PP063—Changes in the utilisation of venlafaxine after the introduction of generics in Sweden: Implications for other countries

2013 e37 Significant but lesser changes in losartan utilization were seen in Austria and Belgium. There was no change in losartan utilization patterns in Scotland or Spain. Losartan typically generic at low prices, leading to appreciable increases in prescribing efficiency in NHS Bury, Sweden, Austria, and Belgium. There were some savings in Scotland with generic losartan. Conclusion: Multiple demand-side measures appreciably enhanced ARB prescribing efficiency. This mirrors previous findings that multiple measures are need to change prescribing habits. No significant increase in losartan utilization following generics where countries have not instigated specific measures suggests authorities cannot rely on a "spillover" effect between classes to change physician prescribing habits. This is the case even with multiple demand-side activities encouraging preferential prescribing of generics in related classes. This may be exacerbated on this occasion by a more complex message; for example, away from ACEIs first line versus ARBs to ACEIs + low cost ARBs first line. Disclosure of Interest: None declared

Regions of interest placement for DTI analyses.

<p>Representative example of ROI placements (red circles) on high-resolution T2 images (A-C, coronal orientation; D, sagittal orientation). A: thalamus, B: internal capsule (inset: corresponding MD map), C: periventricular white matter, D: cerebellar vermis</p

Ventilation and oxygenation.

<p>Ventilation and arterial blood gas measurements in lambs ventilated with an injurious strategy (black squares) versus a protective strategy (open circles) during the first 15 minutes, followed by maintenance ventilation until 1 hour. A) Tidal volume (V_T; Group: p = 0.002, F = 19.14; Time: p = 0.58, F = 0.87; Group × Time: p = 0.17, F = 1.42) B) Peak inspiratory pressure (PIP: Group: p = 0.002, F = 19.24; Time: p&lt;0.001, F = 5.72; Group × Time: p = 0.07, F = 1.70) C partial pressure of arterial (Pa) oxygen (PaO₂; Group: p = 0.87, F = 0.03; Time: p = 0.13, F = 1.6; Group × Time: p = 0.03, F = 2.2) and D) Pa carbon dioxide (PaCO₂; Group: p = 0.55, F = 0.37; Time: p = 0.49, F = 0.88; Group × Time: p&lt;0.001, F = 5.21)</p

Regions of interest placement for DTI analyses.

<p>Representative example of ROI placements (red circles) on high-resolution T2 images (A-C, coronal orientation; D, sagittal orientation). A: thalamus, B: internal capsule (inset: corresponding MD map), C: periventricular white matter, D: cerebellar vermis</p