Mise en évidence du virus de Carré dans des organes de furets par le test de précipitation en milieu gélifié

Sizaret Ph., Reculard Pierre, Labert D. Mise en évidence du virus de Carré dans des organes de furets par le test précipitation en milieu gélifié. In: Bulletin de l'Académie Vétérinaire de France tome 116 n°3, 1963. pp. 119-121

Devenir du virus dans l'organisme des porcs immunisés contre la peste classique par les vaccins vivants

Reculard Pierre, Sizaret Ph., Labert D. Devenir du virus dans l’organisme des Porcs immunisés contre la Peste classique par les vaccins vivants. In: Bulletin de l'Académie Vétérinaire de France tome 118 n°3, 1965. pp. 107-109

Influence de la gastro-entérite transmissible du porc sur la vaccination contre la peste classique par les vaccins vivants

Reculard Pierre, Sizaret Ph., Labert D. Influence de la gastro-entérite transmissible du Porc sur la vaccination contre la Peste classique par les vaccins vivants. In: Bulletin de l'Académie Vétérinaire de France tome 118 n°3, 1965. pp. 103-105

Xq27 FRAXA locus is a strong candidate for dyslexia: evidence from a genome-wide scan in French families.

Dyslexia is a frequent neurodevelopmental learning disorder. To date, nine susceptibility loci have been identified, one of them being DYX9, located in Xq27. We performed the first French SNP linkage study followed by candidate gene investigation in dyslexia by studying 12 multiplex families (58 subjects) with at least two children affected, according to categorical restrictive criteria for phenotype definition. Significant results emerged on Xq27.3 within DYX9. The maximum multipoint LOD score reached 3,884 between rs12558359 and rs454992. Within this region, seven candidate genes were investigated for mutations in exonic sequences (CXORF1, CXORF51, SLITRK2, FMR1, FMR2, ASFMR1, FMR1NB), all having a role during brain development. We further looked for 50 UTR trinucleotide repeats in FMR1 and FMR2 genes. No mutation or polymorphism co-segregating with dyslexia was found. This finding in French families with Dyslexia showed significant linkage on Xq27.3 enclosing FRAXA, and consequently confirmed the DYX9 region as a robust susceptibility locus. We reduced the previously described interval from 6.8 (DXS1227–DXS8091) to 4 Mb also disclosing a higher LOD score

Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future.

This study evaluated the consequences in Europe of the COVID-19 outbreak on pathology laboratories orientated toward the diagnosis of thoracic diseases. A survey was sent to 71 pathology laboratories from 21 European countries. The questionnaire requested information concerning the organization of biosafety, the clinical and molecular pathology, the biobanking, the workload, the associated research into COVID-19, and the organization of education and training during the COVID-19 crisis, from 15 March to 31 May 2020, compared with the same period in 2019. Questionnaires were returned from 53/71 (75%) laboratories from 18 European countries. The biosafety procedures were heterogeneous. The workload in clinical and molecular pathology decreased dramatically by 31% (range, 3%-55%) and 26% (range, 7%-62%), respectively. According to the professional category, between 28% and 41% of the staff members were not present in the laboratories but did teleworking. A total of 70% of the laboratories developed virtual meetings for the training of residents and junior pathologists. During the period of study, none of the staff members with confirmed COVID-19 became infected as a result of handling samples. The COVID-19 pandemic has had a strong impact on most of the European pathology laboratories included in this study. Urgent implementation of several changes to the organization of most of these laboratories, notably to better harmonize biosafety procedures, was noted at the onset of the pandemic and maintained in the event of a new wave of infection occurring in Europe

Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic The past and the near future

BackgroundThis study evaluated the consequences in Europe of the COVID-19 outbreak on pathology laboratories orientated toward the diagnosis of thoracic diseases.Materials and methodsA survey was sent to 71 pathology laboratories from 21 European countries. The questionnaire requested information concerning the organization of biosafety, the clinical and molecular pathology, the biobanking, the workload, the associated research into COVID-19, and the organization of education and training during the COVID-19 crisis, from 15 March to 31 May 2020, compared with the same period in 2019.ResultsQuestionnaires were returned from 53/71 (75%) laboratories from 18 European countries. The biosafety procedures were heterogeneous. The workload in clinical and molecular pathology decreased dramatically by 31% (range, 3%-55%) and 26% (range, 7%-62%), respectively. According to the professional category, between 28% and 41% of the staff members were not present in the laboratories but did teleworking. A total of 70% of the laboratories developed virtual meetings for the training of residents and junior pathologists. During the period of study, none of the staff members with confirmed COVID-19 became infected as a result of handling samples.ConclusionsThe COVID-19 pandemic has had a strong impact on most of the European pathology laboratories included in this study. Urgent implementation of several changes to the organization of most of these laboratories, notably to better harmonize biosafety procedures, was noted at the onset of the pandemic and maintained in the event of a new wave of infection occurring in Europe

Influence d’une «agression» sur la vaccination du Porc contre la Peste classique par les vaccins vivants

Reculard Pierre, Sizaret Ph., Labert D. Influence d’une «agression» sur la vaccination du Porc contre la Peste classique par les vaccins vivants. In: Bulletin de l'Académie Vétérinaire de France tome 118 n°3, 1965. pp. 101-102

Physicochemical characterization of vesicles systems formed in mixtures of protic ionic liquids and water

The formation of vesicular structures in aqueous solutions of protic ionic liquids (PILs) of synthesized diisopropylethylamine alkyl carboxylates [DIPEA][CnH2n+1COO] (n = 3–9) was demonstrated by conductivity and surfaces tension measurements and was then further investigated by morphological observation techniques such as dynamic light scattering (DLS), SAXS, freeze-fracture scanning electron microscopy (FF-SEM), and transmission electron microscopy (TEM). The presence of vesicles and a bilayer structure was determined from field optical microscopy images. All PILs studied in this work had low critical vesicular concentration (cvc) values as compared to the literature. These favorable conditions were explained by large negative values of the Gibbs free energy aggregation and were primarily due to an entropic contribution in the aggregation processes driven by hydrophobicity. This caused a decrease in the value of the effective area per molecule at the interface, and consequently an increase in the structural packing parameter P, which could give rise to the formation of vesicles. For the PILs-water systems, the size values indicated that all DIPEA PILs significantly favored the formation of vesicles. PIL vesicles were believed to have a true potential for the synthesis of other nanomaterials