Los objetivos de actividades de laboratorio diseñadas para la adquisición de competencia científica mediante experimentos en tiempo real : visión del alumnado

El principal objetivo del presente estudio es saber si alumnos que utilizan protocolos de laboratorio que han sido diseñados según los hallazgos de las investigaciones en didáctica para experimentos en tiempo real, son capaces de captar los objetivos de las actividades que han realizado. Se hadiseñado un marco para la elaboración de actividades, y se han creado actividades de física y química. Los alumnos de distintos países que han implementado distintas actividades son capaces de enumerar correctamente los objetivos de las mismas, asimismo la mayoría dice que los equipos con sensores les han ayudado a interpretar los resultados de los experimentos

Mechanochemical Conversion of Aromatic Amines to Aryl Trifluoromethyl Ethers

Increased interest in the trifluoromethoxy group in organic synthesis and medicinal chemistry has induced a demand for new, selective, general, and faster methods applicable to natural products and highly functionalized compounds at a later stage of hit-to-lead campaigns. Applying pyrylium tetrafluoroborate, we have developed a mechanochemical protocol to selectively substitute the aromatic amino group with the OCF3 functionality. The scope of our method includes 31 examples of ring-substituted anilines, including amides and sulfonamides. Expected SNAr products were obtained in excellent yields. The presented concise method opens a pathway to new chemical spaces for the pharmaceutical industry.Peer reviewe

Design of research-based lab sheets for the aquisition of science competencies using ICT real-time experiments : Do students get the point of what they are doing?

Konferenssikirja: http://www.esera.org/publications/esera-conference-proceedings/science-education-research-esera-2015/This study is part of a European project that aims to design new microcomputer-based laboratory (MBL) activities to be used in secondary and high school to enhance on students scientific competencies. The aim of this work is to design and to implement research-based teaching materials that take advantage of the use of MBL and promote scientific competencies in students. Researchers from six universities belonging to five EU countries have collaboratively designed a new research-based framework for MBL activities. Activities are context- based and inquiry guided. When students take experimental data, it is proposed a Predict-Observe-Explain (White & Gunstone, 1992) sequence. The main scientific competencies that the designed activities aim to enhance in students are the design of experiments, the interpretation of results and its communication. First versions of activities have been translated into national languages (German, Czech, Slovak, Finnish and Catalan) to be implemented. The study has been conducted with 865 students from five countries who have implemented the activities. Students answered a post-implementation questionnaire to elicit if they believed that they knew the objectives of the activities and if they really did. They were also asked if MBL helped them to interpret the results and if the activity could have been done without such equipment. Results obtained in this study suggest that the research-based learning materials designed to work with MBL are useful and of quality as most students in different countries understand the point of the activities, and most of them think that these activities help them to learn and that the activities could not be done without MBL. Nevertheless, differences in results have been obtained for some activities. The results of this research will be used to refine teaching materials.Peer reviewe

Synthesis and characterization of two homologous series of diastereomeric 2-alkoxyphenylcarbamates

Two homologous series of racemic diastereomeric cis- and trans-(2-dimethylaminomethylcycloheptyl)-2-alkoxyphenylcarbamates with alkyl chain lengths ranging from C1 to C8 were synthesized by stereoselective reactions. The chemical structures of these compounds were confirmed by 1H-NMR, 13C-NMR and IR spectroscopy and their physico-chemical properties were characterized. The two new series of diastereomeric compounds were tested for their local anesthetic activity and parabolic relationship between the local anesthetic activity and lipophilicity was found for both cis- and trans-series. Interestingly, cis-stereoisomers exhibited higher local anesthetic activity. © 2011 Pharmaceutical Society of Japan