Wall Chair Window

As a continuation of the zoom studies, students were asked to create a wall, a chair, and a window using only a single piece of 8 x 8 material

Chiasma

Newspaper reporting on events at the Boston University School of Medicine in the 1960s

Repeated reunions and splits feature the highly dynamic evolution of 5S and 35S ribosomal RNA genes (rDNA) in the Asteraceae family

<p>Abstract</p> <p>Background</p> <p>In flowering plants and animals the most common ribosomal RNA genes (rDNA) organisation is that in which 35S (encoding 18S-5.8S-26S rRNA) and 5S genes are physically separated occupying different chromosomal loci. However, recent observations established that both genes have been unified to a single 35S-5S unit in the genus <it>Artemisia </it>(Asteraceae), a genomic arrangement typical of primitive eukaryotes such as yeast, among others. Here we aim to reveal the origin, distribution and mechanisms leading to the linked organisation of rDNA in the Asteraceae by analysing unit structure (PCR, Southern blot, sequencing), gene copy number (quantitative PCR) and chromosomal position (FISH) of 5S and 35S rRNA genes in ~200 species representing the family diversity and other closely related groups.</p> <p>Results</p> <p>Dominant linked rDNA genotype was found within three large groups in subfamily Asteroideae: tribe Anthemideae (93% of the studied cases), tribe Gnaphalieae (100%) and in the "Heliantheae alliance" (23%). The remaining five tribes of the Asteroideae displayed canonical non linked arrangement of rDNA, as did the other groups in the Asteraceae. Nevertheless, low copy linked genes were identified among several species that amplified unlinked units. The conserved position of functional 5S insertions downstream from the 26S gene suggests a unique, perhaps retrotransposon-mediated integration event at the base of subfamily Asteroideae. Further evolution likely involved divergence of 26S-5S intergenic spacers, amplification and homogenisation of units across the chromosomes and concomitant elimination of unlinked arrays. However, the opposite trend, from linked towards unlinked arrangement was also surmised in few species indicating possible reversibility of these processes.</p> <p>Conclusions</p> <p>Our results indicate that nearly 25% of Asteraceae species may have evolved unusual linked arrangement of rRNA genes. Thus, in plants, fundamental changes in intrinsic structure of rDNA units, their copy number and chromosomal organisation may occur within relatively short evolutionary time. We hypothesize that the 5S gene integration within the 35S unit might have repeatedly occurred during plant evolution, and probably once in Asteraceae.</p

The Specter of Malpractice: When Law Firm General Counsel and Risk Management Professionals Are Confronted with Potential Malpractice Claims and Ethics Violations

Every day, law firm general counsel and other law firm risk management professionals face a very practical, very vexing problem. The problem is what to do when hearing that a serious ethical mistake or impropriety may have occurred—but without any concrete confirmation that something problematic has, in fact, happened. This essay discusses the most important initial steps and questions that the firm’s general counsel or other risk management professional must address in this confounding situation where the “specter of malpractice” is present. We call this the “specter of malpractice” because a malpractice claim has not yet fully materialized (and it is not entirely clear that one will materialize), but enough risk factors have surfaced to capture the risk management team’s attention. Included among these important and difficult questions are: Could this type of mistake constitute an ethics violation or a future malpractice claim? What duty does a firm’s general counsel or risk management professional have to investigate the situation? What action is required with respect to the firm’s legal malpractice insurer and when should the law firm take that action? What action is required with respect to the law firm’s clients and when should the law firm take that action? We answer these questions in our short (under 5,000 words) essay, reminding our readers that “an ounce of prevention is worth a pound of cure.

Irredentism and Institutions

Why do states engage in irredentism? Expanding on previous scholarship, this article advances a new theory with rationalist microfoundations that accounts for the incentives of both elites and citizens to support irredentism in democracies and dictatorships. Our model suggests irredentism is more likely when it enables political elites to provide a specific mix of private goods, public goods, and welfare transfers to citizens who desire them at the lowest tax rate. This leads to the prediction that irredentism is most likely in majoritarian democratic electoral systems and military dictatorships, and least likely in proportional electoral systems and single-party dictatorships. We test and find supportive evidence for these expectations using a comprehensive dataset covering all observed and potential irredentist cases from 1946 to 2014

Deep learning for inferring cause of data anomalies

Daily operation of a large-scale experiment is a resource consuming task, particularly from perspectives of routine data quality monitoring. Typically, data comes from different sub-detectors and the global quality of data depends on the combinatorial performance of each of them. In this paper, the problem of identifying channels in which anomalies occurred is considered. We introduce a generic deep learning model and prove that, under reasonable assumptions, the model learns to identify 'channels' which are affected by an anomaly. Such model could be used for data quality manager cross-check and assistance and identifying good channels in anomalous data samples. The main novelty of the method is that the model does not require ground truth labels for each channel, only global flag is used. This effectively distinguishes the model from classical classification methods. Being applied to CMS data collected in the year 2010, this approach proves its ability to decompose anomaly by separate channels.Comment: Presented at ACAT 2017 conference, Seattle, US

Two States in the Holy Land?: International Recognition and the Israeli-Palestinian Conflict

How do states decide to extend or withhold international recognition in cases of contested sovereignty? We focus on how religion shapes the incentives of states in making this decision, both at the domestic level through religious institutions and at the international level through religious affinities. States with transnational religious ties to the contested territory are more likely to extend recognition. At the domestic level, states that heavily regulate religion are less likely to extend international recognition. We test these conjectures, and examine others in the literature, with two new data sets on the international recognition of both Palestine and Israel and voting on the United Nations resolution to admit Palestine as a non-member state observer, combined with global data on religious regulation and religious affinities. In cases of contested sovereignty, the results provide support for these two mechanisms through which religion shapes foreign policy decisions about international recognition