Non Oblivious Watermarking Technique for JPEG2000 Compressed Images Using Arnold Scrambling of Unequal Size Watermark Blocks

In this paper, a watermarking technique for JPEG2000 compressed image is proposed. Scrambling of secret message is performed block-wise using Arnold Transform. Secret message is divided into non-overlapping blocks of unequal size and then Arnold transform is applied on each block and secret key is generated based on the periodicity of each block. Scrambled secret message is embedded into qualified significant wavelet coefficients of a cover image. After embedding the secret message into wavelet coefficients, the remaining processes of JPEG2000 standard are executed to compress the watermarked image at different compression rates. Scaling Factor (SF) is used to embed watermark into wavelet coefficients and the value of SF is stored into COM box of the code stream of JPEG2000 compressed image and this SF value and secret key are used to extract the embedded watermark on the receiver side. The performance of the proposed technique is robust to a variety of attacks like image cropping, salt and pepper noise, and rotation. Proposed technique is compared with the existing watermarking techniques for JPEG2000 compressed images to show its effectiveness

Ashgourd Cultivation: a Success Story

Kandi area of Punjab constitutes the 10 per cent of the total state area. The area is characterized by the erratic distribution of rainfall, small and scattered land holdings and severe soil erosion on sloppy lands, poor soil fertility and low moisture retention capacity. Maize is the main kharif season crop in kandi area and covers about 70 per cent of the total cropped area. The yield potential of the maize crop is very low which might be due to uncertainly of rains and lack of resources (good quality seed, implements etc.). Nowadays, increase in wild and stray animals’ nuisance in the area has led to major setback for the cultivation of maize crop in the area. Crop failures have become a common problem in the area and famers start keeping some of their land barren.Not AvailableNot Availabl

Four Decades of Dryland Agricultural Research in Kandi Area of Punjab

Not AvailableDuring seventies and eighties, dryland experiments were conducted on farmers’ fields in the villages of Nawangram, Kotmajra and Jhonewal located within a distance of 10-15 km from Garhshankar in Hoshiarpur district of Punjab. The village Nawangram represented gently sloping and undulating lands in Kandi area which lies at the foot of the lower Shiwaliks. The latter two villages represented relatively levelled lands in the Beet area where soils are heavy and water retentive. During late eighties, dryland experiments were also carried out at Balachaur on the farmers’ fields. In the year 1992, the dryland project was shifted at the Zonal Research Station for Kandi Area, Ballowal Saunkhri.Not Availabl

Noise levels at traffic intersections and awareness of noise pollution among traffic policemen and automobile drivers

Introduction: Noise pollution is an important health hazard in modern times and traffic policemen and automobile drivers are exposed to unregulated vehicular noise. This study aims to estimate the exposure levels from traffic noise for traffic policemen and automobile drivers and assess their awareness regarding noise pollution and the use of noise prevention measures. Methods: An analytical cross-sectional study was carried out comprising the exposed and the control group with 121 people in each group. Sound level estimation was carried out across 20 traffic intersections in the city at various times to assess the noise levels. All the participants were administered a pretested questionnaire to assess their awareness regarding noise pollution and as well as the use of noise prevention strategies.  The chi-square test was used to estimate the difference between the two groups. P <0.05 was considered statistically significant. Results: The noise levels at traffic intersections are above the permitted and acceptable limits. The mean ±SD of sound levels at traffic points range from 76.7±5.8 dB to 83.4±6.3 dB across various traffic intersections. The mean noise level at the traffic intersection was in the high-risk category (81-86dB) in 25% of traffic points while 75% of traffic points had noise levels in the moderate risk (76 - 81dB) category. 88% of the exposed group and 95% of the control group considered noise to be a form of pollution even though they were not aware of all the harmful effects. In practice, only 34% of study participants used some form of hearing protection measures, even though the majority were aware of the need to do so. Conclusion: The noise levels at traffic intersections are high. This is coupled with a lack of adequate use of hearing protective devices which can be detrimental to the inner ear. Frequent awareness programs are necessary to educate the occupationally exposed personnel on proper noise prevention strategies. At the same, time it is necessary to take decisive measures to curb the ever-increasing menace of occupational noise exposure

Enhancing biopharmaceutical performance of an anticancer drug by long chain PUFA based self-nanoemulsifying lipidic nanomicellar system.

The aim of this study was to develop polyunsaturated fatty acid (PUFA) long chain glyceride (LCG) enriched self-nanoemulsifying lipidic nanomicelles systems (SNELS) for augmenting lymphatic uptake and enhancing oral bioavailability of docetaxel and compare its biopharmaceutical performance with a medium-chain fatty acid glyceride (MCG) SNELS. Equilibrium solubility and pseudo ternary phase studies facilitated the selection of suitable LCG and MCG. The critical material attributes (CMAs) and critical process parameters (CPPs) were earmarked using Placket-Burman Design (PBD) and Fractional Factorial Design (FFD) for LCG- and MCG-SNELS respectively, and nano micelles were subsequently optimized using I- and D-optimal designs. Desirability function unearthed the optimized SNELS with Temul 85% and Perm45min >75%. The SNELS demonstrated efficient biocompatibility and energy dependent cellular uptake, reduced P-gp efflux and increased permeability using bi-directional Caco-2 model. Optimal PUFA enriched LCG-SNELS exhibited distinctly superior permeability and absorption parameters during ex vivo permeation, in situ single pass intestinal perfusion, lymphatic uptake and in vivo pharmacokinetic studies over MCG-SNELS. [Abstract copyright: Copyright © 2017. Published by Elsevier B.V.

Curcumin And Etoricoxib Encapsulated Liposomes: Formulation, Characterization And Anti-Inflammatory Effects In Rat Models

To enhance anti-inflammatory efficacy of Curcumin (CURC) and Etoricoxib (ETRX); and to reduce their notorious side effects, they were loaded into liposomal formulations (LFs). The present study aimed at formulation, characterization and evaluation of anti-inflammatory effects of LFs of CURC in combination with ETRX in experimental acute inflammation (AI) in rat model induced by carrageenan administration. The existing pharmaceuticals for treating arthritis are analgesics, steroids and non-steroidal anti-inflammatory drugs (NSAIDs), which reduce the symptoms such as severe pain and inflammation. Classical NSAIDs are cyclooxygenase (COX) inhibitors that inhibit prostaglandins (PGs) and thromboxane synthesis, thereby reducing inflammation. New NSAIDs selectively inhibit COX-2 and are usually specific to inflamed tissue, which decreases the risk of peptic ulcer. However, their long-term use cannot be sustained due to inadequate pain relief, immune disturbances and serious gastrointestinal and cardiovascular adverse events. Therefore, plant-based product like CURC with anti-inflammatory properties and minimum side effects are needed for the treatment of arthritis, including rheumatoid arthritis (RA) and osteoarthritis, especially after the withdrawal of many Food and Drug Administration (FDA)-approved anti- inflammatory drugs. However, its poor solubility, low chemical stability and short half-life following systemic absorption contribute to CURC being considered a pharmaceutical challenge. Numerous delivery systems have been proposed as means to tailor its biological properties. In this research, we are particularly interested in potential of CURC as an anti-inflammatory agent in combination with ETRX and delivery in the form of LFs. ETRX; a NSAID is proposed to treat inflammation in rat model as it is known for its anti-inflammatory, analgesic and antipyretic effects. ETRX, a widely prescribed anti- inflammatory drug belongs to class IΙ under BCS (biopharmaceutical classification system) and exhibit variable oral bioavailability due to its poor aqueous solubility. This research is aimed to study synergistic effect of a natural compound CURC and an allopathic NSAID moiety ETRX to treat inflammation in rat model, by oral ingestion in the form of LF as an efficient drug delivery system. Hence, we propose LF as a mean to overcome the CURC limitations. Liposomes (LPs) encapsulation of CURC makes this formulation amenable to circumvent the problem of poor oral availability that limits the utility of free CURC. The LFs can potentiate the effects of encapsulated drugs by sustaining the release over an extended period of time. The results of our study demonstrated that the association of CURC with ETRX in the form of LFs could potentiate the anti-inflammatory effects in reduced doses in vitro and in rat model. The LFs were spherical in shape in TEM images at various resolutions. The particle size of optimized CURC-ETRX LPs was found to be 276.1 nm with PDI value of 24.5. The maximum EE for CURC and ETRX in optimized formulation (F2) was found 98.915% and 93.877% respectively. The % EE of CURC-ETRX loaded LFs was found to be dependent on the lipid concentration, resulting almost quantitatively for a maximum 15 mg of total lipids (PC+CL) and progressively decreasing at higher 20 mg of total lipid (PC+CL) content, may be due to precipitation of drugs at higher lipid concentrations. The cumulative percentage release of CURC and ETRX from optimized formulations was found to be 59.64% and 83.11% respectively, for a period of 24 hours. We investigated the in vivo effect of CURC and ETRX loaded LF on local edema in carrageenan-induced paw edema in rat model. The percentage inhibition of edema in rat model was found to be better for CURC-ETRX LF in comparison to conventional CURC and ETRX in solution forms (p&lt;0.05). Hence, the association of CURC and ETRX to a low dose in the form of LFs could be an appropriate combination to decrease NSAID doses used to reduce pain, inflammatory cytokines, and histological changes in AI

Interventions to improve linkage along the HIV-tuberculosis care cascades in low- and middle-income countries: A systematic review and meta-analysis.

INTRODUCTION: In support of global targets to end HIV/AIDS and tuberculosis (TB) by 2030, we reviewed interventions aiming to improve TB case-detection and anti-TB treatment among people living with HIV (PLHIV) and HIV testing and antiretroviral treatment initiation among people with TB disease in low- and middle-income countries (LMICs). METHODS: We conducted a systematic review of comparative (quasi-)experimental interventional studies published in Medline or EMBASE between January 2003-July 2021. We performed random-effects effect meta-analyses (DerSimonian and Laird method) for interventions that were homogenous (based on intervention descriptions); for others we narratively synthesized the intervention effect. Studies were assessed using ROBINS-I, Cochrane Risk-of-Bias, and GRADE. (PROSPERO #CRD42018109629). RESULTS: Of 21,516 retrieved studies, 23 were included, contributing 53 arms and 84,884 participants from 4 continents. Five interventions were analyzed: co-location of test and/or treatment services; patient education and counselling; dedicated personnel; peer support; and financial support. A majority were implemented in primary health facilities (n = 22) and reported on HIV outcomes in people with TB (n = 18). Service co-location had the most consistent positive effect on HIV testing and treatment initiation among people with TB, and TB case-detection among PLHIV. Other interventions were heterogenous, implemented concurrent with standard-of-care strategies and/or diverse facility-level improvements, and produced mixed effects. Operational system, human resource, and/or laboratory strengthening were common within successful interventions. Most studies had a moderate to serious risk of bias. CONCLUSIONS: This review provides operational clarity on intervention models that can support early linkages between the TB and HIV care cascades. The findings have supported the World Health Organization 2020 HIV Service Delivery Guidelines update. Further research is needed to evaluate the distinct effect of education and counselling, financial support, and dedicated personnel interventions, and to explore the role of community-based, virtual, and differentiated service delivery models in addressing TB-HIV co-morbidity

Study of Stress and Deformation by Mono Composite Leaf Spring

The purpose of this project work is to estimate the deflection and stress on the basis of Load changes as well as Young’s Modulus in Mono Composite Leaf Spring by computer analysis. The emphasis in this project is given on the effect of Young’s Modulus on deflection and stress produced in Leaf Spring and all the process will be done by  the application of computer aided analysis using finite element concept. The component chosen for analysis is a leaf spring which is an automotive component used to absorb vibrations. Under operating conditions, the behavior of the leaf spring is complicated due to its clamping effects and interleaf contact; hence its analysis is necessary to pre-predict the displacement, and stresses. Although many projects have been made earlier regarding the concept of stress and deflection on leaf spring on the basis of load, but the new thing on these project is the estimation of leaf spring on the basis of Young’s Modulus which makes these project unique because such project has not been made yet. Another thing that makes it differ is the use of CATIA software not only for modeling the Leaf Spring but also for the whole analysis. So all the process and analysis is based on the results obtained in CATIA software under given specified conditions