A COMPARATIVE CLINICAL STUDY OF ASWAGANDHA KSHARA IN THE MANAGEMENT OF KAPHAJA KASA

Kaphaja Kasa is most prevalent disorder of Pranavaha Srotas, if not treated properly; it can lead to serious diseases like Swasa, Kshaya etc. The cordial symptoms of Kaphaja kasa are Kasa, Pinasa, Kaphasteevana, Jvara, Prabhutaghana, Snigdha and Bahala kapha. It is equivalent to acute and chronic bronchitis in modern medicine is an airway inflammatory disorder. Aswagandha is a miracle and very common plant drug in our country mainly used in Ayurveda for different disease conditions and also as a preventive medicine. The method adopted in present study is randomized open label clinical trial before and after the treatment. A randomized clinical study was conducted on 30 patients with Aswagandhakshara prepared from different plant parts, patients were divided into three groups, each group consisting of 10 patients. In all subjects, history taking, clinical examination and laboratory investigations were done as per the case sheet proforma advocated by CCRAS, Kshara prepared from aerial parts shows extremely significant results on Kaphasteevana, Pinasa, Eosinophils, ESR level, very significant results in Jvara, TC, and ESR level, Kshara prepared from roots and aerial parts shown extremely significant result on Pinasa and ESR level, very significant results on Kasa, Kaphasteevana, Eosinophils and Kshara prepared from roots has shown very significant result on ESR level. The overall result showed that the medicine was effective in patients who were administered Kshara prepared from aerial parts

A CLINICAL STUDY OF MARKET SAMPLES OF NAGAKESARA IN THE MANAGEMENT OF POLY CYSTIC OVARIAN DISEASE (PCOD)

This study was conducted to evaluate the efficacy of different market samples of Nagakesara in cases of PCOD. In this study 30 patients were divided into 3 groups. Group 1: MF Group (Mesua ferrea Linn. powder with milk), Group 2: OL Group (Ochrocarpus longifolium Benth & Hook. f; powder with milk), Group 3: CT Group (Cinnamomum tamala Nees & Ebern powder with milk) and advocated the trial drug with a dosage of 40-50mg/kg body weight per day for a duration of 3months with a follow up of every 15days. Subjective parameters like duration of menstruation, gap between two cycles, pain during menstruation, quantity of menstrual bleeding, Acne, Hirsutism, Acanthosis nigracans, Obesity are taken and results were analyzed statistically before and after treatment. Group 1 showed that 10% of the patients recovered completely, 55.09% recovered moderately and 35% remains unchanged. Group 2 showed that 10% of the patients recovered completely, 45.66% moderately and 44% remains unchanged. Group 3 showed that 0% of the patients recovered completely, 52% recovered moderately and 48% remains unchanged. Mesua ferrea showed extremely significant result i.e., P<0.001 in duration of menstruation (67.85%), gap between two cycles (65.62%), quantity of menstrual bleeding (66.66%). All the observations related to the total effect of therapy suggests that patients of Group 1 were well responded to the therapy than the patients of Group 2 and Group 3. Conclusion: The present comparative clinical study shows that the Amapachana property, the capacity to induce ovulation and reduction in the clinical features are more clearly observed in Mesua ferrea Linn. than in others

A CLINICAL STUDY OF MUSTA (CYPERUS ROTUNDUS LINN.) IN HYPERLIPIDAEMIA

Hyperlipidaemia is a metabolic disorder in population diagnosed by altered levels of Lipoproteins, Cholesterol and Triglycerides in plasma. This results deposition of lipids especially esterified cholesterol in the wall of arteries resulting in the narrowing and blockage of the arteries leading to heart diseases and other diseases such as cerebrovascular disease, renal disease, liver disease and peripheral vascular disease. The present work focused on comparative analysis of anti-hyperlipidaemic profile of Musta (Cyperus rotundus Linn.) in Male and female patients. The patients suffering from Hyperlipidaemia and its related disorders like non-insulin dependent diabetes etc. were divided into two groups, Group A confined to male and Group B confined to female. Each group contains 15 patients. All the patients were advised to take 3 gm powdered Musta rhizome in two or three divided doses for a period of 45 days. After treatment, Musta rhizome powder showed more significant anti-hyperlipidaemic activity in males than females. The significance in males total cholesterol (p<0.05), HDL (p<0.05), VLDL (p<0.05), triglycerides (p<0.05) is more than that of females VLDL (p>0.05), triglycerides (p>0.05). It is observed that in group A 40% patients got complete relief, 6.67 % patients got marked relief, 33.33% patients got moderate relief and 20 % patients got mild relief. Similarly, in group B patients 06.67% patients got complete relief, 6.67 % patients got marked relief, 53.33% patients got moderate relief and 33.33 % patients got mild relief

INDICATION OF VEDIC PLANTS AVAILABLE IN THE PRESENT ERA

Vedas which are four in number are actually derived from the voice of Lord Brahma deva heard by our ancient Rishis. They contain hymns about the many forms of Omnipotent Lord of the universe. In Vedas, many references are available on many plants which are used in rituals, sacrifices and medicines. Many common and rare diseases were treated with the help of these plants.Some plants mentioned in Vedic literature are known with the same name even today and are under continuous utility since that period. Their therapeutic values are boundless and amazing. As all these plants are native to our country they are available readily in our near vicinity. Many plants have been mentioned in the Vedic literature. Some of them are Prishni parni, Shami, Udumbara, Apamarga, Ashikni, Aswattha, Rajani and Nyastika. Fifteen plants which are known for the therapeutic value and are easily available are studied and enumerated for their therapeutic values in the Vedic literature, Ayurvedic and latest scientific literature. Comparision of the therapeutic uses from the Vedic literature to the ayurvedic literature is done and studied the similarities and differences. It is found that for most of the plants, the therapeutic uses are similar from the Vedic and Ayurvedic literature.This study helps to compare the past and present indications of Vedic plant drugs. Some new indications are found to be promising to pave a perfect way to cure some modern diseases also.

A PHARMACOGNOSTIC AND PHYTOCHEMICAL STUDY ON THE MARKET SAMPLES OF NAGAKESARA

This work was conducted to evaluate the pharmacognostic and phytochemical study of varieties of Nagakesara. When it is further studied, it is observed that Nagakesara available in the markets of different areas is from different source plants. There are nearly 5 drugs sold in the market with the same name, the common floral parts available in the markets are commonly from Nagakesara (Mesua ferrea Linn.), Surapunnaga (Ochrocarpus longifolius Benth and Hook f.), Tamalpatra (Cinnamomum tamala Nees and Ebern.), Punnaga (Calophyllum inophyllum Linn.), Dillenia pentagyna Roxb. Hence a comparative study of these two samples 1) Nagakesara (Mesua ferrea), and 2) Tamalpatra (Cinnamomum tamala) has been carried out. The phytochemical study shows the presence of tannins, steroids and carbohydrates in almost all varieties of Nagakesara. Flower buds of Nagakesara plant of different species available in the market was taken up for the study. CONCLUSION: A detailed Pharamcognostic and Phytochemical review was done through which it was concluded that Mesua ferrea Linn. belonging to family Guttiferae may be the exact source of Nagakesara. The flower buds of Cinnamomum tamala Nees and Ebern. which is known as black variety in the markets according to our study,

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of Dermatogenic Diseases in Chittoor District, Andhra Pradesh, India

An ethno-medicobotanical survey of plants used in the treatment of dermatogenic diseases in Chittoor District, Andhra Pradesh was conducted. The information was collected on the basis of personal interviews with traditional healers, tribal doctors and old women of the society. The investigation revealed that 24 plant species belonging to 18 families and 21 genera are commonly used in the treatment of skin ailments

A Critical study of Pramehahara effect of Dhaatri Nishe w.s.r. to Diabetes mellitus

Nishaamlaki is a known Ayurvedic medicinal preparation which is found effective in controlling the Diabetes mellitus. But according to Astanga hridaya “Meheshudhaatrinishe” combination of Aamlaki and two Haridra drugs effectively controls Prameha.Here the word “NISHE” indicates two drugs i.e., Haridra and Daruharidra.The combination of Aamlaki (Emblica officinalis Linn.) Haridra (Curcuma longa Linn.) and Daruharidra (Berberis aristata D.C & Coscinium fenestratum Colebr.) is to be considered as “Srestha” (Drug of choice) in Diabetes mellitus. India leads the world’s largest number of diabetic subjects earning the dubious distinction of being termed the diabetes capital of the world. According to diabetes atlas 2008 published by Indian diabetic federation, the number of people with diabetes in India are currently around 40.9 million and is expected to rise to 69.9 million by 2025 unless urgent preventive measures are  taken. In India, it is also 3rd leading cause of death (After heart disease and cancer).It has turned out to be the biggest “silent killer” in today’s world. The present research work is done on 60 patients dividing them into 2 groups.DH1 Group was given with Aamalaki, Haridra and Daruharidra {Berberis aristata D.C}, DH2 Group was given with Aamalaki, Haridra and Daruharidra {Coscinium fenestratum Colebr.}. Finally it is concluded that Daruharidra which is known botanically as Berberis aristata D.C is highly effective in controlling the blood sugar levels in combination with Aamalaki and Haridra than Coscinium fenestratum Colebr. in combinations with Aamalaki and Haridra. &nbsp

A Comparative Clinical Study of Two Varieties of Haritaki, Terminalia Chebula Retz. and Terminalia Pallida Brandis in Kaphaja Kasa

Kasa, is a disease effecting Pranavaha srotas. It may develop as an independent disease or may be a Lakshana associated to other disease or sometimes may develop as Upadrava of a disease. It is the one of the most prevalent disorder that is annoying the individual and resulting in the change of lifestyle nowadays. Many Ayurvedic drugs are mentioned for the treatment of Kasa, of which Haritaki is one of the drugs, which is easily available and used extensively for the treatment. The present clinical study was carried out to study the comparative role of two types of Haritaki, Terminalia chebula Retz. and Terminalia pallida Brandis. in relieving Kaphaja Kasa. The Clinical trial was conducted on 30 patients between the age group 16 to 60 years. The study is a randomized clinical study and the patients were divided into two groups; each group consisted of 15 patients. Group-A patients were treated with Churnam tablets prepared of Terminalia chebula Retz. and Group-B patients were treated with Churnam tablets prepared of Terminalia pallida Brandis., Hot water was advised as Anupana. The results were analyzed statistically. The analysis suggested that the Group-B were more effective than Group-A in reducing the signs and symptoms of Kaphaja Kasa

A Study of Certain Ayurvedic Plants Containing Steroidal Saponins with Anti Inflammatory Activity

Inflammation is the local reaction of living tissue. The bacterial infections without inflammation would remain un encountered, such kinds of wounds will never heal, the tissues get injured and the organs might be permanently damaged. Detailed investigations have been undertaken on several plants for Anti - inflammatory activity. The most common screening model has been the prevention of Carrageenan induced edema in rats. The pure compounds investigated for Anti - inflammatory activity had diverse chemical structures. Extensive research has been carried out in the membrane permeability, immune stimulant, Hypo cholesterolemic, Anti-inflammatory properties of Saponins. In the plant kingdom large number of biologically active compounds like Saponins glycosides are present. Most of the plants having Saponin glycosides are medicinally important. Many glycosides are used in traditional and modern medicines because of their cardio tonic, analgesic, anti-rheumatic other useful actions. The present study is therefore focussed on discussing the various Ayurvedic medicinal plants having Saponins with Anti- inflammatory action. Method: Classical Ayurvedic texts along with the commentaries and modern literature was collected from Modern books, Journals were carefully studied to compile information about plants containing Saponins and to evaluate with Anti-inflammatory action. It was observed that these Saponin containing plants having different karmas and these karmas having Sotha hara property (Anti-inflammatory activity). Results and conclusion: The below mentioned 10 plants are time tested and mentioned in the classical literature and indicated in many inflammatory disorders with significant rate of success. The study helps to establish a potent drug from the existing formulary. &nbsp

Identity of certain species of plants of unknown source from Rasendramangala

Combination of plant and mineral products were derived in the process of exploring safe and effective remedies which can cure severe and deadly diseases. Some plants are used for processing, purification and calcination of minerals, metals and gems. Mainly the purpose of plants in Rasa shastra is to obtain absorbable metallic molecules in the maximum possible minute form. But some plants mentioned in textbook of Rasa-shastra are not identified properly, because Rasa siddhas like Nagarjuna and Rasa Vagbhata have used some rare synonyms of plants, to conceal them from the knowledge of unknown and mischievous personalities, to avoid misuse. But at present, it is necessary to identify them properly, to use the plants for exact calcination and purification for the benefit of mankind. In the present study, nearly ten plants out of 47 unidentified plants are selected from Rasendra Mangala written by Acharya Nagarjuna in the period of 7th and 8th Century A.D. and a trial has been made to work out on such unidentified plants depending upon their synonyms, utility and combination with other drugs. To quote some, Kanchuki, Chandali, Choraka, Chandravalli and Sarpakshi. &nbsp