Investigation of peak shapes in the MIBETA experiment calibrations

In calorimetric neutrino mass experiments, where the shape of a beta decay spectrum has to be precisely measured, the understanding of the detector response function is a fundamental issue. In the MIBETA neutrino mass experiment, the X-ray lines measured with external sources did not have Gaussian shapes, but exhibited a pronounced shoulder towards lower energies. If this shoulder were a general feature of the detector response function, it would distort the beta decay spectrum and thus mimic a non-zero neutrino mass. An investigation was performed to understand the origin of the shoulder and its potential influence on the beta spectrum. First, the peaks were fitted with an analytic function in order to determine quantitatively the amount of events contributing to the shoulder, also depending on the energy of the calibration X-rays. In a second step, Montecarlo simulations were performed to reproduce the experimental spectrum and to understand the origin of its shape. We conclude that at least part of the observed shoulder can be attributed to a surface effect

Embryo disposal practices in IVF clinics in the United States

BACKGROUND. The moral status of the human embryo is particularly controversial in the United States, where one debate has centered on embryos created in excess at in vitro fertilization (IVF) clinics. Little has been known about the disposal of these embryos. METHODS.We mailed anonymous, self-administered questionnaires to directors of 341 American IVF clinics. RESULTS. 217 of 341 clinics (64 percent) responded. Nearly all (97 percent) were willing to create and cryopreserve extra embryos. Fewer, but still a majority (59 percent), were explicitly willing to avoid creating extras. When embryos did remain in excess, clinics offered various options: continual cryopreservation for a charge (96 percent) or for no charge (4 percent), donation for reproductive use by other couples (76 percent), disposal prior to (60 percent) or following (54 percent) cryopreservation, and donation for research (60 percent) or embryologist training (19 percent). Qualifications varied widely among those personnel responsible for securing couples’ consent for disposal and for conducting disposal itself. Some clinics performed a religious or quasi-religious disposal ceremony. Some clinics required a couple’s participation in disposal; some allowed but did not require it; some others discouraged or disallowed it. CONCLUSIONS. The disposal of human embryos created in excess at American IVF clinics varies in ways suggesting both moral sensitivity and ethical divergence

On shape dependence of holographic entanglement entropy in AdS4/CFT3 with Lifshitz scaling and hyperscaling violation

We study the divergent terms and the finite term in the expansion of the holographic entanglement entropy as the ultraviolet cutoff vanishes for smooth spatial regions having arbitrary shape, when the gravitational background is a four dimensional asymptotically Lifshitz spacetime with hyperscaling violation, in a certain range of the hyperscaling parameter. Both static and time dependent backgrounds are considered. For the coefficients of the divergent terms and for the finite term, analytic expressions valid for any smooth entangling curve are obtained. The analytic results for the finite terms are checked through a numerical analysis focussed on disks and ellipses

A new regression model for the forecasting of COVID-19 outbreak evolution: an application to Italian data

none5noThe novel coronavirus SARS-CoV-2 was first identified in China in December 2019. In just over five months, the virus affected over 4 million people and caused about 300,000 deaths. This study aimed to model new COVID-19 cases in Italian regions using a new curve. A new empirical curve is proposed to model the number of new cases of COVID-19. It resembles a known exponential growth curve, which has a straight line as an exponent, but in the growth curve proposed, the exponent is a logistic curve multiplied for a straight line. This curve shows an initial phase, the expected exponential growth, then rises to the maximum value and finally reaches zero. We characterized the epidemic growth patterns for the entire Italian nation and each of the 20 Italian regions. The estimated growth curve has been used to calculate the expected time of the beginning, the time related to peak, and the end of the epidemics. Our analysis explores the development of the outbreaks in Italy and the impact of the containment measures. Data obtained are useful to forecast future scenarios and the possible end of the epidemic.openD. Sisti, S. Amatori, E. Rocchi, S. Peluso, M. CarlettiSisti, D.; Amatori, S.; Rocchi, E.; Peluso, S.; Carletti, M

Homologs of the LapD-LapG c-di-GMP effector system control biofilm formation by <i>Bordetella bronchiseptica</i>

Biofilm formation is important for infection by many pathogens. Bordetella bronchiseptica causes respiratory tract infections in mammals and forms biofilm structures in nasal epithelium of infected mice. We previously demonstrated that cyclic di-GMP is involved in biofilm formation in B. bronchiseptica. In the present work, based on their previously reported function in Pseudomonas fluorescens, we identified three genes in the B. bronchiseptica genome likely involved in c-di-GMP-dependent biofilm formation: brtA, lapD and lapG. Genetic analysis confirmed a role for BrtA, LapD and LapG in biofilm formation using microtiter plate assays, as well as scanning electron and fluorescent microscopy to analyze the phenotypes of mutants lacking these proteins. In vitro and in vivo studies showed that the protease LapG of B. bronchiseptica cleaves the N-terminal domain of BrtA, as well as the LapA protein of P. fluorescens, indicating functional conservation between these species. Furthermore, while BrtA and LapG appear to have little or no impact on colonization in a mouse model of infection, a B. bronchiseptica strain lacking the LapG protease has a significantly higher rate of inducing a severe disease outcome compared to the wild type. These findings support a role for c-di-GMP acting through BrtA/LapD/LapG to modulate biofilm formation, as well as impact pathogenesis, by B. bronchiseptica.Facultad de Ciencias ExactasInstituto de Biotecnologia y Biologia Molecula

Physical activity, sedentary behaviour and screen time among youths with Down syndrome during the COVID-19 pandemic

Background: The COVID-19-related restrictions hampered habitual physical activity (PA), particularly affecting the more vulnerable, such as people with Down syndrome (DS). The study aimed to investigate changes in PA, sedentary behaviour (SB) and screen time (ST) of youths with DS, before, during and after the restrictions, also in relation to parental PA levels. Methods: A cross-sectional design with a retrospective assessment of variables for the before and during restrictions periods was adopted. Parents of youths with DS completed an online questionnaire. Sociodemographic aspects, weekly PA levels and youths' daily SB and ST were investigated, referring to three time-points: before the pandemic, during the restrictions and the restrictions-easing phase. Results: A total of 57 parents voluntarily participated in the study, proxy-reporting on their child (male = 41, female = 16, age = 21.4 ± 7.7 years). A repeated measures multivariate analysis of variance showed negative effects of restrictions (P < 0.05) on PA levels, SB and ST, independently from sociodemographic characteristics. In the restrictions-easing phase, PA levels did not return to before the pandemic values (P < 0.05). A positive correlation between parents and their child's PA was detected before the pandemic (r = 0.38; P < 0.01), no longer reported in the restrictions-easing phase. Conclusions: The findings showed the negative impact of restrictions on youths with DS lifestyle. Moreover, the importance of addressing the needs of the disabled community including the whole family is highlighted

The Microcalorimeter Arrays for a Rhenium Experiment (MARE): a next-generation calorimetric neutrino mass experiment

Neutrino oscillation experiments have proved that neutrinos are massive particles, but can't determine their absolute mass scale. Therefore the neutrino mass is still an open question in elementary particle physics. An international collaboration is growing around the project of Microcalorimeter Arrays for a Rhenium Experiment (MARE) for directly measuring the neutrino mass with a sensitivity of about 0.2eV/c2. Many groups are joining their experiences and technical expertise in a common effort towards this challenging experiment. We discuss the different scenarios and the impact of MARE as a complement of KATRIN.Comment: 3 pages, 1 figure Nucl. Instr. Meth. A, proceedings of LTD11 workshop, Tokyo 200

From food waste to eco-friendly functionalized polymer composites: Investigation of orange peels as active filler

: The development of eco-friendly polymer composites with multifunctional properties aligns with the goals of the circular economy agenda, which aims to minimize waste and promote the sustainable use of resources by closing the loop of product life cycles. Eco-friendly polymer composites play a crucial role in achieving these objectives. The present work focuses on the preparation of fully biobased blends obtained by melt mixing a bio-polyester, poly(butylene succinate-co-adipate) (PBSA), with orange peels up to 20&nbsp;wt%, to yield active polymer composites. Orange peels, employed here as natural filler, are largely available from food wastes, they are rich in phenolic compounds and possess antioxidant activity as shown by the experimental tests carried out. The thermal stability of the formulated composites is almost unchanged by the filler addition, showing only a slight decrease of the crystallization temperatures and crystalline fraction within the composites. The mechanical properties of the compounds evidence an increase in the elastic modulus together with a decrease in the tensile strength, while the elongation at break remains almost constant. The incorporation of the natural filler enabled the integration of antioxidant and antibacterial properties, which were absent in the original pristine polymer