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A molecular insight into the lipid changes of pig Longissimus thoracis muscle following dietary supplementation with functional ingredients

: In this work, the Longissimus thoracis pig skeletal muscle was used as a model to investigate the impact of two different diets, supplemented with n-3 polyunsaturated fatty acids from extruded linseed (L) and polyphenols from grape skin and oregano extracts (L+P), on the lipidomic profile of meat. A standard diet for growing-finishing pigs (CTRL) was used as a control. Changes in lipids profile were investigated through an untargeted lipidomics and transcriptomics combined investigation. The lipidomics identified 1507 compounds, with 195 compounds fitting with the MS/MS spectra of LipidBlast database. When compared with the CTRL group, the L+P diet significantly increased 15 glycerophospholipids and 8 sphingolipids, while the L diet determined a marked up-accumulation of glycerolipids. According to the correlations outlined between discriminant lipids and genes, the L diet may act preventing adipogenesis and the related inflammation processes, while the L+P diet promoted the expression of genes involved in lipids' biosynthesis and adipogenic extracellular matrix formation and functioning

Euclid preparation : II. The EUCLIDEMULATOR - a tool to compute the cosmology dependence of the nonlinear matter power spectrum

We present a new power spectrum emulator named EuclidEmulator that estimates the nonlinear correction to the linear dark matter power spectrum depending on the six cosmological parameters ωb, ωm, ns, h, w0, and σ8. It is constructed using the uncertainty quantification software UQLab using a spectral decomposition method called polynomial chaos expansion. All steps in its construction have been tested and optimized: the large highresolution N-body simulations carried out with PKDGRAV3 were validated using a simulation from the Euclid Flagship campaign and demonstrated to have converged up to wavenumbers k ≈ 5 h Mpc−1 for redshifts z ≤ 5. The emulator is based on 100 input cosmologies simulated in boxes of (1250 Mpc/h)3 using 20483 particles. We show that by creating mock emulators it is possible to successfully predict and optimize the performance of the final emulator prior to performing any N-body simulations. The absolute accuracy of the final nonlinear power spectrum is as good as one obtained with N-body simulations, conservatively, ∼1 per cent for k 1 h Mpc−1 and z 1. This enables efficient forward modelling in the nonlinear regime, allowing for estimation of cosmological parameters using Markov ChainMonteCarlo methods. EuclidEmulator has been compared to HALOFIT, CosmicEmu, and NGenHalofit, and shown to be more accurate than these other approaches. This work paves a new way for optimal construction of future emulators that also consider other cosmological observables, use higher resolution input simulations, and investigate higher dimensional cosmological parameter spaces.Peer reviewe

Test Report of NISP dedicated test activities during the CSL campaign - DCU-SCE Communication issue

A complete analysis of the communication issue in the science interface observed during the NISP CSL test campaig