159 research outputs found
Resourceβsaving Reserve of Strength Characteristics of Longitudinal Beam of the Metro Wagon Truck
In this paper, an analysis of methods for calculating structures from allowable stresses and from limiting states is made. It is shown that when the transition from the longitudinal beam calculation to the allowable stresses to the calculation of the limiting state, the strength limit increases by 1.5 times.A mathematical model of the stressβstrain state of a longitudinal beam of metro wagon truck without taking into account the transverse force is developed. The mathematical modeling with the given margin of strength of the power calculation of the longitudinal beam metro wagon track, which is a simple beam of a constant hollow rectangular section, pinched at its ends and loaded along the middle of the span by a concentrated stationary force, is carried out.Thus, the application of the method of calculation for the limiting state makes it possible to identify the resourceβsaving reserve of the strength characteristics of the longitudinal beam of the metro wagon truck β a 3-fold increase in the maximum permissible load
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Gender differences in the pharmacological actions of pegylated glucagon-Like peptide-1 on endothelial progenitor cells and angiogenic precursor cells in a combination of metabolic disorders and lung emphysema
In clinical practice, the metabolic syndrome (MetS) is often associated with chronic obstructive pulmonary disease (COPD). Although gender differences in MetS are well documented, little is known about sex-specific differences in the pathogenesis of COPD, especially when combined with MetS. Consequently, it is not clear whether the same treatment regime has comparable efficacy in men and women diagnosed with MetS and COPD. In the present study, using sodium glutamate, lipopolysaccharide, and cigarette smoke extract, we simulated lipid metabolism disorders, obesity, hyperglycemia, and pulmonary emphysema (comorbidity) in male and female C57BL/6 mice. We assessed the gender-specific impact of lipid metabolism disorders and pulmonary emphysema on angiogenic precursor cells (endothelial progenitor cells (EPC), pericytes, vascular smooth muscle cells, cells of the lumen of the nascent vessel), as well as the biological effects of pegylated glucagon-like peptide 1 (pegGLP-1) in this experimental paradigm. Simulation of MetS/COPD comorbidity caused an accumulation of EPC (CD45βCD31+CD34+), pericytes, and vascular smooth muscle cells in the lungs of female mice. In contrast, the number of cells involved in the angiogenesis decreased in the lungs of male animals. PegGLP-1 had a positive effect on lipids and area under the curve (AUC), obesity, and prevented the development of pulmonary emphysema. The severity of these effects was stronger in males than in females. Furthermore, PegGLP-1 stimulated regeneration of pulmonary endothelium. At the same time, PegGLP-1 administration caused a mobilization of EPC (CD45βCD31+CD34+) into the bloodstream in females and migration of precursors of angiogenesis and vascular smooth muscle cells to the lungs in male animals. Gender differences in stimulatory action of pegGLP-1 on CD31+ endothelial lung cells in vitro were not observed. Based on these findings, we postulated that the cellular mechanism of in vivo regeneration of lung epithelium was at least partly gender-specific. Thus, we concluded that a pegGLP-1-based treatment regime for metabolic disorder and COPD should be further developed primarily for male patients
Tunka Advanced Instrument for cosmic rays and Gamma Astronomy
The paper is a script of a lecture given at the ISAPP-Baikal summer school in
2018. The lecture gives an overview of the Tunka Advanced Instrument for cosmic
rays and Gamma Astronomy (TAIGA) facility including historical introduction,
description of existing and future setups, and outreach and open data
activities.Comment: Lectures given at the ISAPP-Baikal Summer School 2018: Exploring the
Universe through multiple messengers, 12-21 July 2018, Bol'shie Koty, Russi
Study of steam activation of wood coal in a reactor with external heating
As part of the development of an efficient technology for the production of activated carbon, which provides the required properties at the maximum yield of the product and the minimum expenditure of energy resources, a layer reactor with external heating is assembled and experimental studies of the steam activation of charcoal are carried out. The dependences of the activity of coal on iodine on activation time and particle size were obtained.Π ΡΠ°ΠΌΠΊΠ°Ρ
ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ³Π»Ρ, ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡΠ΅ΠΉ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ΅Π±ΡΠ΅ΠΌΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΏΡΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΌ Π²ΡΡ
ΠΎΠ΄Π΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠ° ΠΈ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΡ
Π·Π°ΡΡΠ°ΡΠ°Ρ
ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΡΡΡΡΠΎΠ², ΡΠΎΠ±ΡΠ°Π½ ΡΠ»ΠΎΠ΅Π²ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΎΡ Ρ Π²Π½Π΅ΡΠ½ΠΈΠΌ Π½Π°Π³ΡΠ΅Π²ΠΎΠΌ ΠΈ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ°ΡΠΎΠ²ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π΄ΡΠ΅Π²Π΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ³Π»Ρ. ΠΠΎΠ»ΡΡΠ΅Π½Ρ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ³Π»Ρ ΠΏΠΎ ΠΉΠΎΠ΄Ρ ΠΎΡ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΈ ΡΠ°Π·ΠΌΠ΅ΡΠ° ΡΠ°ΡΡΠΈΡ
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