Resource–saving Reserve of Strength Characteristics of Longitudinal Beam of the Metro Wagon Truck

In this paper, an analysis of methods for calculating structures from allowable stresses and from limiting states is made. It is shown that when the transition from the longitudinal beam calculation to the allowable stresses to the calculation of the limiting state, the strength limit increases by 1.5 times.A mathematical model of the stress–strain state of a longitudinal beam of metro wagon truck without taking into account the transverse force is developed. The mathematical modeling with the given margin of strength of the power calculation of the longitudinal beam metro wagon track, which is a simple beam of a constant hollow rectangular section, pinched at its ends and loaded along the middle of the span by a concentrated stationary force, is carried out.Thus, the application of the method of calculation for the limiting state makes it possible to identify the resource–saving reserve of the strength characteristics of the longitudinal beam of the metro wagon truck – a 3-fold increase in the maximum permissible load

Gender differences in the pharmacological actions of pegylated glucagon-Like peptide-1 on endothelial progenitor cells and angiogenic precursor cells in a combination of metabolic disorders and lung emphysema

In clinical practice, the metabolic syndrome (MetS) is often associated with chronic obstructive pulmonary disease (COPD). Although gender differences in MetS are well documented, little is known about sex-specific differences in the pathogenesis of COPD, especially when combined with MetS. Consequently, it is not clear whether the same treatment regime has comparable efficacy in men and women diagnosed with MetS and COPD. In the present study, using sodium glutamate, lipopolysaccharide, and cigarette smoke extract, we simulated lipid metabolism disorders, obesity, hyperglycemia, and pulmonary emphysema (comorbidity) in male and female C57BL/6 mice. We assessed the gender-specific impact of lipid metabolism disorders and pulmonary emphysema on angiogenic precursor cells (endothelial progenitor cells (EPC), pericytes, vascular smooth muscle cells, cells of the lumen of the nascent vessel), as well as the biological effects of pegylated glucagon-like peptide 1 (pegGLP-1) in this experimental paradigm. Simulation of MetS/COPD comorbidity caused an accumulation of EPC (CD45−CD31+CD34+), pericytes, and vascular smooth muscle cells in the lungs of female mice. In contrast, the number of cells involved in the angiogenesis decreased in the lungs of male animals. PegGLP-1 had a positive effect on lipids and area under the curve (AUC), obesity, and prevented the development of pulmonary emphysema. The severity of these effects was stronger in males than in females. Furthermore, PegGLP-1 stimulated regeneration of pulmonary endothelium. At the same time, PegGLP-1 administration caused a mobilization of EPC (CD45−CD31+CD34+) into the bloodstream in females and migration of precursors of angiogenesis and vascular smooth muscle cells to the lungs in male animals. Gender differences in stimulatory action of pegGLP-1 on CD31+ endothelial lung cells in vitro were not observed. Based on these findings, we postulated that the cellular mechanism of in vivo regeneration of lung epithelium was at least partly gender-specific. Thus, we concluded that a pegGLP-1-based treatment regime for metabolic disorder and COPD should be further developed primarily for male patients

Tunka Advanced Instrument for cosmic rays and Gamma Astronomy

The paper is a script of a lecture given at the ISAPP-Baikal summer school in 2018. The lecture gives an overview of the Tunka Advanced Instrument for cosmic rays and Gamma Astronomy (TAIGA) facility including historical introduction, description of existing and future setups, and outreach and open data activities.Comment: Lectures given at the ISAPP-Baikal Summer School 2018: Exploring the Universe through multiple messengers, 12-21 July 2018, Bol'shie Koty, Russi

Study of steam activation of wood coal in a reactor with external heating

As part of the development of an efficient technology for the production of activated carbon, which provides the required properties at the maximum yield of the product and the minimum expenditure of energy resources, a layer reactor with external heating is assembled and experimental studies of the steam activation of charcoal are carried out. The dependences of the activity of coal on iodine on activation time and particle size were obtained.В рамках разработки эффективной технологии производства активированного угля, обеспечивающей получение требуемых свойств при максимальном выходе продукта и минимальных затратах энергетических ресурсов, собран слоевой реактор с внешним нагревом и осуществлены экспериментальные исследования паровой активации древесного угля. Получены зависимости активности угля по йоду от времени активации и размера частиц