of IAA VLBI Analysis Center activities during 2012 and the plans for the coming year

The "Quasar" Network Observations in e-VLBI Mode Within the Russian Domestic VLBI Programs

The purpose of the Russian VLBI "Quasar" Network is to carry out astrometrical and geodynamical investigations. Since 2006 purely domestic observational programs with data processing at the IAA correlator have been carried out. To maintain these geodynamical programs e-VLBI technology is being developed and tested. This paper describes the IAA activity of developing a real-time VLBI system using high-speed digital communication links

Analysis of circulating tumor and cancer stem cells provides new opportunities in diagnosis and treatment of small cell lung cancer

Current methods for diagnosis and treatment of small cell lung cancer (SCLC) have only a modest efficacy. In this pilot study, we analyzed circulating tumor cells (CTCs) and cancer stem cells (CSCs) in patients with SCLC to search for new diagnostic and prognostic markers and novel approaches to improve the treatment of the disease. In other forms of lung cancer, we showed a heterogeneity of blood CTCs and CSCs populations, as well as changes in other cell populations (ALDH+, CD87+CD276+, and EGF+Axl+) in smokers. A number of CTCs and CSCs in patients with SCLC have been shown to be resistant to chemotherapy (CT). High cytotoxic activity and resistance to apoptosis of reprogrammed CD3+CD8+ T-lymphocytes (rTcells) in relation to naive CD3+CD8+ T-lymphocytes was demonstrated in a smoking patient with SCLC (Patient G) in vitro. The target for rTcells was patient G’s blood CSCs. Reprogramming of CD3+CD8+ T-lymphocytes was carried out with the MEK1/2 inhibitor and PD-1/PD-L1 pathway blocker nivolumab. The training procedure was performed with a suspension of dead CTCs and CSCs obtained from patient’s G blood. The presented data show a new avenue for personalized SCLC diagnosis and targeted improvement of chemotherapy based on the use of both CTCs and CSCs

VLBI with GNSS signals on intercontinental baselines

The International Terrestrial Reference Frame (ITRF) is constructed based on analysis results of several space geodetic techniques, among them geodetic Very Long Baseline Interferometry (VLBI) and Global Navigation Satellite Systems (GNSS). The meaningful combination of the different techniques requires possibilities to link the various instruments and their reference points. So-called co-location stations that are equipped with instrumentation for several techniques play an important role for the ITRF combination since so-called local-tie vectors on the ground enable the connection between the various instruments. Since several years, ideas have been discussed to include additional possibilities to link the different techniques, with the main goal to improve the ITRF. One of these ideas is to use GNSS signals for VLBI observations and by this improve the link between VLBI and GNSS. In our presentations we describe so-called GNSS-VLBI experiments performed in 2017 with VLBI stations at intercontinental distances. The observations, data correlation and data analysis is described and initial results are presented

Analysis of circulating tumour and cancer stem cells provides new opportunities in diagnosis and treatment of small cell lung cancer

Current methods for diagnosis and treatment of small cell lung cancer (SCLC) have only modest efficacy. In this pilot study, we analysed circulating tumour cells (CTCs) and cancer stem cells (CSCs) in patients with SCLC to search for new diagnostic and prognostic markers and novel approaches to improve the treatment of the disease. In other forms of lung cancer, we have shown a heterogeneity of blood CTCs and CSCs populations, as well as changes in other cell populations (ALDH+, CD87+CD276+ and EGF+Axl‒) in smokers. A number of CTCs and CSCs in patients with SCLC have been shown to be resistant to chemotherapy (CT). High cytotoxic activity and resistance to apoptosis of reprogrammed CD3+CD8+ T-lymphocytes (rTcells) in relation to naive CD3+CD8+ T- lymphocytes was demonstrated in a smoking patient with SCLC (Patient G) in vitro. The target for rTcells was patient G's blood CSCs. Reprogramming of CD3+CD8+ T-lymphocytes was carried out with the MEK1/2 inhibitor and PD-1/PD-L1 pathway blocker nivolumab. The training procedure was performed with a suspension of dead CTCs and CSCs obtained from patient`s G blood. The presented data show a new avenue for personalized SCLC diagnosis and targeted improvement of chemotherapy based on the use of both CTCs and CSCs

The IVS data input to ITRF2014

2015ivs..data....1N - GFZ Data Services, Helmoltz Centre, Potsdam, GermanyVery Long Baseline Interferometry (VLBI) is a primary space-geodetic technique for determining precise coordinates on the Earth, for monitoring the variable Earth rotation and orientation with highest precision, and for deriving many other parameters of the Earth system. The International VLBI Service for Geodesy and Astrometry (IVS, http://ivscc.gsfc.nasa.gov/) is a service of the International Association of Geodesy (IAG) and the International Astronomical Union (IAU). The datasets published here are the results of individual Very Long Baseline Interferometry (VLBI) sessions in the form of normal equations in SINEX 2.0 format (http://www.iers.org/IERS/EN/Organization/AnalysisCoordinator/SinexFormat/sinex.html, the SINEX 2.0 description is attached as pdf) provided by IVS as the input for the next release of the International Terrestrial Reference System (ITRF): ITRF2014. This is a new version of the ITRF2008 release (Bockmann et al., 2009). For each session/ file, the normal equation systems contain elements for the coordinate components of all stations having participated in the respective session as well as for the Earth orientation parameters (x-pole, y-pole, UT1 and its time derivatives plus offset to the IAU2006 precession-nutation components dX, dY (https://www.iau.org/static/resolutions/IAU2006_Resol1.pdf). The terrestrial part is free of datum. The data sets are the result of a weighted combination of the input of several IVS Analysis Centers. The IVS contribution for ITRF2014 is described in Bachmann et al (2015), Schuh and Behrend (2012) provide a general overview on the VLBI method, details on the internal data handling can be found at Behrend (2013)