Mental Health in the School System: Providing Tools and Resources for Teachers

This capstone project\u27s aim was to look at the mental health needs of school aged children, and how Occupational Therapists can help to meet their needs in the school system. The doctoral student completed a background on mental health statistics and needs in children, and also completed a literature review on occupational therapy’s role in mental health and schools, mindfulness, and current practices in the United States. A gap was identified after a literature search was completed: While the school systems understand mental health is an area that should be addressed, there is a gap in providing these tools and skills to students due to lack of confidence in educators. This capstone project served this need by partnering with one school in Lake Stevens school district. A needs assessment and observations were completed at this school with various teachers and professions. A Mindfulness Toolkit was created from evidence-based practice found in literature as well as the observations and needs assessment

Mental Health in the School System: Providing Tools and Resources For Teachers

Mental health is an important part of our everyday life. For many school aged students, mental health issues are on the rise and our roles as occupational therapists are becoming more vital. Educators also have a vital role in the mental health of their students, however their is a gap between their knowledge of mental health practices and their comfort and confidence with implementing such practices. This project aimed to bridge this gap for 5 educators in the Lake Stevens School District in Washington state. The project was comprised of a Mindfulness Toolkit that walked teachers through implementing a total of 6 different mindfulness activities with their classrooms.https://soar.usa.edu/otdcapstonespring2020/1015/thumbnail.jp

Topological metric detects hidden order in disordered media

Recent advances in microscopy techniques make it possible to study the growth, dynamics, and response of complex biophysical systems at single-cell resolution, from bacterial communities to tissues and organoids. In contrast to ordered crystals, it is less obvious how one can reliably distinguish two amorphous yet structurally different cellular materials. Here, we introduce a topological earth mover's (TEM) distance between disordered structures that compares local graph neighborhoods of the microscopic cell-centroid networks. Leveraging structural information contained in the neighborhood motif distributions, the TEM metric allows an interpretable reconstruction of equilibrium and non-equilibrium phase spaces and embedded pathways from static system snapshots alone. Applied to cell-resolution imaging data, the framework recovers time-ordering without prior knowledge about the underlying dynamics, revealing that fly wing development solves a topological optimal transport problem. Extending our topological analysis to bacterial swarms, we find a universal neighborhood size distribution consistent with a Tracy-Widom law.Comment: 23 pages, 25 figures. Fly wing analysis extended; new bacterial swarming example added; co-authors adde

Learning histories, participatory methods and creative engagement for climate resilience

The potential of place-based, historically-informed approaches to drive climate action has not yet been adequately interrogated. Recent scholarly work has focussed on climate communication and the role of arts and humanities-led storytelling in engaging people in climate narratives. Far less has been said about mobilising arts and creativity to build anticipatory climate action. perNor have archival material and pre-twentieth century histories of living with water and flood been widely utilised in this endeavour. This paper reflects on our experiences delivering the UKRI-funded Risky Cities programme and specifically, of developing and utilising a learning histories approach that folds together past, present and future in productive ways so as to learn from the past and the present and rethink the future. Risky Cities uses this approach to develop engagement tools at different scales, evaluating their impact throughout using participant interviews, reflective focus groups, and surveys. Analysing this data, we consistently find that using learning histories as the foundation of arts-led and creative community engagement makes big narratives about global climate change locally meaningful. Crucially, this drives cognitive shifts, behavioural change and anticipatory action for both participants and audiences. Thus, our learning histories approach is an important participatory tool for building climate action, empowerment and resilience

Cellular Responses and Tissue Depots for Nanoformulated Antiretroviral Therapy.

Long-acting nanoformulated antiretroviral therapy (nanoART) induces a range of innate immune migratory, phagocytic and secretory cell functions that perpetuate drug depots. While recycling endosomes serve as the macrophage subcellular depots, little is known of the dynamics of nanoART-cell interactions. To this end, we assessed temporal leukocyte responses, drug uptake and distribution following both intraperitoneal and intramuscular injection of nanoformulated atazanavir (nanoATV). Local inflammatory responses heralded drug distribution to peritoneal cell populations, regional lymph nodes, spleen and liver. This proceeded for three days in male Balb/c mice. NanoATV-induced changes in myeloid populations were assessed by fluorescence-activated cell sorting (FACS) with CD45, CD3, CD11b, F4/80, and GR-1 antibodies. The localization of nanoATV within leukocyte cell subsets was determined by confocal microscopy. Combined FACS and ultra-performance liquid chromatography tandem mass-spectrometry assays determined nanoATV carriages by cell-based vehicles. A robust granulocyte, but not peritoneal macrophage nanoATV response paralleled zymosan A treatment. ATV levels were highest at sites of injection in peritoneal or muscle macrophages, dependent on the injection site. The spleen and liver served as nanoATV tissue depots while drug levels in lymph nodes were higher than those recorded in plasma. Dual polymer and cell labeling demonstrated a nearly exclusive drug reservoir in macrophages within the liver and spleen. Overall, nanoART induces innate immune responses coincident with rapid tissue macrophage distribution. Taken together, these works provide avenues for therapeutic development designed towards chemical eradication of human immunodeficiency viral infection

Cellular Responses and Tissue Depots for Nanoformulated Antiretroviral Therapy.

Long-acting nanoformulated antiretroviral therapy (nanoART) induces a range of innate immune migratory, phagocytic and secretory cell functions that perpetuate drug depots. While recycling endosomes serve as the macrophage subcellular depots, little is known of the dynamics of nanoART-cell interactions. To this end, we assessed temporal leukocyte responses, drug uptake and distribution following both intraperitoneal and intramuscular injection of nanoformulated atazanavir (nanoATV). Local inflammatory responses heralded drug distribution to peritoneal cell populations, regional lymph nodes, spleen and liver. This proceeded for three days in male Balb/c mice. NanoATV-induced changes in myeloid populations were assessed by fluorescence-activated cell sorting (FACS) with CD45, CD3, CD11b, F4/80, and GR-1 antibodies. The localization of nanoATV within leukocyte cell subsets was determined by confocal microscopy. Combined FACS and ultra-performance liquid chromatography tandem mass-spectrometry assays determined nanoATV carriages by cell-based vehicles. A robust granulocyte, but not peritoneal macrophage nanoATV response paralleled zymosan A treatment. ATV levels were highest at sites of injection in peritoneal or muscle macrophages, dependent on the injection site. The spleen and liver served as nanoATV tissue depots while drug levels in lymph nodes were higher than those recorded in plasma. Dual polymer and cell labeling demonstrated a nearly exclusive drug reservoir in macrophages within the liver and spleen. Overall, nanoART induces innate immune responses coincident with rapid tissue macrophage distribution. Taken together, these works provide avenues for therapeutic development designed towards chemical eradication of human immunodeficiency viral infection

Validity of the WHO cutoffs for biologically implausible values of weight, height, and BMI in children and adolescents in NHANES from 1999 through 2012

The WHO cutoffs to classify biologically implausible values (BIVs) for weight, height, and weight-for-height in children and adolescents are widely used in data cleaning

Integrating Machine Learning for Planetary Science: Perspectives for the Next Decade

Machine learning (ML) methods can expand our ability to construct, and draw insight from large datasets. Despite the increasing volume of planetary observations, our field has seen few applications of ML in comparison to other sciences. To support these methods, we propose ten recommendations for bolstering a data-rich future in planetary science.Comment: 10 pages (expanded citations compared to 8 page submitted version for decadal survey), 3 figures, white paper submitted to the Planetary Science and Astrobiology Decadal Survey 2023-203

Designing financial incentives for health behaviour change: a mixed-methods case study of weight loss in men with obesity

Aim: Designing financial incentives for health behaviour change requires choices across several domains, including value (the size of the incentive), frequency of incentives, and direction (gain or loss). However, the rationale underlying complex incentive design is infrequently reported. Transparent reporting is important if we want to understand and improve the incentive development process. This paper describes a mixed methods approach for designing financial incentives for health behaviour change which involves stakeholders throughout the design process. Subject and methods: The mixed methods approach focuses on incentives for weight loss for men with obesity living in areas with high levels of disadvantage. The approach involves: (a) using an existing framework to identify all domains of a financial incentive scheme for which choices need to be made, deciding what criteria are relevant (such as effectiveness, acceptability and uptake) and making choices on each domain on the basis of the criteria; (b) conducting a survey of target population preferences to inform choices for domains and to design the incentive scheme; and (c) making final decisions at a stakeholder consensus workshop. Results: The approach was implemented and an incentive scheme for weight loss for men living with obesity was developed. Qualitative interview data from men receiving the incentives in a feasibility trial endorses our approach. Conclusion: This paper demonstrates that a mixed methods approach with stakeholder involvement can be used to design financial incentives for health behaviour change such as weight loss. Trial registration number: NCT03040518. Date: 2 February 2017