Synthesis and Bioassay of Azolyl Benzothiazine Carboxamides

Cyclic sulfonamides (sultams) gained importance due to their potential pharmaceutical activity. Amongst these, 1,2-benzothiazine-1,1-dioxide and their derivatives represent the most familiar class of non-steroidal anti-inflammatory drugs (NSAIDs) available in the market. In fact, Meloxicam and Piroxicam, the members of oxicam family are used as an analgesic and anti-inflammatory drugs. Azoles are potential chemical entities with a wide range of pharmacological activities such as anticancer, antibacterial, antifungal, antiviral and antiparasitic. In continuation of our efforts to develop potential multifunctional heterocycles, we have synthesized novel azolylbenzothiazine carboxamides and studied their cytotoxic and antioxidant activities. The results of these aspects will be discussed. © 2020 Author(s).The authors Venkatapuram Padmavathi and Panga Siva Sankar are grateful to CSIR (Council of Scientific and Industrial Research), New Delhi for financial assistance under the major research project

Ecological implications of trace metals in seaweeds: Bio-indication potential for metal contamination in Wandoor, South Andaman Island

AbstractConcentration levels of Mn, Pb, Zn, Cd, Cu and Cr in six seaweed samples (Acetabularia calyculus, Corallina sp., Galaxura marginata, Sargassum duplicatum, Sargassum swartzi and Dictyota bartayresiana) were determined from Wandoor, south Andaman Island. Metals were extracted from sample homogenates and quantified by atomic absorption spectrometry. In the present investigation, heavy metal concentration levels in the following order: Mn>Pb>Cd. It is observed that Zn was only present in free floating brown seaweed S. swartzi. Cu and Cr did not show its presence in any of the seaweeds that was sampled. Metal pollution index (MPI) of six seaweed species were observed in the following decending order: A. calyculus>Corallina sp.>D. bartayresiana>G. marginata>S. duplicatum>S. swartzi. Results showed that chlorophyta, A. calyculus contained the highest concentration of heavy metals as compared to other algal species. One-way analysis of variance (ANOVA) showed that the concentration of metals was significantly different (p<0.05) with respect to different species around the study area

Did mangroves offer an effective barrier to the Thane cyclone surges?

Mangrove ecosystems support vital wetland communities of plants and animals. They are characterized by unique species of trees and shrubs that fringe the intertidal zone along sheltered coastal, estuarine and riverine areas in tropical and subtropical latitudes. Mangroves have played an important role in the economy of our coastal population for thousands of years, providing a variety of goods and services, including wood production, support for commercial and subsistence fisheries, aquaculture, salt production, and coastal erosion control

Room-temperature emitters in wafer-scale few-layer hBN by atmospheric pressure CVD

Hexagonal boron nitride (hBN) is a two-dimensional, wide band gap semiconductor material suitable for several technologies. 2D hBN appeared as a viable platform to produce bright and optically stable single photon emitters (SPEs) at room temperature, which are in demand for quantum technologies. In this context, one main challenge concerns the upscaling of 2D hBN with uniform spatial and spectral distribution of SPE sources. In this work we optimized the atmospheric-pressure chemical vapor deposition (APCVD) growth and obtained large-area 2D hBN with uniform fluorescence emission properties. We characterized the hBN films by a combination of electron microscopy, Raman and X-ray photoelectron spectroscopy techniques. The extensive characterization revealed few-layer, polycrystalline hBN films (∼3 nm thickness) with balanced stoichiometry and uniformity over 2″ wafer scale. We studied the fluorescence emission properties of the hBN films by multidimensional hyperspectral fluorescence microscopy. We measured simultaneously the spatial position, intensity, and spectral properties of the emitters, which were exposed to continuous illumination over minutes. Three main emission peaks (at 538, 582, and 617 nm) were observed, with associated replica peaks red-shifted by ∼53 nm. A surface emitter density of ∼0.1 emitters/μm2 was found. A comparative test with pristine hBN nanosheets produced by liquid-phase exfoliation (LPE) was performed, finding that CVD and LPE hBN possess analogous spectral emitter categories in terms of peak position/intensity and density. Overall, the line-shape and wavelength of the emission peaks, as well as the other measured features, are consistent with single-photon emission from hBN. The results indicate that APCVD hBN might proficiently serve as a SPE platform for quantum technologies.We acknowledge the financial support of i) the project “GEMIS – Graphene-enhanced Electro Magnetic Interference Shielding,” with the reference POCI-01-0247-FEDER-045939, co-funded by COMPETE 2020 – Operational Programme for Competitiveness and Internationalization and FCT –Science and Technology Foundation, under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); ii) the project "Graphene and novel thin films for super-resolution microscopy and bio-sensing" (PTDC/NAN-OPT/29417/2017) financed by ERDF, through the Competitiveness and Internationalization Operational Program (POCI) by Portugal 2020 and by the Portuguese Foundation for Science and Technology (FCT) with references POCI-01-0145-FEDER-029417 and PTDC/NAN-OPT/29417/2017; iii) the FCT in the framework of the Strategic Funding UIDB/04650/2020. One of the authors (T.Q.) acknowledges the FCT financial support under the Quantum Portugal Initiative Ph.D. scholarship SFRH/BD/150646/2020. We acknowledge the support by the INL AEMIS, Micro- and Nanofabrication, and Nanophotonics and Bioimaging research core facilities

Voltammetric behaviour of nifedipine

861-863The electrochemical reduction behaviour of nifedipine has been studied by employing advanced electrochemical techniques in different supporting electrolytes. Analytical estimation of nifedipinein pharmaceutical formulations and in presence of some nitroimidazoles, employing differential pulse polarography is also discussed

Respiratory responses in freshwater fish Channa punctatus (Bloch) during sublethal toxicity of deltamethrin in relation to sex

Oxygen consumption plays an imperative role in the life of all organisms. The air we breathe, the food we eat, and the water we drink, are contaminated by toxic substances. In the present study, Channa punctatus (BLOCH) was used as an animal model to determine the sublethal toxicity of deltamethrin. Males weighing 10 + 2g and females weighing 12 + 2g were divided into groups of ten each and were exposed to different concentrations of Deltamethrin ranging from 0.02 ppm to 0.2 ppm. Five exposure periods i.e. 24 h, 7, 15, 20 and 30 days were selected for determination of respiratory responses i.e. time course oxygen consumption and whole animal oxygen consumption of both sexes of fish to the imposed toxic stress at these periods of exposure. In the whole animal, the rate of oxygen consumption in males and females Channa punctatus in relation to control was initially elevated at 24 h and declined thereafter at 7 and 15 days of exposure periods, and at the end of 30 days exposure there was a rise in oxygen consumption from its earlier maximum suppression and came nearer to the control in both sexes.Key words: deltamethrin, sublethal toxicity, oxygen consumption and Channa punctatus