The Indore population's morphometric study of the nutrient foramina of the dried radius

Background: Bone formation, growth and its vitality necessitates blood supply. Nutrient artery is the key source of blood supply to the long bone apart from the other important sources like periosteal, metaphyseal and epiphyseal arteries. Nutrient foramina allow nutrient artery. Typically, the direction of the nutrient foramina is towards the elbow joint in radius, away from its growing end. Knowledge of foramen index, number, direction and size of the nutrient foramina assists the surgeon to take and exact section of bone in case of bone resection and transplantation techniques. The aim of the present study is to determine the number, position, size direction of the nutrient foramina and the Foramen Index of the human dry radius bones. Methods: In the present study, 100 radius bones of unknown age and sex were taken into consideration from the department of anatomy Index Medical College, Indore (MP), India. Results: Most of the foramen was observed on the anterior surface of the bone. Nutrient foramina was found to be absent in 4 right sided and 3 left sided bones. The foramen index on right side was 34.92±4.97 cm whereas on the left side 34.79±4.43 cm. The nutrient foramen was directed towards the proximal end of radius in all the bones studied. Conclusions: In the present study the average length of the bone and foramina of the size larger are more on the right side when compared to the left side. The foramina are located mostly in the middle third of the bone of the anterior surface. This study may add to the present statistical data available on foramen index number of foramen and their location in the population of Indore region, during recent orthopaedic techniques like bone resection and transplantation

Compact Planar One-Shot Circular Spark Gap Switch

The fabrication and characterisation of micro spark gap switch for single shot firing applications are given in detailed . A circular switch with triggering electrode is realised on alumina substrate and can be integratable easily with the electronics for ignition applications. Circular switch is realised on 25 mil alumina substrate within substrate diameter of 10 mm. The switch measurement shows having repeatable performance of pulse peak current of around 2000 A and less than 100 ns rise time. This article details the design, development including fabrication aspects of spark switch with trigger capabilities along with characterisation of switch on alumina substrates.

Drug utilization study and prescribing patterns in psychiatry patients at a tertiary care hospital

Background: The Drug utilization research (DUR) compares drug use between different countries and regions and is used to assess the rationality of prescribing pattern of the drug therapy. With this background we decided to evaluate antipsychotic drugs prescribing pattern in the psychiatric patients in a tertiary care hospital.Methods: The study was carried out at Department of Psychiatry, DSMCH. It was open label, cross - sectional, prescribed Documents based study. Duration of the study was one month (May-2017). Out-Patient number, age, sex, diagnosis, prescribed generic name, brand name, dose, route of administration, duration of therapy obtained from the Prescription register of Out - Patient Department of the Psychiatry.Results: The clinical experiences of the Psychiatrist I, II and III were 17 years, 35 years and 10 years respectively. The Psychiatrist I, II and III prescribed treatment for 36 (31.9%), 61 (54%) and 16 (14.2%) patients respectively. Among overall (n=113) patients (average age 38.9 years), male n=56 (49.6%) and female=57 (50.4%) were treated by all the three psychiatrists. The percentage of prescription of various drugs used were: Escitalopram (15.7%), Clonazepam (14.6%), Sertraline (8.7%), Risperidone (7.5%), Propranolol (6.7%), Olanzapine (6.3%), Quetiapine (5.9%), Trihexyphenidyl (5.5%), Amitriptyline (5.1%) and Other prescribed drugs, were between (0.4 to 2.8%).Conclusions: From this study, it can conclude that rational usage of drugs were followed in this study. All three prescribers (Psychiatrist I, II, and III) prescriptions were found to be rationale

Clobetasol propionate cream 0.025%: a topical therapeutic for dermatological disorders

Due to the anti-inflammatory and vasodilator effects of topical corticosteroids, they help in treating atopic eczema, psoriasis, chronic hand eczema, and localized vitiligo, among other dermatological diseases. Clobetasol propionate (CP) is the most popular topical medication used to treat plaque psoriasis. It has anti-inflammatory, antimitotic, antipruritic, and immunosuppressive characteristics. The USFDA has approved CP 0.025% cream for the treatment of moderate-to-severe psoriasis in adults. Propylene glycol, short-chain alcohols, and sorbitol-based emulsifiers are all recognized contact allergens, and the formulation has exhibited hypoallergenic effects. CP 0.025% is an effective and safe agent due to its high active ingredient penetration and minimal systemic absorption. The clinical experience of employing CP 0.025% cream in diverse dermatologic disorders is discussed in this case series, with a focus on its efficacy and safety

Genotype x environment interaction and stability of indigenous coriander (Coriandrum sativum L.) genotypes for seed yield in different agro-climatic zones of Chhattisgarh

The present study was conducted to find out the stability and yield performances of 13 genotypes of indigenous coriander (Coriandrum sativum L.) evaluated in different agro climatic zones of Chhattisgarh. The trials were laid out in a Randomized Block Design (RBD) with three replications at three locations for three years resulting in nine environments (Genotype × year interactions). The genotypes and G × E interactions revealed significant differences at p <0.01 for seed yield indicating varieties and testing environments were distinct from each other. Additive main effects and multiplicative interaction analysis (AMMI-biplot) indicated that the yield performances of indigenous coriander genotypes were highly affected by the environments. The first two principal component axes (PCA 1 and PCA 2) were significant and they explained 67% of the total genotype x environment interaction of which 42.4% and 24.6% were represented by PCA 1 and PCA 2, respectively. A biplot generated using genotypic and environmental scores of the first two AMMI components demonstrated that genotype with larger PCA 1 and lower PCA 2 scores were high yielding and stable genotypes and genotypes with lower PCA 1 and larger PCA 2 scores were low yielding and unstable cultivars in tested locations. The genotype GC 5 C-101 (ICS 4) showed higher grain yields (16.35 q ha-1) over grand mean (13.03 q ha-1) and also had the minimum PCA 1 score, minimum AMMI stability value (ASV) and yield stability index (YSI). Therefore genotype ICS 4 (Chhattisgarh Shri Chandrahasini Dhaniya -2) showed wider stability across different agro climatic environments of Chhattisgarh

Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one

In our study, a series of novel 3-(4-(benzylideneamino) phenylimino) 4-fluoroindolin-2-one derivatives were synthesized and characterized by spectral (I.R, 1H NMR, mass) and elemental analysis. The title compounds (N1-N10) were evaluated for analgesic, anti-inflammatory, and ulcerogenic index activities. Results displayed that compound N3 exhibited significant analgesic activity. Among the title compounds studied, N2, N3, and N8 exhibited significant anti- inflammatory activity comparable to reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin

Applications of raman spectroscopy in dentistry part II: Soft tissue analysis

Raman spectroscopy is rapidly moving from an experimental technique for the analysis of biological molecules to a tool for the real-time clinical diagnosis and in situ evaluation of the oral tissue in medical and dental research. The purpose of this study is to identify various applications of Raman spectroscopy, to evaluate the contemporary status and to explore future directions in the field of dentistry. Several in-depth applications are presented to illustrate Raman spectroscopy in early diagnosis of soft tissue abnormalities. Raman spectroscopy allows to analyze histological and biochemical composition of biological tissues. The technique not only demonstrates its role in the disclosure of dysplasia and malignancy but also in performing guided biopsies, diagnosing sialoliths, and assessment of surgical margins. Raman spectroscopy is used to identify the molecular structures and its components to give substantial information about the chemical structure properties of these molecules. In this paper, we acquaint the utilization of Raman spectroscopy in analyzing the soft tissues in relation to dentistry

AN5D: Automated Stencil Framework for High-Degree Temporal Blocking on GPUs

Stencil computation is one of the most widely-used compute patterns in high performance computing applications. Spatial and temporal blocking have been proposed to overcome the memory-bound nature of this type of computation by moving memory pressure from external memory to on-chip memory on GPUs. However, correctly implementing those optimizations while considering the complexity of the architecture and memory hierarchy of GPUs to achieve high performance is difficult. We propose AN5D, an automated stencil framework which is capable of automatically transforming and optimizing stencil patterns in a given C source code, and generating corresponding CUDA code. Parameter tuning in our framework is guided by our performance model. Our novel optimization strategy reduces shared memory and register pressure in comparison to existing implementations, allowing performance scaling up to a temporal blocking degree of 10. We achieve the highest performance reported so far for all evaluated stencil benchmarks on the state-of-the-art Tesla V100 GPU