Mefenamic acid and diclofenac in the treatment of menorrhagia and dysmenorrhea in dysfunctional uterine bleeding: a randomized comparative study

Background: There is a perception that Mefenamic Acid should be the preferred NSAID for menorrhagia. However, there are insufficient evidences to prove this. Further RCTs are required to compare individual NSAIDs.Purposes of the study were to assess and compare the efficacy of mefenamic acid and diclofenac in control of menorrhagia in patients with DUB, to assess and compare their analgesic effects in dysmenorrhea associated with DUB and to study their adverse effects.Methods: Sixty-eight patients were randomized into either Mefenamic Acid (n=34) or Diclofenac (n=34) group. Efficacy variables (Pictorial Blood loss Assessment Chart quantification, Number of pads used, Number of days of menstrual bleeding, Visual Analog Scale score) and adverse effects were recorded over three menstrual cycles.Results: The median reduction of menorrhagia with Mefenamic Acid was 43.39% (Range: 2.86% to 94.4%) and for Diclofenac was 57.5% (Range: 9.9% to 93.58%). The Diclofenac group showed a statistically significant decrease in median bleeding volume, median number of pads used and median number of days of bleeding compared to the Mefenamic Acid group (p<0.05, CI = 95%) but did not show a statistically significant decrease in median VAS score compared to the Mefenamic Acid group. Adverse effects with both groups were mild.Conclusions: Mefenamic Acid and Diclofenac individually managed to significantly reduce excessive bleeding compared to baseline. Diclofenac fared better than Mefenamic Acid in terms of control of excessive menstrual bleeding. Both these agents were able to reduce the menstrual pain and on comparison, were found to be equi-efficacious

RescueAlert-an accident detection and rescue mechanism

With the increase of vehicles and cars of different kind and the large movement that occurs every day on the roads it was natural to observe an increase in traffic accidents, but the real dilemma lies in how to make the rescue process efficient. The problem that we want to solve is the response of ambulances towards accidents and the lengthy registration process of patients in hospitals. In the above two scenarios, the manual process of calling the ambulance leads to delay in rescue of patients from an accident and the delay in registration of patient leads to delay in medication or treatment of the patient. We want to make the process more efficient by automating accident detection for increasing the efficiency of the ambulance rescue process and by sending the details of the patient before the patient reaches the hospitals for faster treatment of patients. Along with this, alert messages will be sent to the family or friends of the patients to notify them as soon as an accident is detected

Thermalization and hydrodynamics in an interacting integrable system: the case of hard rods

We consider the relaxation of an initial non-equilibrium state in a one-dimensional fluid of hard rods. Since it is an interacting integrable system, we expect it to reach the Generalized Gibbs Ensemble (GGE) at long times for generic initial conditions. Here we show that there exist initial conditions for which the system does not reach GGE even at very long times and in the thermodynamic limit. In particular, we consider an initial condition of uniformly distributed hard-rods in a box with the left half having particles with a singular velocity distribution (all moving with unit velocity) and the right half particles in thermal equilibrium. We find that the density profile for the singular component does not spread to the full extent of the box and keeps moving with a fixed effective speed at long times. We show that such density profiles can be well described by the solution of the Euler equations almost everywhere except at the location of the shocks, where we observe slight discrepancies due to dissipation arising from the initial fluctuations of the thermal background. To demonstrate this effect of dissipation analytically, we consider a second initial condition with a single particle at the origin with unit velocity in a thermal background. We find that the probability distribution of the position of the unit velocity quasi-particle has diffusive spreading which can be understood from the solution of the Navier-Stokes equation of the hard rods. Finally, we consider an initial condition with a spread in velocity distribution for which we show convergence to GGE. Our conclusions are based on molecular dynamics simulations supported by analytical arguments

BCS Class II Drug & Its Solubility Enhancement: A Review

The objective of this review article is to summarize literature data pertinent to potential excipient effects on intestinal drug permeability and transit. Despite the use of excipients in drug products for decades, considerable research efforts have been directed towards evaluating their potential effects on drug bioavailability. Potential excipient concerns stem from drug formulation changes (e.g., scale-up and post-approval changes, development of a new generic product). Regulatory agencies have established&nbsp;in vivo&nbsp;bioequivalence standards and, as a result, may waive the&nbsp;in vivo&nbsp;requirement, known as a biowaiver, for some oral products. Biowaiver acceptance criteria are based on the&nbsp;in vitro&nbsp;characterization of the drug substance and drug product using the Biopharmaceutics Classification System (BCS). Various regulatory guidance documents have been issued regarding BCS-based biowaivers, such that the current FDA guidance is more restrictive than prior guidance, specifically about excipient risk. In particular, sugar alcohols have been identified as potential absorption-modifying excipients. These biowaivers and excipient risks are discussed here

Post-COVID-19 Disease Associated with Mucormycosis and Guillain-Barré Syndrome: A Causal Association or Just a Coincidence?

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Originating from Wuhan, China, COVID-19 has rapidly spread worldwide. COVID-19 is primarily considered to be a respiratory illness, but with time there is enough evidence about the extrapulmonary manifestations of the disease. One of the neurological manifestations is Guillain-Barré syndrome (GBS). It may be associated with mucormycosis, with majority of cases occurring in India. Here, we report a case of a 40-year-old male patient, a known case of hypertension and diabetes mellitus who presented with the complaints of fever, cough and shortness of breath since May 10, 2021. He was found to be RT-PCR positive for COVID-19 on May 12, 2021. While recovering from COVID-19, on May 25, he was suspected to have rhino-orbital mucormycosis, which was confirmed on tissue specimen. While recovering from rhino-orbital mucormycosis, on July 26, the patient complained of weakness in bilateral lower limbs, followed by weakness in both upper limbs after 2 days. GBS was confirmed on nerve conduction study (NCS) and cerebrospinal fluid (CSF) examination. Patient was treated with intravenous immunoglobulin (IVIG), and while on treatment, the patient showed no significant improvement. Invasive ventilation was started in view of respiratory muscle involvement. The patient also developed autonomic dysfunction. He went into cardiac arrest and despite best efforts, couldn’t be revived. Currently, to the best of our knowledge, there is no data to tell that both mucormycosis and GBS can occur in association with COVID-19. This case aims to raise awareness among the healthcare providers for this type of association. COVID-19 may be a cause or it may just be a mere coincidence, needs further stud

Chiral anomalies induced transport in Weyl semimetals in quantizing magnetic field

Weyl semimetals host relativistic chiral quasiparticles, which display quantum anomalies in the presence of external electromagnetic fields. Here, we study the manifestations of chiral anomalies in the longitudinal and planar magneto-transport coefficients of Weyl semimetals, in the presence of a quantizing magnetic field. We present a general framework for calculating all the transport coefficients in the regime where multiple Landau levels are occupied. We explicitly show that all the longitudinal and planar transport coefficients show Shubnikov-de Haas like quantum oscillations which are periodic in 1/B. Our calculations recover the quadratic-B dependence in the semiclassical regime, and predict a linear-B dependence in the ultra-quantum limit for all the transport coefficients.Comment: 11 pages, 8 figures, Comments are welcom

Compact Planar One-Shot Circular Spark Gap Switch

The fabrication and characterisation of micro spark gap switch for single shot firing applications are given in detailed . A circular switch with triggering electrode is realised on alumina substrate and can be integratable easily with the electronics for ignition applications. Circular switch is realised on 25 mil alumina substrate within substrate diameter of 10 mm. The switch measurement shows having repeatable performance of pulse peak current of around 2000 A and less than 100 ns rise time. This article details the design, development including fabrication aspects of spark switch with trigger capabilities along with characterisation of switch on alumina substrates.

Design and Simulation a Solar Golf Cart for use in St. John’s, Newfoundland

This paper introduces a solar-powered two-seater golf cart designed for St. John's, Newfoundland. We model it using HOMER PRO and MATLAB/Simulink, considering the PV generation, BLDC motor operation, battery dynamics, MPPT, and speed control. The economic analysis assesses component cost-effectiveness. Power surge protection and control design are also discussed. Additionally, the study extends practically to the Bally Haly Country Club's 18-hole golf course, featuring a Morphorn BLDC motor (1800W), Sharp 250W solar panel, and Discover 24V 110Ah battery system with 1 panel and 3 batteries, demonstrating the system design and simulation