Acrylamide: Increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans

We have developed a liquid chromatography/mass spectrometry (LC-MS/MS) assay to determine acrylamide in various body fluids. The assay also allows the reliable quantitation of acrylamide in food. In a total of 11 healthy male and female subjects, we were able to show that acrylamide from food given to humans is in fact absorbed from the gut. The half-lives determined in two male subjects were 2.2 and 7 h. Acrylamide was found in human breast milk and penetrated the human placenta (n = 3). The variability of acrylamide concentrations found in this investigation is most likely caused by variable intersubject bioavailability and metabolism. This may be an important indication that the assessment of the risk from acrylamide for the individual may be very difficult without knowing the concentrations of acrylamide in the body. This should be considered in the design of any risk assessment study or post hoc analysis of earlier studies. At this time, we suggest that pregnant women and breast-feeding mothers avoid acrylamide-containing food. Copyright (C) 2002 S. Karger AG, Basel

Teacher Tasks for Mathematical Insight and Reorganization of What it Means to Learn Mathematics

The mathematics-for-teachers tasks we discuss in this chapter have two qualities: (1) they offer teachers opportunities to experience the pleasure of mathematical insight; and (2) they aim to disrupt and reorganize teachers\u27 views of what it means to do and learn mathematics. Given that many future and inservice elementary teachers fear and dislike mathematics, it is perhaps not too far-fetched to suggest that there is a need for “math therapy.” We believe that a form of mathematics therapy may involve new and different experiences with mathematics. Such experiences, considered broadly to include questions or prompts for mathematical exploration, draw attention to deep mathematical ideas and offer the potential of experiencing the pleasure of significant mathematical insight. In our work with teachers we have developed and used a variety of mathematics tasks as opportunities for experiential therapy. The tasks aim to challenge some of the mathematical myths that future teachers believe to be true and are typically assumed by them in mathematics classrooms. The tasks have potential to disrupt teachers\u27 view of mathematics, and to start the process for reorganizing their thinking about what mathematics is and what it means to do and learn mathematics. In this chapter we describe and discuss four of the mathematics tasks which involve non-routine mathematics problems that we use in our mathematics-for-teachers program. This program is offered annually to our 440 future elementary school (K-8) teachers, who generally lack confidence in mathematics and often fear and/or dislike the subject. It is also offered to inservice teachers through a series of mathematics-for-teachers courses. A student response summarizes the effects of our approach

On the instructional triangle and sources of justification for actions in mathematics teaching

We elaborate on the notion of the instructional triangle, to address the question of how the nature of instructional activity can help justify actions in mathematics teaching. We propose a practical rationality of mathematics teaching composed of norms for the relationships between elements of the instructional system and obligations that a person in the position of the mathematics teacher needs to satisfy. We propose such constructs as articulations of a rationality that can help explain the instructional actions a teacher takes in promoting and recognizing learning, supporting work, and making decisions.The ideas reported in this paper have been developed in part with the support of National Science Foundation grants ESI-0353285 and DRL-0918425 to the authors.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91281/1/On_the_instructional_triangle_PH&DC_May2012.pdf-

Distributive justice with and without culture

Academic treatments of distributive justice normally adopt a static approach centred on resource allocation among a set of individual agents. The resulting models, expressed in mathematical language, make no allowance for culture, as they never engage with the society’s way of life or the moulding of individuals within society. This paper compares the static approach to distributive justice with a cultural one, arguing that a case for redistribution should rest upon its cultural effects in assisting well-being and social cohesion. Unless we recognise culture, we can have little understanding of why inequalities matter, where they come from, and how they might be reduced. Redistribution may be motivated by universal value judgements taken from external sources, but it also entails internal cultural changes that refashion social relations through cumulative causation. In practical terms, it has to penetrate beyond reallocating resource endowments to bring revised attitudes in a society less tolerant of unequal outcomes. Egalitarian reforms will flourish only if they generate and reflect an egalitarian culture

Verification of electromagnetic calorimeter concept for the HADES spectrometer

The HADES spectrometer currently operating on the beam of SIS18 accelerator in GSI will be moved to a new position in the CBM cave of the future FAIR complex. Electromagnetic calorimeter (ECAL) will enable the HADES@FAIR experiment to measure data on neutral meson production in heavy ion collisions at the energy range of 2-10 A GeVon the beam of the new accelerator SIS100. Calorimeter will be based on 978 massive lead glass modules read out by photomultipliers and a novel front-end electronics. Secondary gamma beam with energies ranging from 81 MeV up to 1399 MeV from MAMI-C Mainz facility was used to verify selected technical solutions. Relative energy resolution was measured using modules with three different types of photomultipliers. Two types of developed front-end electronics as well as energy leakage between neighbouring modules under parallel and declined gamma beams were studied in detail

Coping strategies, stress, physical activity and sleep in patients with unexplained chest pain

BACKGROUND: The number of patients suffering from unexplained chest pain (UCP) is increasing. Intervention programmes are needed to reduce the chest pain and suffering experienced by these patients and effective preventive strategies are also required to reduce the incidence of these symptoms. The aim of this study was to describe general coping strategies in patients with UCP and examine the relationships between coping strategies, negative life events, sleep problems, physical activity, stress and chest pain intensity. METHOD: The sample consisted of 179 patients younger than 70 years of age, who were evaluated for chest pain at the emergency department daytime Monday through Friday and judged by a physician to have no organic cause for their chest pain. The study had a cross-sectional design. RESULTS: Emotive coping was related to chest pain intensity (r = 0.17, p = 0.02). Women used emotive coping to a greater extent than did men (p = 0.05). In the multivariate analysis was shown that physical activity decreased emotive coping (OR 0.13, p < 0.0001) while sex, age, sleep, mental strain at work and negative life events increased emotive coping. Twenty-seven percent of the patients had sleep problems 8 to14 nights per month or more. Permanent stress at work during the last year was reported by 18% of the patients and stress at home by 7%. Thirty-five percent of the patients were worried often or almost all the time about being rushed at work and 23% were worried about being unable to keep up with their workload. Concerning total life events, 20% reported that a close relative had had a serious illness and 27% had reasons to be worried about a close relative. CONCLUSION: Our results indicated that patients with more intense UCP more often apply emotive coping in dealing with their pain. Given that emotive coping was also found to be related to disturbed sleep, negative life events, mental strain at work and physical activity, it may be of value to help these patients to both verbalise their emotions and to become cognizant of the influence of such factors on their pain experience